Duplicated chromosomal fragments stabilize shortened telomeres in normal human IMR-90 cells before transition to senescence. (Q39512099)

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6 February 2020

title

Duplicated chromosomal fragments stabilize shortened telomeres in normal human IMR-90 cells before transition to senescence (English)

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6 February 2020

7

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6 February 2020

Laure Sabatier

6

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6 February 2020

author name string

Sebastian Zahnreich

1

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6 February 2020

Damir Krunic

2

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6 February 2020

Larissa Melnikova

3

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6 February 2020

Agnes Szejka

4

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6 February 2020

Barbara Drossel

5

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Sylvia Ritter

8

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Claudia Fournier

9

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publication date

1 May 2012

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Journal of Cellular Physiology

6 February 2020

published in

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volume

227

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issue

5

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page(s)

1932-1940

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Evidence for a critical telomere length in senescent human fibroblasts

6 February 2020

cites work

1 reference

N-t-butyl hydroxylamine, a hydrolysis product of alpha-phenyl-N-t-butyl nitrone, is more potent in delaying senescence in human lung fibroblasts

21 January 2018

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Telomeres, chromosome instability and cancer

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Human skin fibroblasts in vitro differentiate along a terminal cell lineage

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Telomeres and telomerase: their mechanisms of action and the effects of altering their functions

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Telomere dynamics during replicative senescence are not directly modulated by conditions of oxidative stress in IMR90 fibroblast cells

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Analyzing radiation-induced complex chromosome rearrangements by combinatorial painting

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Telomere dynamics, end-to-end fusions and telomerase activation during the human fibroblast immortalization process

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Tissue context-activated telomerase in human epidermis correlates with little age-dependent telomere loss.

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DNA amplification by breakage/fusion/bridge cycles initiated by spontaneous telomere loss in a human cancer cell line.

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Contribution of telomerase RNA retrotranscription to DNA double-strand break repair during mammalian genome evolution

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Differential degradation of intracellular proteins in human skin fibroblasts of mitotic and mitomycin-C (MMC)-induced postmitotic differentiation states in vitro.

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The loss of a single telomere can result in instability of multiple chromosomes in a human tumor cell line

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New concepts to improve resolution and sensitivity of molecular cytogenetic diagnostics by multicolor fluorescence in situ hybridization

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Defining cellular senescence in IMR-90 cells: a flow cytometric analysis

21 January 2018

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21 January 2018

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Extended lifespan and immortalization of human fibroblasts induced by X-ray irradiation

21 January 2018

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From telomere loss to p53 induction and activation of a DNA-damage pathway at senescence: the telomere loss/DNA damage model of cell aging

21 January 2018

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Molecular signaling and genetic pathways of senescence: Its role in tumorigenesis and aging

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