EZH2 supports nasopharyngeal carcinoma cell aggressiveness by forming a co-repressor complex with HDAC1/HDAC2 and Snail to inhibit E-cadherin. (Q39521859)

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scientific article published on 20 June 2011

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English	EZH2 supports nasopharyngeal carcinoma cell aggressiveness by forming a co-repressor complex with HDAC1/HDAC2 and Snail to inhibit E-cadherin.	scientific article published on 20 June 2011

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EZH2 supports nasopharyngeal carcinoma cell aggressiveness by forming a co-repressor complex with HDAC1/HDAC2 and Snail to inhibit E-cadherin (English)

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Z-T Tong

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M-Y Cai

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X-G Wang

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L-L Kong

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S-J Mai

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Y-H Liu

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H-B Zhang

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Y-J Liao

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F Zheng

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T-H Liu

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X-W Bian

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M C Lin

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M-S Zeng

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Y-X Zeng

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H-F Kung

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D Xie

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20 June 2011

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583-594

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https://scigraph.springernature.com/pub.10.1038/onc.2011.254

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EZH2 expression is associated with high proliferation rate and aggressive tumor subgroups in cutaneous melanoma and cancers of the endometrium, prostate, and breast

1 reference

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The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells

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Polycomb complexes repress developmental regulators in murine embryonic stem cells

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EZH2 protein: a promising immunomarker for the detection of hepatocellular carcinomas in liver needle biopsies

1 reference

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The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression

1 reference

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Repression of E-cadherin by the polycomb group protein EZH2 in cancer

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Role of histone H3 lysine 27 methylation in Polycomb-group silencing

1 reference

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The Polycomb Ezh2 methyltransferase regulates muscle gene expression and skeletal muscle differentiation

1 reference

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Lentivirus-mediated RNA interference targeting enhancer of zeste homolog 2 inhibits hepatocellular carcinoma growth through down-regulation of stathmin.

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Expression of enhancer of zeste homologue 2 is significantly associated with increased tumor cell proliferation and is a marker of aggressive breast cancer

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Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors

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Enhancer of zeste homolog 2 downregulates E-cadherin by mediating histone H3 methylation in gastric cancer cells

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https://api.crossref.org/works/10.1038%2FONC.2011.254

21 January 2018

Polycomb complex 2 is required for E-cadherin repression by the Snail1 transcription factor.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.254

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High expression of EZH2 is associated with tumor proliferation and prognosis in human oral squamous cell carcinomas

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.254

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Control of developmental regulators by Polycomb in human embryonic stem cells

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https://api.crossref.org/works/10.1038%2FONC.2011.254

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Focus on nasopharyngeal carcinoma

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21 January 2018

Expression of the enhancer of zeste homolog 2 is correlated with poor prognosis in human gastric cancer.

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Polycomb response elements and targeting of Polycomb group proteins in Drosophila.

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Snail mediates E-cadherin repression by the recruitment of the Sin3A/histone deacetylase 1 (HDAC1)/HDAC2 complex

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https://api.crossref.org/works/10.1038%2FONC.2011.254

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Increased expression of the polycomb group gene, EZH2, in transitional cell carcinoma of the bladder

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EZH2 supports ovarian carcinoma cell invasion and/or metastasis via regulation of TGF-beta1 and is a predictor of outcome in ovarian carcinoma patients.

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The polycomb group protein EED interacts with YY1, and both proteins induce neural tissue in Xenopus embryos

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Genome-wide analysis of Polycomb targets in Drosophila melanogaster

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Polycomb silencing mechanisms and the management of genomic programmes

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Roles of the EZH2 histone methyltransferase in cancer epigenetics

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The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.254

21 January 2018

Clinicopathological significance of EZH2 mRNA expression in patients with hepatocellular carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.254

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PcG proteins, DNA methylation, and gene repression by chromatin looping.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.254

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Transcriptional repression mediated by the human polycomb-group protein EED involves histone deacetylation

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.254

21 January 2018

The polycomb group protein EZH2 is involved in progression of prostate cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.254

21 January 2018

E-cadherin regulates metastasis of pancreatic cancer in vivo and is suppressed by a SNAIL/HDAC1/HDAC2 repressor complex

1 reference

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21 January 2018

Hierarchical recruitment of polycomb group silencing complexes

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The management of neck metastases in nasopharyngeal cancer.

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21 January 2018

High expression of EZH2 is associated with tumor aggressiveness and poor prognosis in patients with esophageal squamous cell carcinoma treated with definitive chemoradiotherapy

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.254

21 January 2018

Heterogeneous expression and association of ?-catenin, p16 and c-myc in multistage colorectal tumorigenesis and progression detected by tissue microarray

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X-tile: a new bio-informatics tool for biomarker assessment and outcome-based cut-point optimization

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Clinical significance of enhancer of zeste homolog 2 expression in colorectal cancer cases

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Mechanisms of polycomb gene silencing: knowns and unknowns

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