alpha-1-Antitrypsin and the pathogenesis of emphysema (Q39593971)

13 September 2017

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title

alpha-1-Antitrypsin and the pathogenesis of emphysema (English)

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13 September 2017

R A Stockley

1

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13 September 2017

publication date

1 January 1987

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13 September 2017

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13 September 2017

volume

165

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13 September 2017

issue

2

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13 September 2017

page(s)

61-77

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Proteinase inhibitory function in inflammatory lung disease. I. Acute bacterial pneumonia

13 September 2017

cites work

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Crossref

https://api.crossref.org/works/10.1007%2FBF02714424

Proteolytic Enzymes, their Inhibitors and Lung Diseases

21 January 2018

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Crossref

https://api.crossref.org/works/10.1007%2FBF02714424

Ehlers-Danlos syndrome with abnormal collagen fibrils, sinus of Valsalva aneurysms, myocardial infarction, panacinar emphysema and cerebral heterotopias.

21 January 2018

1 reference

12 December 2020

Cathepsin B-like cysteine proteinase activity in sputum and bronchoalveolar lavage samples: relationship to inflammatory cells and effects of corticosteroids and antibiotic treatment

1 reference

12 December 2020

Concentration of bronchoalveolar lavage fluid by ultrafiltration: evidence of differential protein loss and functional inactivation of proteinase inhibitors

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12 December 2020

The role of oxidative processes in emphysema

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12 December 2020

EXPERIMENTAL EMPHYSEMA: ITS PRODUCTION WITH PAPAIN IN NORMAL AND SILICOTIC RATS

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12 December 2020

Alpha,-antitrypsin and leukocyte elastase in infected and noninfected sputum

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12 December 2020

Measurement of soluble proteins in lung secretions

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12 December 2020

Neutrophils degrade subendothelial matrices in the presence of alpha-1-proteinase inhibitor. Cooperative use of lysosomal proteinases and oxygen metabolites

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12 December 2020

Familial hypogammaglobulinemia. Genetic linkage with alpha 1-antitrypsin deficiency

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12 December 2020

Proteolysis by neutrophils. Relative importance of cell-substrate contact and oxidative inactivation of proteinase inhibitors in vitro

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12 December 2020

Antioxidant activity of some antiproteases

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12 December 2020

Comparison of live human neutrophil and alveolar macrophage elastolytic activity in vitro. Relative resistance of macrophage elastolytic activity to serum and alveolar proteinase inhibitors

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12 December 2020

Relation of Protease Inhibitor Phenotypes to Obstructive Lung Diseases in a Community

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12 December 2020

ELISA for quantitative measurement of low-molecular-weight bronchial protease inhibitor in human sputum

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12 December 2020

Desmosine radioimmunoassay for measuring elastin degradation in vivo

1 reference

12 December 2020

Inflammatory and immune processes in the human lung in health and disease: evaluation by bronchoalveolar lavage

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12 December 2020

Pulmonary function associated with the Mmalton deficient variant of alpha 1-antitrypsin

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12 December 2020

Translation and processing of normal (PiMM) and abnormal (PiZZ) human alpha 1-antitrypsin

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12 December 2020

The effect of leucocyte elastase on the immunoelectrophoretic behaviour of alpha 1-antitrypsin

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12 December 2020

Functional alpha 1-protease inhibitor in the lower respiratory tract of cigarette smokers is not decreased

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12 December 2020

A comparative study of the severity of emphysema in necropsy populations in three different countries.

