Induction of vesicular steatosis by amiodarone and tetracycline is associated with up-regulation of lipogenic genes in HepaRG cells (Q39578297)

13 September 2017

Induction of vesicular steatosis by amiodarone and tetracycline is associated with up-regulation of lipogenic genes in HepaRG cells (English)

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13 September 2017

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Sébastien Anthérieu

1

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13 September 2017

Alexandra Rogue

2

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13 September 2017

Bernard Fromenty

3

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13 September 2017

André Guillouzo

4

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13 September 2017

Marie-Anne Robin

5

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13 September 2017

language of work or name

English

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publication date

2 May 2011

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13 September 2017

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13 September 2017

53

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13 September 2017

6

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13 September 2017

1895-1905

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Nonalcoholic fatty liver disease: from steatosis to cirrhosis

13 September 2017

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Lipid metabolism and liver inflammation. II. Fatty liver disease and fatty acid oxidation

21 January 2018

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Applications of cytotoxicity assays and pre-lethal mechanistic assays for assessment of human hepatotoxicity potential

21 January 2018

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Cationic amphiphilic drug-induced phospholipidosis

21 January 2018

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Cytometric analysis for drug-induced steatosis in HepG2 cells.

21 January 2018

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Enhanced steatosis by nuclear receptor ligands: a study in cultured human hepatocytes and hepatoma cells with a characterized nuclear receptor expression profile.

21 January 2018

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Expression of cytochromes P450, conjugating enzymes and nuclear receptors in human hepatoma HepaRG cells

21 January 2018

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Stable expression, activity, and inducibility of cytochromes P450 in differentiated HepaRG cells

21 January 2018

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Histopathologic analysis of suspected amiodarone hepatotoxicity

21 January 2018

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Inhibition of mitochondrial beta-oxidation as a mechanism of hepatotoxicity

21 January 2018

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Infection of a human hepatoma cell line by hepatitis B virus

21 January 2018

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Transdifferentiation of hepatocyte-like cells from the human hepatoma HepaRG cell line through bipotent progenitor.

21 January 2018

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Dose- and time-dependent effects of phenobarbital on gene expression profiling in human hepatoma HepaRG cells

21 January 2018

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Microarray analyses and molecular profiling of steatosis induction in immortalized human hepatocytes

21 January 2018

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Differential effect of oleic and palmitic acid on lipid accumulation and apoptosis in cultured hepatocytes

21 January 2018

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Steady-state serum amiodarone concentrations: relationships with antiarrhythmic efficacy and toxicity.

21 January 2018

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21 January 2018

Liver lipid metabolism

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A novel pregnane X receptor and S14-mediated lipogenic pathway in human hepatocyte.

21 January 2018

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In vitro assay for drug-induced hepatosteatosis using rat primary hepatocytes, a fluorescent lipid analog and gene expression analysis

21 January 2018

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Gene expression in human NAFLD.

21 January 2018

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Up-regulation of ADRP in fatty liver in human and liver steatosis in mice fed with high fat diet.

21 January 2018

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Increased lipolysis in adipose tissues is associated with elevation of systemic free fatty acids and insulin resistance in perilipin null mice

21 January 2018

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Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance

21 January 2018

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Genes involved in fatty acid partitioning and binding, lipolysis, monocyte/macrophage recruitment, and inflammation are overexpressed in the human fatty liver of insulin-resistant subjects.

21 January 2018

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A toxicogenomic approach to drug-induced phospholipidosis: analysis of its induction mechanism and establishment of a novel in vitro screening system

21 January 2018

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Non-alcoholic steatohepatitis: impaired antipyrine metabolism and hypertriglyceridaemia may be clues to its pathogenesis

21 January 2018

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Relationship between in vivo chlorzoxazone hydroxylation, hepatic cytochrome P450 2E1 content and liver injury in obese non-alcoholic fatty liver disease patients

21 January 2018

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Reduction in hepatic cytochrome P-450 is correlated to the degree of liver fat content in animal models of steatosis in the absence of inflammation.

21 January 2018

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Inhibitory effects of amiodarone and its N-deethylated metabolite on human cytochrome P450 activities: prediction of in vivo drug interactions

21 January 2018

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Roles of phosphatidate phosphatase enzymes in lipid metabolism

21 January 2018

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Determination of phospholipidosis potential based on gene expression analysis in HepG2 cells

21 January 2018

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Effects of steatosis on drug-metabolizing capability of primary human hepatocytes

21 January 2018

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Evolving concepts in liver tissue modeling and implications for in vitro toxicology

21 January 2018

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7 January 2021

Inhibition of the mitochondrial oxidation of fatty acids by tetracycline in mice and in man: Possible role in microvesicular steatosis induced by this antibiotic

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7 January 2021

Cell-generated nitric oxide inactivates rat hepatocyte mitochondria in vitro but reacts with hemoglobin in vivo

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7 January 2021

Distribution of amiodarone and its metabolite, desethylamiodarone, in human tissues

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7 January 2021

Genomic cluster and network analysis for predictive screening for hepatotoxicity

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7 January 2021

Acute hepatotoxicity: a predictive model based on focused illumina microarrays

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7 January 2021

Identifiers

DOI

10.1002/HEP.24290

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13 September 2017

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