Reduced expression of DNA repair and redox signaling protein APE1/Ref-1 impairs human pancreatic cancer cell survival, proliferation, and cell cycle progression. (Q39648369)

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scientific article published on November 2010

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English	Reduced expression of DNA repair and redox signaling protein APE1/Ref-1 impairs human pancreatic cancer cell survival, proliferation, and cell cycle progression.	scientific article published on November 2010

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scholarly article

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15 February 2020

Reduced expression of DNA repair and redox signaling protein APE1/Ref-1 impairs human pancreatic cancer cell survival, proliferation, and cell cycle progression (English)

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15 February 2020

pancreatic cancer

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inferred from title

5

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15 February 2020

author name string

Yanlin Jiang

1

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15 February 2020

Shaoyu Zhou

2

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15 February 2020

George E Sandusky

3

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15 February 2020

Mark R Kelley

4

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15 February 2020

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1 November 2010

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15 February 2020

Cancer Investigation

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15 February 2020

28

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15 February 2020

9

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15 February 2020

885-895

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15 February 2020

Regulation of signal transducer and activator of transcription 3 enhanceosome formation by apurinic/apyrimidinic endonuclease 1 in hepatic acute phase response

1 reference

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14 September 2017

Redox regulation of DNA repair: implications for human health and cancer therapeutic development

1 reference

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14 September 2017

Genome-wide analysis and proteomic studies reveal APE1/Ref-1 multifunctional role in mammalian cells.

1 reference

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14 September 2017

The many functions of APE1/Ref-1: not only a DNA repair enzyme

1 reference

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14 September 2017

Transcriptional regulatory functions of mammalian AP-endonuclease (APE1/Ref-1), an essential multifunctional protein

1 reference

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14 September 2017

Going ape as an approach to cancer therapeutics

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14 September 2017

Role of the multifunctional DNA repair and redox signaling protein Ape1/Ref-1 in cancer and endothelial cells: small-molecule inhibition of the redox function of Ape1

1 reference

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Knockdown of the DNA repair and redox signaling protein Ape1/Ref-1 blocks ovarian cancer cell and tumor growth

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The DNA base excision repair protein Ape1/Ref-1 as a therapeutic and chemopreventive target

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Identification and characterization of mitochondrial abasic (AP)-endonuclease in mammalian cells

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Recent updates on the role of chemotherapy in pancreatic cancer

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Isolation of a small molecule inhibitor of DNA base excision repair.

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The intracellular localization of APE1/Ref-1: more than a passive phenomenon?

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Effects of gemcitabine on APE/ref-1 endonuclease activity in pancreatic cancer cells, and the therapeutic potential of antisense oligonucleotides.

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14 September 2017

Therapeutic impact of methoxyamine: blocking repair of abasic sites in the base excision repair pathway.

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Human apurinic endonuclease 1 (APE1) expression and prognostic significance in osteosarcoma: enhanced sensitivity of osteosarcoma to DNA damaging agents using silencing RNA APE1 expression inhibition

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Differential contribution of inhibitory phosphorylation of CDC2 and CDK2 for unperturbed cell cycle control and DNA integrity checkpoints.

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Influence of hypoxia and neoangiogenesis on the growth of pancreatic cancer

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14 September 2017

Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A

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14 September 2017

Going APE over ref-1.

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Identification of novel purine and pyrimidine cyclin-dependent kinase inhibitors with distinct molecular interactions and tumor cell growth inhibition profiles

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Creation of a fully functional human chimeric DNA repair protein. Combining O6-methylguanine DNA methyltransferase (MGMT) and AP endonuclease (APE/redox effector factor 1 (Ref 1)) DNA repair proteins

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12 December 2020

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The apurinic/apyrimidinic endonuclease (APE/ref-1) DNA repair enzyme is elevated in premalignant and malignant cervical cancer

1 reference

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based on heuristic

inferred from PubMed ID database lookup

O6-benzylguanine in humans: metabolic, pharmacokinetic, and pharmacodynamic findings

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Enhanced ADP-ribosylation and its diminution by lipoamide after ischemia-reperfusion in perfused rat heart

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Alterations in the expression of the DNA repair/redox enzyme APE/ref-1 in epithelial ovarian cancers

1 reference

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Identifiers

10.3109/07357907.2010.512816

1 reference

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15 February 2020

PMC publication ID

1 reference

Europe PubMed Central

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15 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

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15 February 2020

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