GNAS complex locus (Q39627001)

http://www.ebi.ac.uk/interpro/protein/P63095

G-protein alpha subunit, group S

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P63095

P-loop containing nucleoside triphosphate hydrolase

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P63095

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

1 reference

17 November 2021

1 reference

17 November 2021

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63095

G protein-coupled receptor binding

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63095

G-protein alpha-subunit binding

1 reference

9 May 2019

Two overlapping reading frames in a single exon encode interacting proteins--a novel way of gene usage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63095

insulin-like growth factor receptor binding

IPI

3 references

9 May 2019

Identification and characterization of GIV, a novel Galpha i/s-interacting protein found on COPI, endoplasmic reticulum-Golgi transport vesicles

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63095

9 May 2019

Interaction of alpha1-syntrophin with multiple isoforms of heterotrimeric G protein alpha subunits

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63095

9 May 2019

Two overlapping reading frames in a single exon encode interacting proteins--a novel way of gene usage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63095

4 references

9 May 2019

Molecular cloning and sequence determination of cDNAs for alpha subunits of the guanine nucleotide-binding proteins Gs, Gi, and Go from rat brain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63095

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63095

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63095

9 May 2019

Functional characterization of heterotrimeric G-proteins in rat diaphragm muscle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63095

adenylate cyclase activator activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63095

guanyl nucleotide binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63095

protein domain specific binding

1 reference

9 May 2019

Two overlapping reading frames in a single exon encode interacting proteins--a novel way of gene usage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63095

G-protein beta-subunit binding

IPI

1 reference

9 May 2019

Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Specific activation of Gsalpha by an NDPK B.Gbetagamma complex in H10 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63095

mu-type opioid receptor binding

3 references

9 May 2019

Ultra-low dose naloxone restores the antinociceptive effect of morphine in pertussis toxin-treated rats by reversing the coupling of mu-opioid receptors from Gs-protein to coupling to Gi-protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63095

9 May 2019

Gbetagamma that interacts with adenylyl cyclase in opioid tolerance originates from a Gs protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63095

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63095

G protein betagamma subunits interact with alphabeta- and gamma-tubulin and play a role in microtubule assembly in PC12 cells

alpha-tubulin binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63095

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63095

alkylglycerophosphoethanolamine phosphodiesterase activity

1 reference

9 May 2019

The heterotrimeric G protein subunits Gα(q) and Gβ(1) have lysophospholipase D activity

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63095

corticotropin-releasing hormone receptor 1 binding

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q792G6

G-protein beta/gamma-subunit complex binding

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q792G6

1 reference

9 May 2019

Two overlapping reading frames in a single exon encode interacting proteins--a novel way of gene usage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63095

1 reference

9 May 2019

G-protein-coupled receptor signaling components localize in both sarcolemmal and intracellular caveolin-3-associated microdomains in adult cardiac myocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63095

1 reference

9 May 2019

Glucagon-mediated internalization of serine-phosphorylated glucagon receptor and Gsalpha in rat liver

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63095

1 reference

9 May 2019

A proline-rich region and nearby cysteine residues target XLalphas to the Golgi complex region

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63095

heterotrimeric G-protein complex

3 references

9 May 2019

Live cell imaging of Gs and the beta2-adrenergic receptor demonstrates that both alphas and beta1gamma7 internalize upon stimulation and exhibit similar trafficking patterns that differ from that of the beta2-adrenergic receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63095

9 May 2019

Functional reconstitution of G-protein-coupled receptor-mediated adenylyl cyclase activation by a baculoviral co-display system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63095

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63095

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63095

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63095

9 May 2019

Partial rescue of functional interactions of a nonpalmitoylated mutant of the G-protein G alpha s by fusion to the beta-adrenergic receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63095

9 May 2019

Live cell imaging of Gs and the beta2-adrenergic receptor demonstrates that both alphas and beta1gamma7 internalize upon stimulation and exhibit similar trafficking patterns that differ from that of the beta2-adrenergic receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63095

9 May 2019

Glucagon-mediated internalization of serine-phosphorylated glucagon receptor and Gsalpha in rat liver

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63095

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63095

9 May 2019

G-protein-coupled receptor signaling components localize in both sarcolemmal and intracellular caveolin-3-associated microdomains in adult cardiac myocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63095

9 May 2019

VIP induces the translocation and degradation of the alpha subunit of Gs protein in rat pituitary GH4C1 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63095

COPI-coated Golgi to ER transport vesicle

1 reference

9 May 2019

Identification and characterization of GIV, a novel Galpha i/s-interacting protein found on COPI, endoplasmic reticulum-Golgi transport vesicles

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63095

1 reference

9 May 2019

G-protein-coupled receptor signaling components localize in both sarcolemmal and intracellular caveolin-3-associated microdomains in adult cardiac myocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63095

1 reference

9 May 2019

Peripheral projections of NESP55 containing neurons in the rat sympathetic ganglia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63095