1 reference

12 December 2020

The induction of emphysema with elastase. II. Changes in connective tissue

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12 December 2020

1 -Antitrypsin deficiency: a variant with no detectable 1 -antitrypsin

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12 December 2020

Qualitative studies of lung lavage alpha 1-proteinase inhibitor

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12 December 2020

Antielastases of the human alveolar structures. Implications for the protease-antiprotease theory of emphysema

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12 December 2020

Ozone inactivation of human alpha 1-proteinase inhibitor

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12 December 2020

Lung function studies in asymptomatic individuals with moderately (Pi SZ) and severely (Pi Z) reduced levels of alpha1-antitrypsin

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12 December 2020

Xenopusoocytes can synthesise but do not secrete the Z variant of human α1-antitrypsin

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12 December 2020

Protease inhibitors in tracheobronchial secretions

1 reference

12 December 2020

Human alveolar macrophages produce a fibroblast-like collagenase and collagenase inhibitor

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12 December 2020

Natural History and Life Expectancy in Severe Alpha1-Antitrypsin Deficiency, Pi Z

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12 December 2020

Immunologic measurement of elastin-derived peptides in human serum

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12 December 2020

Sputum sol-phase proteins and elastase activity in patients with cystic fibrosis.

1 reference

12 December 2020

Protease and elastase of Pseudomonas aeruginosa: inactivation of human plasma alpha 1-proteinase inhibitor

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12 December 2020

Demonstration of a free elastolytic metalloenzyme in human lung lavage fluid and its relationship to alpha 1-antiprotease

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12 December 2020

Potential mechanism of emphysema: alpha 1-proteinase inhibitor recovered from lungs of cigarette smokers contains oxidized methionine and has decreased elastase inhibitory capacity

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12 December 2020

Alveolar macrophage function and inflammatory stimuli in smokers with and without obstructive lung disease

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12 December 2020

The functional activity of alpha 1-proteinase inhibitor in bronchoalveolar lavage fluids from healthy human smokers and non-smokers

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12 December 2020

Pulmonary function in nonsmoking subjects with alpha1 antitrypsin deficiency (MZ phenotype)

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12 December 2020

Studies in alpha 1-antitrypsin deficiency.

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12 December 2020

Lung lavage fluid from patients with alpha 1-proteinase inhibitor deficiency or chronic obstructive bronchitis: anti-elastase function and cell profile

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12 December 2020

Replacement therapy of alpha 1-antitrypsin deficiency. Reversal of protease-antiprotease imbalance within the alveolar structures of PiZ subjects

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12 December 2020

Generalized elastolysis (cutis laxa)

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12 December 2020

Regulation of alpha 1 proteinase inhibitor function by rabbit alveolar macrophages. Evidence for proteolytic rather than oxidative inactivation

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12 December 2020

Smoking, lung function, and alpha 1-antitrypsin deficiency.

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12 December 2020

Alpha-1-antitrypsin deficiency presenting as bronchiectasis

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12 December 2020

Deficiency of the Chemotactic Factor Inactivator in Human Sera with α1-Antitrypsin Deficiency

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12 December 2020

Selective IgA deficiency and Pi ZZ-antitrypsin deficiency. Association with recurrent sinopulmonary infections, emphysema, and bronchiectasis

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12 December 2020

Oxidant injury of the extracellular matrix: potential role in the pathogenesis of pulmonary emphysema

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12 December 2020

The lung of the copper-deficient rat. A model for developmental pulmonary emphysema

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12 December 2020

A genetically engineered mutant of alpha 1-antitrypsin protects connective tissue from neutrophil damage and may be useful in lung disease

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12 December 2020

Basic and clinical aspects of the alpha1-antitrypsin

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12 December 2020

Cigarette Smoke Inhalation Decreases α 1 -Antitrypsin Activity in Rat Lung

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12 December 2020

Cigarette Smoking Induces Functional Antiprotease Deficiency in the Lower Respiratory Tract of Humans

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12 December 2020

Elastolytic activity of sputum and its relation to purulence and to lung function in patients with bronchiectasis

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12 December 2020

The induction of pulmonary emphysema with human leukocyte elastase

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12 December 2020

The Familial Occurrence of Chronic Obstructive Pulmonary Disease

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12 December 2020

Prospective study of children with alpha 1-antitrypsin deficiency: eight-year-old follow-up

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12 December 2020

In vitro suppression of serum elastase-inhibitory capacity by reactive oxygen species generated by phagocytosing polymorphonuclear leukocytes

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12 December 2020

Relationship between elastolytic acitivity and experimental emphysema-induced properties of papain preparations

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12 December 2020

Interaction between alpha 1 antitrypsin and lymphocyte surface proteases: immunoregulatory effects

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12 December 2020

Dermal connective tissue in patients with chronic obstructive airways disease.

