STAT3 plays a critical role in KRAS-induced pancreatic tumorigenesis. (Q39540918)

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1 February 2020

title

STAT3 plays a critical role in KRAS-induced pancreatic tumorigenesis (English)

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2

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David E. Levy

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author name string

Ryan B Corcoran

1

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Vikram Deshpande

3

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Alexandros Tzatsos

4

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Claudius Conrad

5

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1 February 2020

Cyril H Benes

6

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1 February 2020

Jeffrey Settleman

8

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Jeffrey A Engelman

9

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Nabeel Bardeesy

10

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1 February 2020

language of work or name

English

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publication date

17 May 2011

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1 February 2020

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1 February 2020

volume

71

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issue

14

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page(s)

5020-5029

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Enhanced sensitivity of pancreatic cancer cells to concurrent inhibition of aberrant signal transducer and activator of transcription 3 and epidermal growth factor receptor or Src.

1 February 2020

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STAT3 as a central mediator of neoplastic cellular transformation

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Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse

13 September 2017

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Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice

13 September 2017

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Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesis

13 September 2017

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Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse

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Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma

13 September 2017

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Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors

13 September 2017

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13 September 2017

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13 September 2017

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13 September 2017

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13 September 2017

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14 September 2017

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14 September 2017

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Persistent expression of PDX-1 in the pancreas causes acinar-to-ductal metaplasia through Stat3 activation

25 September 2017

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K-ras mutations in pancreatic ductal proliferative lesions

15 June 2018

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Establishment and characterization of a unique human cell line that proliferates dependently on GM-CSF, IL-3, or erythropoietin

15 June 2018

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Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-beta signaling.

15 June 2018

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The transcription factor Stat3 is dispensable for pancreatic beta-cell development and function.

21 August 2018

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Activated signal transducer and activator of transcription 3 (STAT3) supports the malignant phenotype of human pancreatic cancer.

21 August 2018

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STAT3 is a negative regulator of granulopoiesis but is not required for G-CSF-dependent differentiation

21 August 2018

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Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis

4 November 2018

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12 December 2020

Blockade of constitutively activated Janus kinase/signal transducer and activator of transcription-3 pathway inhibits growth of human pancreatic cancer

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12 December 2020

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12 December 2020

p16 and K-ras gene mutations in the intraductal precursors of human pancreatic adenocarcinoma

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12 December 2020

Pancreatic duct epithelial cell isolation and cultivation in two-dimensional and three-dimensional culture systems

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12 December 2020

10.1158/0008-5472.CAN-11-0908

Identifiers

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