1 reference

9 May 2019

Chronic treatment with escitalopram but not R-citalopram translocates Galpha(s) from lipid raft domains and potentiates adenylyl cyclase: a 5-hydroxytryptamine transporter-independent action of this antidepressant compound

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63095

perinuclear region of cytoplasm

1 reference

9 May 2019

Live cell imaging of Gs and the beta2-adrenergic receptor demonstrates that both alphas and beta1gamma7 internalize upon stimulation and exhibit similar trafficking patterns that differ from that of the beta2-adrenergic receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63095

1 reference

9 May 2019

Live cell imaging of Gs and the beta2-adrenergic receptor demonstrates that both alphas and beta1gamma7 internalize upon stimulation and exhibit similar trafficking patterns that differ from that of the beta2-adrenergic receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63095

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q792G6

3 references

8 April 2019

Live cell imaging of Gs and the beta2-adrenergic receptor demonstrates that both alphas and beta1gamma7 internalize upon stimulation and exhibit similar trafficking patterns that differ from that of the beta2-adrenergic receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q792G6

8 April 2019

Glucagon-mediated internalization of serine-phosphorylated glucagon receptor and Gsalpha in rat liver

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q792G6

8 April 2019

Partial rescue of functional interactions of a nonpalmitoylated mutant of the G-protein G alpha s by fusion to the beta-adrenergic receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q792G6

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q792G6

1 reference

8 April 2019

G-protein-coupled receptor signaling components localize in both sarcolemmal and intracellular caveolin-3-associated microdomains in adult cardiac myocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q792G6

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q792G6

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q792G6

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q792G6

positive regulation of protein phosphorylation

biological process

1 reference

9 May 2019

Transgenic overexpression of the extra-large Gsα variant XLαs enhances Gsα-mediated responses in the mouse renal proximal tubule in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63095

regulation of transcription by RNA polymerase II

1 reference

9 May 2019

Antagonist minigenes identify genes regulated by parathyroid hormone through G protein-selective and G protein co-regulated mechanisms in osteoblastic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63095

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63095

adenylate cyclase-activating G protein-coupled receptor signaling pathway

4 references

9 May 2019

Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Specific activation of Gsalpha by an NDPK B.Gbetagamma complex in H10 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63095

9 May 2019

Glucagon-mediated internalization of serine-phosphorylated glucagon receptor and Gsalpha in rat liver

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63095

9 May 2019

Gbetagamma that interacts with adenylyl cyclase in opioid tolerance originates from a Gs protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63095

9 May 2019

Indomethacin enhances shuttling of aquaporin-2 despite decreased abundance in rat kidney

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63095

adenylate cyclase-activating dopamine receptor signaling pathway

positive regulation of cell population proliferation

1 reference

9 May 2019

Conditional overexpression of the wild-type Gs alpha as the gsp oncogene initiates chronic extracellularly regulated kinase 1/2 activation and hormone hypersecretion in pituitary cell lines

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63095

positive regulation of sodium ion transport

1 reference

9 May 2019

Modulation of rat cardiac sodium channel by the stimulatory G protein alpha subunit

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63095

negative regulation of renal sodium excretion

1 reference

9 May 2019

Functional selectivity of central Gα-subunit proteins in mediating the cardiovascular and renal excretory responses evoked by central α(2) -adrenoceptor activation in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63095

positive regulation of GTPase activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63095

positive regulation of cAMP-mediated signaling

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63095

negative regulation of blood pressure

1 reference

9 May 2019

Functional selectivity of central Gα-subunit proteins in mediating the cardiovascular and renal excretory responses evoked by central α(2) -adrenoceptor activation in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63095

Transgenic overexpression of the extra-large Gsα variant XLαs enhances Gsα-mediated responses in the mouse renal proximal tubule in vivo

calcium ion homeostasis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63095

cellular response to prostaglandin E stimulus

1 reference

9 May 2019

Functional reconstitution of G-protein-coupled receptor-mediated adenylyl cyclase activation by a baculoviral co-display system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63095

cellular response to catecholamine stimulus

1 reference

9 May 2019

Functional reconstitution of G-protein-coupled receptor-mediated adenylyl cyclase activation by a baculoviral co-display system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63095

adenylate cyclase-activating adrenergic receptor signaling pathway

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63095

positive regulation of cold-induced thermogenesis

1 reference

9 May 2019

G(s)alpha deficiency in adipose tissue leads to a lean phenotype with divergent effects on cold tolerance and diet-induced thermogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63095

G protein-coupled receptor signaling pathway

1 reference

8 April 2019

Alterations in hepatic glucagon receptor density and in Gsalpha and Gialpha2 protein content with diet-induced hepatic steatosis: effects of acute exercise

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q792G6

adenylate cyclase-activating dopamine receptor signaling pathway

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q792G6

response to parathyroid hormone

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q792G6