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12 December 2020

Levels of elastase activity in bronchoalveolar lavage fluids of healthy smokers and nonsmokers

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12 December 2020

The effect of catalase and methionine-S-oxide reductase on oxidised alpha 1-proteinase inhibitor

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12 December 2020

Chemotactic activity of elastin-derived peptides

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12 December 2020

Interrelationships between serum chemotactic factor inactivator, alpha 1-antitrypsin deficiency, and chronic obstructive lung disease

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12 December 2020

James Jackson, Jr., the young pulmonologist who described familial emphysema. An historical footnote.

1 reference

12 December 2020

A model of decreased functional alpha-1-proteinase inhibitor. Pulmonary pathology of dogs exposed to chloramine T.

1 reference

12 December 2020

Low Molecular Mass Bronchial Proteinase Inhibitor and α1-Proteinase Inhibitor in Sputum and Bronchoalveolar Lavage

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12 December 2020

Oxidation of alpha 1-proteinase inhibitor as a major, contributing factor in the development of pulmonary emphysema

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12 December 2020

A study of plasma proteins in the sol phase of sputum from patients with chronic bronchitis

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12 December 2020

Acute effect of smoking on the functional activity of alpha1-protease inhibitor in bronchoalveolar lavage fluid

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12 December 2020

Neutrophil lysosomal elastase activity in normal subjects and in patients with chronic obstructive pulmonary disease

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12 December 2020

The presence of neutrophil elastase and evidence of oxidation activity in bronchoalveolar lavage fluid of patients with adult respiratory distress syndrome

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12 December 2020

Genetic and Environmental Determinants of Chronic Obstructive Pulmonary Disease

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12 December 2020

Collaborative study to assess risk of lung disease in Pi MZ phenotype subjects

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12 December 2020

Is the PiF allele of alpha 1-antitrypsin associated with pulmonary disease?

1 reference

12 December 2020

Immunologic identification of elastin-derived peptides in the serums of dogs with experimental emphysema

1 reference

12 December 2020

Possible mechanisms of emphysema in smokers. In vitro suppression of serum elastase-inhibitory capacity by fresh cigarette smoke and its prevention by antioxidants

1 reference

12 December 2020

Cigarette Smoke Components are not very Effective in Directly Inactivating α1-Proteinase Inhibitor

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12 December 2020

Tissue inhibitor of metalloproteinases and collagenase inhibitory activity in lung secretions from patients with chronic obstructive bronchitis: effect of corticosteroid treatment

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12 December 2020

Emphysema-like changes in the lungs of starved rats

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12 December 2020

A copper-deficient, zinc-supplemented diet produces emphysema in pigs

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12 December 2020

Studies on the elastase-serum protein interaction. I. Molecular identity of the inhibitors in human serum and direct demonstration of inhibitor-elastase complexes by zone and immunoelectrophoresis

1 reference

12 December 2020

Familial prevalence of chronic obstructive pulmonary disease in a matched pair study

1 reference

12 December 2020

Combined α1-Antitrypsin and α2-Macroglobulin Deficiency Syndrome: Lightmicroscopic Evidence of Collagenolytic, Elastolytic and Myolytic Tissue Lesions

1 reference

12 December 2020

DNA restriction fragments associated with alpha 1-antitrypsin indicate a single origin for deficiency allele PI Z.

1 reference

12 December 2020

Pathogenesis of the adult respiratory distress syndrome. Evidence of oxidant activity in bronchoalveolar lavage fluid

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12 December 2020

The effect of lathyrogens on the evolution of elastase-induced emphysema

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12 December 2020

Localisation of a low-molecular-weight bronchial protease inhibitor in the peripheral human lung

1 reference

12 December 2020

The influence of cigarette smoking and its withdrawal on the annual change of lung function in pulmonary emphysema.

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12 December 2020

Identifiers

DOI

10.1007/BF02714424

1 reference

13 September 2017

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