Alpha-synuclein, especially the Parkinson's disease-associated mutants, forms pore-like annular and tubular protofibrils (Q39632694)

13 September 2017

Alpha-synuclein, especially the Parkinson's disease-associated mutants, forms pore-like annular and tubular protofibrils (English)

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13 September 2017

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1

Hilal A Lashuel

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13 September 2017

Benjamin M Petre

2

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13 September 2017

Joseph Wall

3

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13 September 2017

Martha Simon

4

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13 September 2017

Richard J Nowak

5

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13 September 2017

Thomas Walz

6

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13 September 2017

Peter T Lansbury

7

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13 September 2017

language of work or name

English

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publication date

1 October 2002

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Journal of Molecular Biology

13 September 2017

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13 September 2017

322

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13 September 2017

1089-1102

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13 September 2017

5

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13 September 2017

From entropy to Duino

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https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900735-0

alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900735-0

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900735-0

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900735-0

Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900735-0

A Drosophila model of Parkinson's disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900735-0

Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900735-0

Inhibition of fibrillization and accumulation of prefibrillar oligomers in mixtures of human and mouse alpha-synuclein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900735-0

Effect of familial Parkinson's disease point mutations A30P and A53T on the structural properties, aggregation, and fibrillation of human alpha-synuclein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900735-0

Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900735-0

PAN, the proteasome-activating nucleotidase from archaebacteria, is a protein-unfolding molecular chaperone

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900735-0

Fibrils formed in vitro from alpha-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900735-0

Annular alpha-synuclein protofibrils are produced when spherical protofibrils are incubated in solution or bound to brain-derived membranes.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900735-0

A hydrophobic stretch of 12 amino acid residues in the middle of alpha-synuclein is essential for filament assembly.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900735-0

Vesicle permeabilization by protofibrillar alpha-synuclein: implications for the pathogenesis and treatment of Parkinson's disease.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900735-0

Staphylococcal alpha-toxin: formation of the heptameric pore is partially cooperative and proceeds through multiple intermediate stages

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900735-0

Beta-barrel pore-forming toxins: intriguing dimorphic proteins

7 January 2021

1 reference

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Mechanism of membrane insertion of a multimeric beta-barrel protein: perfringolysin O creates a pore using ordered and coupled conformational changes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900735-0

Mode of action of beta-barrel pore-forming toxins of the staphylococcal alpha-hemolysin family

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900735-0

Structural analysis of Alzheimer's beta(1-40) amyloid: protofilament assembly of tubular fibrils.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900735-0

Molecular structure of a fibrillar Alzheimer's A beta fragment.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900735-0

Amyloid fibrillogenesis: themes and variations

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900735-0

Protofibrils, the unifying toxic molecule of neurodegenerative disorders?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900735-0

Non-fibrillar oligomeric species of the amyloid ABri peptide, implicated in familial British dementia, are more potent at inducing apoptotic cell death than protofibrils or mature fibrils

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900735-0

Vesicle permeabilization by protofibrillar alpha-synuclein is sensitive to Parkinson's disease-linked mutations and occurs by a pore-like mechanism.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900735-0

Aerolysin--the ins and outs of a model channel-forming toxin.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900735-0

Molecular mechanism of neurodegeneration induced by Alzheimer's beta-amyloid protein: channel formation and disruption of calcium homeostasis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900735-0

Pore formation by beta-2-microglobulin: a mechanism for the pathogenesis of dialysis associated amyloidosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900735-0

Diversity of amyloid beta protein fragment [1-40]-formed channels.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900735-0

A nonfibrillar form of the fusogenic prion protein fragment [118-135] induces apoptotic cell death in rat cortical neurons.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900735-0

Amyloid beta protein forms ion channels: implications for Alzheimer's disease pathophysiology

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900735-0

Pore formation by the cytotoxic islet amyloid peptide amylin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900735-0

Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900735-0

SPIDER and WEB: processing and visualization of images in 3D electron microscopy and related fields

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900735-0

An improved function for fitting sedimentation velocity data for low-molecular-weight solutes

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900735-0

Boundary analysis in sedimentation velocity experiments.

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900735-0

Characterization of the transthyretin acid denaturation pathways by analytical ultracentrifugation: implications for wild-type, V30M, and L55P amyloid fibril formation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900735-0

Protein volumes and hydration effects. The calculations of partial specific volumes, neutron scattering matchpoints and 280-nm absorption coefficients for proteins and glycoproteins from amino acid sequences.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900735-0

Amyloid fibers are water-filled nanotubes

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900735-0

Pathology and biology of the Lewy body

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900735-0

inferred from DOI database lookup

7 January 2021

based on heuristic

Neuropathology of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900735-0

inferred from DOI database lookup

7 January 2021

based on heuristic

Accelerated oligomerization by Parkinson's disease linked alpha-synuclein mutants

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2836%2802%2900735-0

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1016/S0022-2836(02)00735-0

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13 September 2017

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