Targeting SVCT for enhanced drug absorption: synthesis and in vitro evaluation of a novel vitamin C conjugated prodrug of saquinavir. (Q39542690)

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1 February 2020

title

Targeting SVCT for enhanced drug absorption: synthesis and in vitro evaluation of a novel vitamin C conjugated prodrug of saquinavir (English)

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1 February 2020

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4

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6

Dhananjay Pal

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author name string

Shuanghui Luo

1

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Zhiying Wang

2

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Mitesh Patel

3

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Xiaodong Zhu

5

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Ashim K Mitra

7

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language of work or name

English

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publication date

7 May 2011

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International Journal of Pharmaceutics

1 February 2020

published in

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volume

414

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issue

1-2

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page(s)

77-85

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Prodrug and conjugate drug delivery strategies for improving HIV/AIDS therapy.

1 February 2020

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Activity of a sodium-dependent vitamin C transporter (SVCT) in MDCK-MDR1 cells and mechanism of ascorbate uptake

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Polarized localization of vitamin C transporters, SVCT1 and SVCT2, in epithelial cells

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Quantitative determination of saquinavir from Caco-2 cell monolayers by HPLC-UV. High performance liquid chromatography

13 September 2017

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Up-regulation and polarized expression of the sodium-ascorbic acid transporter SVCT1 in post-confluent differentiated CaCo-2 cells

13 September 2017

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Targeted prodrug design to optimize drug delivery

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Saquinavir soft-gel capsule: an updated review of its use in the management of HIV infection

13 September 2017

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Cloning and functional characterization of the human sodium-dependent vitamin C transporters hSVCT1 and hSVCT2

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Human Na(+)-dependent vitamin C transporter 1 (hSVCT1): primary structure, functional characteristics and evidence for a non-functional splice variant

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A family of mammalian Na+-dependent L-ascorbic acid transporters

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Suppression of human immunodeficiency virus replication by ascorbate in chronically and acutely infected cells

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Evasion of P-gp mediated cellular efflux and permeability enhancement of HIV-protease inhibitor saquinavir by prodrug modification

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10.1016/J.IJPHARM.2011.05.001

21 August 2018

Identifiers

DOI

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1 February 2020

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PubMed publication ID

21571053

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