Differential roles of Smad2 and Smad3 in the regulation of TGF-β1-mediated growth inhibition and cell migration in pancreatic ductal adenocarcinoma cells: control by Rac1. (Q39533795)

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scientific article published on 30 May 2011

Language	Label	Description	Also known as
English	Differential roles of Smad2 and Smad3 in the regulation of TGF-β1-mediated growth inhibition and cell migration in pancreatic ductal adenocarcinoma cells: control by Rac1.	scientific article published on 30 May 2011

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scholarly article

1 reference

Europe PubMed Central

12 September 2017

Differential roles of Smad2 and Smad3 in the regulation of TGF-β1-mediated growth inhibition and cell migration in pancreatic ductal adenocarcinoma cells: control by Rac1. (English)

1 reference

Europe PubMed Central

12 September 2017

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based on heuristic

inferred from title

invasive ductal carcinoma

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based on heuristic

inferred from title

pancreatic ductal adenocarcinoma

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based on heuristic

inferred from title

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based on heuristic

inferred from title

pancreatic ductal carcinoma

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based on heuristic

inferred from title

object named as

Frank Gieseler

5

1 reference

ORCID Public Data File 2021

author name string

Hendrik Ungefroren

1

1 reference

Europe PubMed Central

12 September 2017

Stephanie Groth

2

1 reference

Europe PubMed Central

12 September 2017

Susanne Sebens

3

1 reference

Europe PubMed Central

12 September 2017

Hendrik Lehnert

4

1 reference

Europe PubMed Central

12 September 2017

Fred Fändrich

6

1 reference

Europe PubMed Central

12 September 2017

language of work or name

1 reference

based on heuristic

inferred from title

publication date

30 May 2011

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Europe PubMed Central

12 September 2017

Molecular Cancer

1 reference

Europe PubMed Central

12 September 2017

10

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Europe PubMed Central

12 September 2017

67

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Europe PubMed Central

12 September 2017

describes a project that uses

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RTCA

1 reference

CZ Software Mentions: A large dataset of software mentions in the biomedical literature

https://scigraph.springernature.com/pub.10.1186/1476-4598-10-67

0 references

Rac and Rho GTPases in cancer cell motility control

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13 September 2017

Localized and reversible TGFbeta signalling switches breast cancer cells from cohesive to single cell motility

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13 September 2017

Rac1 GTPase: a "Rac" of all trades.

1 reference

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13 September 2017

Phospho-control of TGF-beta superfamily signaling

1 reference

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13 September 2017

Reversible Smad-dependent signaling between tumor suppression and oncogenesis

1 reference

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13 September 2017

A tale of two proteins: differential roles and regulation of Smad2 and Smad3 in TGF-beta signaling

1 reference

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13 September 2017

Aggressive pancreatic ductal adenocarcinoma in mice caused by pancreas-specific blockade of transforming growth factor-beta signaling in cooperation with active Kras expression

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Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer

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The logic of TGFbeta signaling.

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13 September 2017

The endogenous ratio of Smad2 and Smad3 influences the cytostatic function of Smad3.

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Roles of the Rac1 and Rac3 GTPases in human tumor cell invasion

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Ectopic expression of VAV1 reveals an unexpected role in pancreatic cancer tumorigenesis

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13 September 2017

Smad4-independent regulation of p21/WAF1 by transforming growth factor-beta

1 reference

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13 September 2017

Identification of a gadd45beta 3' enhancer that mediates SMAD3- and SMAD4-dependent transcriptional induction by transforming growth factor beta

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13 September 2017

Differential regulation of TGF-beta signaling through Smad2, Smad3 and Smad4

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Regulation of TGF-beta signaling and its roles in progression of tumors

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13 September 2017

An endogenous inhibitor of focal adhesion kinase blocks Rac1/JNK but not Ras/ERK-dependent signaling in vascular smooth muscle cells

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Current molecular models for NADPH oxidase regulation by Rac GTPase

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13 September 2017

Gene expression profiles of pancreatic cancer and stromal desmoplasia

1 reference

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13 September 2017

Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members

1 reference

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13 September 2017

Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts

1 reference

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13 September 2017

The Src family kinase inhibitors PP2 and PP1 block TGF-beta1-mediated cellular responses by direct and differential inhibition of type I and type II TGF-beta receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3112431

