Biodistribution, pharmacokinetics, and nuclear imaging studies of 111In-labeled rGel/BLyS fusion toxin in SCID mice bearing B cell lymphoma (Q39670991)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20686856%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

title

Biodistribution, pharmacokinetics, and nuclear imaging studies of 111In-labeled rGel/BLyS fusion toxin in SCID mice bearing B cell lymphoma (English)

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9 February 2020

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single-photon emission computed tomography

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17 June 2024

6

Dong Liang

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17 June 2024

author name string

Xiaoxia Wen

1

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9 February 2020

Mi-Ae Lyu

2

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9 February 2020

Rui Zhang

3

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9 February 2020

Wei Lu

4

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9 February 2020

Qian Huang

5

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9 February 2020

Chun Li

8

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9 February 2020

Michael G. Rosenblum

7

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17 June 2024

language of work or name

English

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National Center for Biotechnology Information

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17 June 2024

publication date

1 August 2011

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full work available at URL

9 February 2020

https://europepmc.org/articles/pmc6279425?pdf=render

file format

Portable Document Format

online access status

open access

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https://europepmc.org/articles/PMC6279425

17 June 2024

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https://europepmc.org/articles/PMC6279425?pdf=render

17 June 2024

file format

Portable Document Format

online access status

open access

content deliverer

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20686856

https://doi.org/10.1007/s11307-010-0391-0

17 June 2024

online access status

open access

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Molecular Imaging and Biology

17 June 2024

published in

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9 February 2020

volume

13

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9 February 2020

issue

4

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9 February 2020

page(s)

721-729

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Attenuation of apoptosis underlies B lymphocyte stimulator enhancement of humoral immune response

9 February 2020

cites work

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BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator

21 January 2018

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Identification and characterization of a novel cytokine, THANK, a TNF homologue that activates apoptosis, nuclear factor-kappaB, and c-Jun NH2-terminal kinase

21 January 2018

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BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth

21 January 2018

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Characterization of a new member of the TNF family expressed on antigen presenting cells

21 January 2018

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BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF

21 January 2018

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NF-AT activation induced by a CAML-interacting member of the tumor necrosis factor receptor superfamily

21 January 2018

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BAFF binds to the tumor necrosis factor receptor-like molecule B cell maturation antigen and is important for maintaining the peripheral B cell population

21 January 2018

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TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease

21 January 2018

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Requirements for the inactivation of ribosomes by gelonin

21 January 2018

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In vitro and in vivo studies of a VEGF121/rGelonin chimeric fusion toxin targeting the neovasculature of solid tumors

21 January 2018

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The rGel/BLyS fusion toxin specifically targets malignant B cells expressing the BLyS receptors BAFF-R, TACI, and BCMA.

21 January 2018

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The growth factor fusion construct containing B-lymphocyte stimulator (BLyS) and the toxin rGel induces apoptosis specifically in BAFF-R-positive CLL cells.

21 January 2018

1 reference

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The use of radiolabeled compounds for ADME studies in discovery and exploratory development

21 January 2018

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Structural basis of BLyS receptor recognition

21 January 2018

1 reference

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BLyS and BLyS receptor expression in non-Hodgkin's lymphoma

21 January 2018

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12 December 2020

RNA present in post-ribosomal supernatants makes ribosomes susceptible to inactivation by gelonin and alpha-sarcin.

1 reference

12 December 2020

Rapid and specific targeting of 125I-labeled B lymphocyte stimulator to lymphoid tissues and B cell tumors in mice

1 reference

12 December 2020

TALL-1 is a novel member of the TNF family that is down-regulated by mitogens

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12 December 2020

Gelonin, a new inhibitor of protein synthesis, nontoxic to intact cells. Isolation, characterization, and preparation of cytotoxic complexes with concanavalin A

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12 December 2020

Pharmacokinetics and biodistribution of engineered single-chain antibody constructs of MAb CC49 in colon carcinoma xenografts

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12 December 2020

A new gene, BCM, on chromosome 16 is fused to the interleukin 2 gene by a t(4;16)(q26;p13) translocation in a malignant T cell lymphoma

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12 December 2020

Bone marrow purging studies in acute myelogenous leukemia using the recombinant anti-CD33 immunotoxin HuM195/rGel

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12 December 2020

Multimodality molecular imaging of glioblastoma growth inhibition with vasculature-targeting fusion toxin VEGF121/rGel.

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12 December 2020

Recombinant immunotoxins directed against the c-erb-2/HER2/neu oncogene product: in vitro cytotoxicity, pharmacokinetics, and in vivo efficacy studies in xenograft models

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12 December 2020

Design, expression, purification, and characterization, in vitro and in vivo, of an antimelanoma single-chain Fv antibody fused to the toxin gelonin

1 reference

12 December 2020

Localization and imaging with radioiodine-labeled monoclonal antibodies in a xenogeneic tumor model for human B-cell lymphoma

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12 December 2020

A specific and potent immunotoxin composed of antibody ZME-018 and the plant toxin gelonin.

1 reference

12 December 2020

The rGel/BLyS fusion toxin inhibits diffuse large B-cell lymphoma growth in vitro and in vivo

1 reference

12 December 2020

10.1007/S11307-010-0391-0

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20686856%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

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9 February 2020

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