l-Carnitine. A preliminary review of its pharmacokinetics, and its therapeutic use in ischaemic cardiac disease and primary and secondary carnitine deficiencies in relationship to its role in fatty acid metabolism (Q39669492)

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scientific article published on July 1987

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English	l-Carnitine. A preliminary review of its pharmacokinetics, and its therapeutic use in ischaemic cardiac disease and primary and secondary carnitine deficiencies in relationship to its role in fatty acid metabolism	scientific article published on July 1987

Statements

scholarly article

1 reference

Europe PubMed Central

13 September 2017

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Europe PubMed Central

l-Carnitine. A preliminary review of its pharmacokinetics, and its therapeutic use in ischaemic cardiac disease and primary and secondary carnitine deficiencies in relationship to its role in fatty acid metabolism (English)

1 reference

Europe PubMed Central

13 September 2017

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inferred from title

pharmacokinetics

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2

object named as

R N Brogden

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Europe PubMed Central

13 September 2017

author name string

K L Goa

1

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Europe PubMed Central

13 September 2017

publication date

1 July 1987

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Europe PubMed Central

13 September 2017

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Europe PubMed Central

13 September 2017

34

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Europe PubMed Central

13 September 2017

1

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Europe PubMed Central

13 September 2017

1-24

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Europe PubMed Central

13 September 2017

https://scigraph.springernature.com/pub.10.2165/00003495-198734010-00001

0 references

Quantitative assessment of carnitine loss during hemodialysis and hemofiltration

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

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inferred from PubMed ID database lookup

Systemic carnitine deficiency simulating recurrent Reye syndrome.

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

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inferred from PubMed ID database lookup

An improved and simplified radioisotopic assay for the determination of free and esterified carnitine

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

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Nonketotic hypoglycemia: an early indicator of systemic carnitine deficiency.

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https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

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[Clinical, morphological and biochemical studies on muscle carnitine deficiency (author's transl)]

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https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

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Experiences with L-carnitine in the post-stress phase

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Carnitine in human nutrition

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

based on heuristic

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Carnitine deficiency presenting as familial cardiomyopathy: a treatable defect in carnitine transport

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Carnitine deficiency in premature infants receiving total parenteral nutrition: effect of L-carnitine supplementation

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of carnitine on serum HDL-cholesterol: report of two cases

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Systemic carnitine deficiency. Report of a fatal case with multisystemic manifestations

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

based on heuristic

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Absorption of D- and L-carnitine by the intestine and kidney tubule in the rat.

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https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

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Effects of L-carnitine on exercise tolerance in patients with stable angina pectoris

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https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

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Carnitine metabolism and deficiency syndromes

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https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

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Evidence for autosomal recessive inheritance in systemic carnitine deficiency

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

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Ameliorating effects of carnitine and its precursors on alcohol-induced fatty liver

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https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

based on heuristic

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Perturbation of serum carnitine levels in human adults by chronic renal disease and dialysis therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Carnitine balance and effects of intravenous L-carnitine in two patients receiving long-term total parenteral nutrition

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

based on heuristic

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Lipid metabolism in parenterally alimented neonates: carnitine blood concentrations and fat utilization

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

based on heuristic

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Potential role of carnitine in patients with renal insufficiency

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A hereditary case of lipid storage myopathy with carnitine deficiency. Ultrastructural observation of muscle tissue in parents

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

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inferred from PubMed ID database lookup

Carnitine transport in human intestinal biopsy specimens. Demonstration of an active transport system.

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

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Propionylcarnitine excretion in propionic and methylmalonic acidurias: a cause of carnitine deficiency.

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Improved pacing tolerance of the ischemic human myocardium after administration of carnitine

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Encephalopathy and fatal myopathy in two siblings. Their association with partial deficiency of muscle carnitine.

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

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inferred from PubMed ID database lookup

[Plasma l-carnitine in patients with chronic hemodialysis. II. Pharmacokinetics of l-carnitine and its replacement therapy in these patients]

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced lipid utilization in infants receiving oral L-carnitine during long-term parenteral nutrition

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[A case of myopathy with carnitine deficiency]

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of carnitine administration in patients with chronic renal failure undergoing periodic dialysis, evaluated by computerized electromyography

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Favorable effects of L-carnitine treatment on hypertriglyceridemia in hemodialysis patients: decisive role of low levels of high-density lipoprotein-cholesterol

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

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Myasthenia due to carnitine treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

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Familial carnitine deficiency. A fatal case and subclinical state in a sister

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

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Carnitine Deficiency of Human Skeletal Muscle with Associated Lipid Storage Myopathy: A New Syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

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L-carnitine enhances excretion of propionyl coenzyme A as propionylcarnitine in propionic acidemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

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L-carnitine and haemodialysis: double blind study on muscle function and metabolism and peripheral nerve function

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

based on heuristic

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Plasma carnitine levels during intravenous feeding of the neonate

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Carnitine plasma levels during total parenteral nutrition

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

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inferred from PubMed ID database lookup

Blood levels of total carnitine and lipid utilization with and without carnitine supplementation in newborn infants

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

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L-carnitine for methylmalonicaciduria

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

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High dose of L-carnitine increases platelet aggregation and plasma triglyceride levels in uremic patients on hemodialysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

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Correlation between increased serum and tissue L-carnitine levels and improved muscle symptoms in hemodialyzed patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Systemic carnitine deficiency: Clinical, biochemical, and morphological cure with L-carnitine

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An X-linked mitochondrial disease affecting cardiac muscle, skeletal muscle and neutrophil leucocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

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Metabolism, turnover time, half life, body pool of carnitine-14C in normal, alloxan diabetic and insulin treated rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autosomal recessive lipid storage myopathy (probable carnitine deficiency)

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Successful treatment of familial idiopathic lipid storage myopathy with L-carnitine and modified lipid diet.

