Role of pharmacokinetics in the outcome of infections (Q39639407)

13 September 2017

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title

Role of pharmacokinetics in the outcome of infections (English)

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13 September 2017

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Drusano GL

1

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PMCID

172162

13 September 2017

language of work or name

English

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publication date

1 March 1988

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Antimicrobial Agents and Chemotherapy

13 September 2017

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13 September 2017

32

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13 September 2017

3

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13 September 2017

289-297

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The Relation of Protein Binding to the Pharmacology and Antibacterial Activity of Penicillins X, G, Dihydro F, and K.

13 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=172162

Influence of serum protein binding and mode of administration on penetration of five cephalosporins into subcutaneous tissue fluid in humans

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=172162

Comparison of the pharmacokinetics of ceftazidime and moxalactam and their microbiological correlates in volunteers

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=172162

Comparative activities of piperacillin, ceftazidime, and amikacin, alone and in all possible combinations, against experimental Pseudomonas aeruginosa infections in neutropenic rats

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=172162

Continuous versus intermittent administration of ceftazidime in experimental Klebsiella pneumoniae pneumonia in normal and leukopenic rats

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=172162

Imipenem coadministered with cilastatin compared with moxalactam: integration of serum pharmacokinetics and microbiologic activity following single-dose administration to normal volunteers

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=172162

A Randomized Comparative Trial of Three Aminoglycosides—Comparison of Continuous Infusions of Gentamicin, Aaikacin and Sisomicin Combined with Carbenicillin in the Treatment of Infections in Neutropenic Patients with Malignancies

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=172162

Multiple-dose pharmacokinetics of imipenem-cilastatin

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=172162

Postantibiotic effect of imipenem on Pseudomonas aeruginosa

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=172162

Piperacillin or ticarcillin plus amikacin. A double-blind prospective comparison of empiric antibiotic therapy for febrile granulocytopenic cancer patients

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=172162

Empiric therapy with carbenicillin and gentamicin for febrile patients with cancer and granulocytopenia

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=172162

Comparative pharmacokinetics and serum bactericidal activity of mezlocillin, ticarcillin and piperacillin, with and without gentamicin

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=172162

A randomized study of carbenicillin plus cefamandole or tobramycin in the treatment of febrile episodes in cancer patients

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=172162

Early termination of a prospective, randomized trial comparing teicoplanin and flucloxacillin for treating severe staphylococcal infections

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=172162

Serum Dilution Test for Bactericidal Activity. II. Standardization and Correlation with Antimicrobial Assays and Susceptibility Tests

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=172162

The association of aminoglycoside plasma levels with mortality in patients with gram-negative bacteremia.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=172162

Integration of Selected Pharmacologic and Microbiologic Properties of Three New -Lactam Antibiotics: A Hypothesis for Rational Comparison

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=172162

Analysis of a new method for assessing activity of combinations of antimicrobials: area under the bactericidal activity curve

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=172162

Pharmacokinetics and pharmacodynamics of intravenous ciprofloxacin. Studies in vivo and in an in vitro dynamic model

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=172162

Clinical response to aminoglycoside therapy: importance of the ratio of peak concentration to minimal inhibitory concentration

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=172162

Correlation of predicted serum bactericidal activities and values measured in volunteers.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=172162

Simultaneous antibiotic levels in "breakthrough" gram-negative rod bacteremia

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=172162

Failure of a once-daily regimen of cefonicid for treatment of endocarditis due to Staphylococcus aureus.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=172162

Role for Dual Individualization with Cefmenoxime

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=172162

General principles of antibiotic tissue penetration

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=172162

In-vitro model for simultaneous simulation of the serum kinetics of two drugs with different half-lives.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=172162

Association of aminoglycoside plasma levels with therapeutic outcome in gram-negative pneumonia

21 August 2018

1 reference

12 December 2020

Postantibiotic suppression of bacterial growth

1 reference

12 December 2020

Significance of serum bactericidal activity in gram-negative bacillary bacteremia in patients with and without granulocytopenia

1 reference

12 December 2020

The relevance of pharmacokinetics to in-vitro models: protein binding--does it matter?

1 reference

12 December 2020

The influence of protein binding upon tissue fluid levels of six beta-lactam antibiotics

1 reference

12 December 2020

Selection of aminoglycoside-resistant variants of Pseudomonas aeruginosa in an in vivo model

1 reference

12 December 2020

Impact of dosing intervals on activity of gentamicin and ticarcillin against Pseudomonas aeruginosa in granulocytopenic mice

1 reference

12 December 2020

Constant infusions vs. intermittent doses of gentamicin against Pseudomonas aeruginosa in vitro

1 reference

12 December 2020

Anomalous effect of serum on the antimicrobial activity of cefoperazone

1 reference

12 December 2020

Efficacy of single-agent therapy with azlocillin, ticarcillin, and amikacin and beta-lactam/amikacin combinations for treatment of Pseudomonas aeruginosa bacteremia in granulocytopenic rats

1 reference

12 December 2020

Effect of protein binding on antibiotic activity in vivo

1 reference

12 December 2020

In-vivo assessment of in-vitro killing patterns of Pseudomonas aeruginosa

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12 December 2020

Antibacterial activity in serum and urine as a therapeutic guide in bacterial infections

1 reference

12 December 2020

Experience in monitoring gentamicin therapy during treatment of serious gram-negative sepsis

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12 December 2020

Postantibiotic effects

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12 December 2020

Basis and results of therapy with Beta-lactam antibiotics in experimental infections

1 reference

12 December 2020

Mezlocillin, ceftizoxime, and amikacin alone and in combination against six Enterobacteriaceae in a neutropenic site in rabbits

1 reference

12 December 2020

Identifiers

DOI

10.1128/AAC.32.3.289

1 reference

13 September 2017

1 reference

13 September 2017

1 reference

PMCID

172162