The peptidomimetic CXCR4 antagonist TC14012 recruits beta-arrestin to CXCR7: roles of receptor domains (Q39642723)

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15 February 2020

title

The peptidomimetic CXCR4 antagonist TC14012 recruits beta-arrestin to CXCR7: roles of receptor domains (English)

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15 February 2020

5

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15 February 2020

Camille Malouf

2

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15 February 2020

Daniel Sinnett

8

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15 February 2020

9

Nikolaus Heveker

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15 February 2020

author name string

Stéphanie Gravel

1

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15 February 2020

Philip E Boulais

3

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15 February 2020

Yamina A Berchiche

4

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15 February 2020

Nobutaka Fujii

6

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15 February 2020

Richard Leduc

7

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15 February 2020

language of work or name

English

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publication date

18 October 2010

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Journal of Biological Chemistry

15 February 2020

number of pages

5

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based on heuristic

inferred from page(s)

published in

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15 February 2020

volume

285

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15 February 2020

issue

49

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15 February 2020

page(s)

37939-37943

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Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists

15 February 2020

cites work

1 reference

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CXCR7 functions as a scavenger for CXCL12 and CXCL11

14 September 2017

1 reference

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Site-specific phosphorylation of CXCR4 is dynamically regulated by multiple kinases and results in differential modulation of CXCR4 signaling

14 September 2017

1 reference

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Beta-arrestin- but not G protein-mediated signaling by the "decoy" receptor CXCR7

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992227

Structural basis of the interaction between chemokine stromal cell-derived factor-1/CXCL12 and its G-protein-coupled receptor CXCR4.

14 September 2017

1 reference

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Bi- or multifunctional opioid peptide drugs

14 September 2017

1 reference

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AMD3100 is a CXCR7 ligand with allosteric agonist properties

14 September 2017

1 reference

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CXCR7, CXCR4 and CXCL12: an eccentric trio?

14 September 2017

1 reference

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Control of chemokine-guided cell migration by ligand sequestration

14 September 2017

1 reference

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Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7

14 September 2017

1 reference

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A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development

14 September 2017

1 reference

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The chemokine SDF-1/CXCL12 binds to and signals through the orphan receptor RDC1 in T lymphocytes

14 September 2017

1 reference

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beta-Arrestin-dependent constitutive internalization of the human chemokine decoy receptor D6.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992227

Lipid bilayer simulations of CXCR4 with inverse agonists and weak partial agonists

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992227

Phosphorylation-independent desensitization of GABA(B) receptor by GRK4

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992227

Development of specific CXCR4 inhibitors possessing high selectivity indexes as well as complete stability in serum based on an anti-HIV peptide T140.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2992227

Molecular interactions of cyclam and bicyclam non-peptide antagonists with the CXCR4 chemokine receptor

14 September 2017

1 reference

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A low-molecular-weight inhibitor against the chemokine receptor CXCR4: a strong anti-HIV peptide T140.

14 September 2017

1 reference

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Determinants for sensitivity of human immunodeficiency virus coreceptor CXCR4 to the bicyclam AMD3100

14 September 2017

1 reference

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Solution structure and basis for functional activity of stromal cell-derived factor-1; dissociation of CXCR4 activation from binding and inhibition of HIV-1.

14 September 2017

1 reference

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Synthesis and biological evaluation of selective CXCR4 antagonists containing alkene dipeptide isosteres

14 September 2017

1 reference

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Elucidation of CXCR7-mediated signaling events and inhibition of CXCR4-mediated tumor cell transendothelial migration by CXCR7 ligands

14 September 2017

1 reference

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Photolabeling identifies transmembrane domain 4 of CXCR4 as a T140 binding site

14 September 2017

1 reference

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Synthesis and application of fluorescein- and biotin-labeled molecular probes for the chemokine receptor CXCR4.

14 September 2017

1 reference

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High-throughput screening of G protein-coupled receptor antagonists using a bioluminescence resonance energy transfer 1-based beta-arrestin2 recruitment assay

14 September 2017

1 reference

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Monitoring agonist-promoted conformational changes of beta-arrestin in living cells by intramolecular BRET.

14 September 2017

1 reference

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Quantitative assessment of beta 1- and beta 2-adrenergic receptor homo- and heterodimerization by bioluminescence resonance energy transfer

14 September 2017

1 reference

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CXCR7 heterodimerizes with CXCR4 and regulates CXCL12-mediated G protein signaling.

25 September 2017

1 reference

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A crosstalk between intracellular CXCR7 and CXCR4 involved in rapid CXCL12-triggered integrin activation but not in chemokine-triggered motility of human T lymphocytes and CD34+ cells

21 August 2018

1 reference

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A point mutation that confers constitutive activity to CXCR4 reveals that T140 is an inverse agonist and that AMD3100 and ALX40-4C are weak partial agonists

21 August 2018

1 reference

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21 August 2018

Identifiers

DOI

10.1074/JBC.C110.147470

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15 February 2020

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15 February 2020

PubMed publication ID

20956518

1 reference