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Systemic carnitine deficiency presenting as familial endocardial fibroelastosis: a treatable cardiomyopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Carnitine in the perinatal metabolism of lipids. I. Relationship between maternal and fetal plasma levels of carnitine and acylcarnitines

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics of l-carnitine in man following intravenous infusion of dl-carnitine

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Carnitine levels in skeletal muscle of malnourished patients before and after total parenteral nutrition

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fatal Reye-like syndrome associated with valproic acid

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reye-like syndrome associated with valproic acid therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetic compartmental analysis of carnitine metabolism in the human carnitine deficiency syndromes. Evidence for alterations in tissue carnitine transport

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolic response to carnitine in methylmalonic aciduria. An effective strategy for elimination of propionyl groups

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of carnitine in fatty acid metabolism of normal and ischemic myocardium

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

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Free and total carnitine in human serum after oral ingestion of L-carnitine.

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

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Carnitine deficiency with valproate therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

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Carnitine prevention of adriamycin toxicity in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of carnitine on lipid metabolism in the neonate. II. Carnitine addition to lipid infusion during prolonged total parenteral nutrition

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transfer and metabolism of carnitine and carnitine esters in the in vitro perfused human placenta

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

based on heuristic

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Systemic carnitine deficiency exacerbated by a strict vegetarian diet

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Successful carnitine treatment in two siblings having lipid storage myopathy with hypertrophic cardiomyopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antagonism of doxorubicin cardiotoxicity by carnitine is specific of the L-diasteroisomer

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

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Effects of L-carnitine loading on the aerobic and anaerobic performance of endurance athletes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

based on heuristic

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Serum and urinary carnitine and organic acids in Reye syndrome and Reye-like syndrome.

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

based on heuristic

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Biochemical derangements in ischemic myocardium: the role of carnitine

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Urinary carnitine excretion in surgical patients on total parenteral nutrition

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of carnitine administration, fasting, and exercise on urinary carnitine excretion in man.

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Familial cardiomyopathy caused by carnitine deficiency

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Primary systemic carnitine deficiency. II. Renal handling of carnitine

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Myasthenia-like syndrome after D,L- but not L-carnitine

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[Congenital myopathy with lipid and glycogen overload of muscle fiber and partial deficit of carnitine]

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduction of cardiac toxicity of anthracyclines by L-carnitine: preliminary overview of clinical data

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Carnitine and neonatal lipid metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Carnitine deficiency of skeletal muscle: report of a treated case

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of fasting on free and esterified carnitine levels in human serum and urine: Correlation with serum levels of free fatty acids and β-hydroxybutyrate

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MYOCARDIAL CARNITINE DEFICIENCY IN ACUTE MYOCARDIAL INFARCTION

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased tissue carnitine concentrations in newborn infants receiving total parenteral nutrition

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Carnitine metabolism and its application in parenteral nutrition

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Parenteral nutrition: current status and concepts

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protective effect of L-carnitine on cardiac metabolic damage induced by doxorubicin in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Postheparin plasma lipases and carnitine in infants during parenteral nutrition

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

L-Carnitine dissimilation in the gastrointestinal tract of the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Carnitine and left ventricular function in haemodialysis patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Carnitine deficiency and hyperammonemia associated with valproic acid therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A case history of myopathic carnitine deficiency benefited by glucocorticoids and L-carnitine supplementation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasma carnitine levels during total parenteral nutrition of adult surgical patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Muscle carnitine deficiency. Association with lipid myopathy, vacuolar neuropathy, and vacuolated leukocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypoglycemia, hepatic dysfunction, muscle weakness, cardiomyopathy, free carnitine deficiency and long-chain acylcarnitine excess responsive to medium chain triglyceride diet.

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of L-carnitine in the pathogenesis of cardiomegaly in patients with chronic hemodialysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasma lipoproteins, liver function and glucose metabolism in haemodialysis patients: lack of effect of L-carnitine supplementation

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endocrine-metabolic effects of l-carnitine in patients on regular dialysis treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

L-carnitine treatment in glutaric aciduria type I.

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Possible carnitine deficiency in parenterally alimented newborn infants

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of aging on lipid and carnitine metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tissue carnitine in Reye syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Carnitine deficiency in haemodialysed patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hereditary carnitine deficiency of muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/3308409

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.2165/00003495-198734010-00001

1 reference

Europe PubMed Central

13 September 2017

Dimensions Publication ID

0 references

1 reference

Europe PubMed Central

13 September 2017

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