14 September 2017

Smad-dependent GADD45beta expression mediates delayed activation of p38 MAP kinase by TGF-beta

1 reference

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14 September 2017

Up-regulation of L1CAM in pancreatic duct cells is transforming growth factor beta1- and slug-dependent: role in malignant transformation of pancreatic cancer

1 reference

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14 September 2017

Keratinocyte-specific Smad2 ablation results in increased epithelial-mesenchymal transition during skin cancer formation and progression

1 reference

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14 September 2017

Identification of the gene transcription and apoptosis mediated by TGF-beta-Smad2/3-Smad4 signaling

1 reference

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14 September 2017

Dissecting the role of TGF-beta type I receptor/ALK5 in pancreatic ductal adenocarcinoma: Smad activation is crucial for both the tumor suppressive and prometastatic function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3112431

14 September 2017

Novel permissive role of epidermal growth factor in transforming growth factor beta (TGF-beta) signaling and growth suppression. Mediation by stabilization of TGF-beta receptor type II.

1 reference

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14 September 2017

Adhesion and Rac1-dependent regulation of biglycan gene expression by transforming growth factor-beta. Evidence for oxidative signaling through NADPH oxidase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3112431

14 September 2017

Transforming growth factor-beta (TGF-beta) type I receptor/ALK5-dependent activation of the GADD45beta gene mediates the induction of biglycan expression by TGF-beta

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3112431

14 September 2017

Endogenous control of cell cycle progression by autocrine transforming growth factor beta in breast cancer cells

1 reference

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14 September 2017

Expression profiling of the influence of RAS mutants on the TGFB1-induced phenotype of the pancreatic cancer cell line PANC-1.

1 reference

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14 September 2017

TGFbeta1 represses proliferation of pancreatic carcinoma cells which correlates with Smad4-independent inhibition of ERK activation

1 reference

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25 September 2017

Role of Smad proteins and transcription factor Sp1 in p21(Waf1/Cip1) regulation by transforming growth factor-beta.

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25 September 2017

TGFbeta-induced growth inhibition involves cell cycle inhibitor p21 and pRb independent from p15 expression.

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25 September 2017

Induction of apoptosis by DPC4, a transcriptional factor regulated by transforming growth factor-beta through stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) signaling pathway

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25 September 2017

Functional significance of Smad2 in regulating basal keratinocyte migration during wound healing

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17 June 2018

Smad4/DPC4-dependent regulation of biglycan gene expression by transforming growth factor-beta in pancreatic tumor cells

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17 June 2018

TGF-beta-1 up-regulates cyclin D1 expression in COLO-357 cells, whereas suppression of cyclin D1 levels is associated with down-regulation of the type I TGF-beta receptor

1 reference

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Requirement for Rac1 in a K-ras induced lung cancer in the mouse.

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21 August 2018

Src activation is not necessary for transforming growth factor (TGF)-beta-mediated epithelial to mesenchymal transitions (EMT) in mammary epithelial cells. PP1 directly inhibits TGF-beta receptors I and II.

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21 August 2018

Autocrine and exogenous transforming growth factor beta control cell cycle inhibition through pathways with different sensitivity.

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21 August 2018

Deregulation of the Rho GTPase, Rac1, suppresses cyclin-dependent kinase inhibitor p21(CIP1) levels in androgen-independent human prostate cancer cells.

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21 August 2018

Attenuation of the TGF-beta-Smad signaling pathway in pancreatic tumor cells confers resistance to TGF-beta-induced growth arrest.

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21 August 2018

p38 mitogen-activated protein kinase is required for TGFbeta-mediated fibroblastic transdifferentiation and cell migration.

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Functional characterization of transforming growth factor beta signaling in Smad2- and Smad3-deficient fibroblasts

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Bcl-XL protects pancreatic adenocarcinoma cells against CD95- and TRAIL-receptor-mediated apoptosis

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Induction of p21waf1 expression and growth inhibition by transforming growth factor beta involve the tumor suppressor gene DPC4 in human pancreatic adenocarcinoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21624123

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of SIS3, a novel specific inhibitor of Smad3, and its effect on transforming growth factor-beta1-induced extracellular matrix expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/21624123

12 December 2020

based on heuristic

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9 September 2019

https://scigraph.springernature.com/pub.10.1186/1476-4598-10-67

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https://api.fatcat.wiki/v0/release/ebafc4aqnvbrhkyana2xv4ctby

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