The case for PfEMP1-based vaccines to protect pregnant women against Plasmodium falciparum malaria (Q39698908)

14 September 2017

The case for PfEMP1-based vaccines to protect pregnant women against Plasmodium falciparum malaria (English)

1 reference

pregnancy-associated malaria

14 September 2017

Plasmodium falciparum

0 references

malaria

0 references

1 reference

1 reference

1 reference

1 reference

Lars Hviid

1

0 references

publication date

1 October 2011

1 reference

Expert Review of Vaccines

14 September 2017

1 reference

14 September 2017

10

1 reference

14 September 2017

10

1 reference

14 September 2017

1405-1414

1 reference

Quantifying the number of pregnancies at risk of malaria in 2007: a demographic study

14 September 2017

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Epidemiology and burden of malaria in pregnancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Effects of Plasmodium vivax malaria in pregnancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Adverse pregnancy outcomes in an area where multidrug-resistant plasmodium vivax and Plasmodium falciparum infections are endemic

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

A large focus of naturally acquired Plasmodium knowlesi infections in human beings

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Plasmodium knowlesi malaria in humans is widely distributed and potentially life threatening

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Proteomic studies of Plasmodium knowlesi SICA variant antigens demonstrate their relationship with P. falciparum EMP1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Naturally acquired immunity to Plasmodium falciparum malaria in Africa

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

The immuno-epidemiology of pregnancy-associated Plasmodium falciparum malaria: a variant surface antigen-specific perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Selective accumulation of mature asexual stages of Plasmodium falciparum-infected erythrocytes in the placenta

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Adherence of Plasmodium falciparum to chondroitin sulfate A in the human placenta

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Selective upregulation of a single distinctly structured var gene in chondroitin sulphate A-adhering Plasmodium falciparum involved in pregnancy-associated malaria

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Evidence for the involvement of VAR2CSA in pregnancy-associated malaria

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Pregnancy-associated malaria and the prospects for syndrome-specific antimalaria vaccines

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Chondroitin-4-sulphate (proteoglycan), a receptor for Plasmodium falciparum-infected erythrocyte adherence on brain microvascular endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Chondroitin sulfate A is a cell surface receptor for Plasmodium falciparum-infected erythrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Role of nonimmune IgG bound to PfEMP1 in placental malaria.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Adhesion of Plasmodium falciparum-infected erythrocytes to hyaluronic acid in placental malaria

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Nonspecific immunoglobulin M binding and chondroitin sulfate A binding are linked phenotypes of Plasmodium falciparum isolates implicated in malaria during pregnancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Chondroitin sulfate proteoglycan but not hyaluronic acid is the receptor for the adherence of Plasmodium falciparum-infected erythrocytes in human placenta, and infected red blood cell adherence up-regulates the receptor expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Plasmodium falciparum isolates from infected pregnant women and children are associated with distinct adhesive and antigenic properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Plasmodium falciparum rosette formation is uncommon in isolates from pregnant women

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Chondroitin sulfate A-adhering Plasmodium falciparum-infected erythrocytes express functionally important antibody epitopes shared by multiple variants

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Transcription of var genes other than var2csa in Plasmodium falciparum parasites infecting Mozambican pregnant women

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Maternal antibodies block malaria

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Acquisition and decay of antibodies to pregnancy-associated variant antigens on the surface of Plasmodium falciparum-infected erythrocytes that protect against placental parasitemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Antibodies that inhibit Plasmodium falciparum adhesion to chondroitin sulfate A are associated with increased birth weight and the gestational age of newborns

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Variant surface antigen-specific IgG and protection against clinical consequences of pregnancy-associated Plasmodium falciparum malaria

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Identification of a strain-specific malarial antigen exposed on the surface of Plasmodium falciparum-infected erythrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Cloning the P. falciparum gene encoding PfEMP1, a malarial variant antigen and adherence receptor on the surface of parasitized human erythrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Switches in expression of Plasmodium falciparum var genes correlate with changes in antigenic and cytoadherent phenotypes of infected erythrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

The large diverse gene family var encodes proteins involved in cytoadherence and antigenic variation of plasmodium falciparum-infected erythrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

High level of var2csa transcription by Plasmodium falciparum isolated from the placenta

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Transcribed var genes associated with placental malaria in Malawian women.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Six genes are preferentially transcribed by the circulating and sequestered forms of Plasmodium falciparum parasites that infect pregnant women

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Genome sequence of the human malaria parasite Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

VAR2CSA expression on the surface of placenta-derived Plasmodium falciparum-infected erythrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Plasmodium falciparum domain mediating adhesion to chondroitin sulfate A: a receptor for human placental infection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

The adhesion of Plasmodium falciparum-infected erythrocytes to chondroitin sulfate A is mediated by P. falciparum erythrocyte membrane protein 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Plasmodium falciparum: cloned and expressed CIDR domains of PfEMP1 bind to chondroitin sulfate A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Variants of Plasmodium falciparum erythrocyte membrane protein 1 expressed by different placental parasites are closely related and adhere to chondroitin sulfate A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Chondroitin sulphate A (CSA)-binding of single recombinant Duffy-binding-like domains is not restricted to Plasmodium falciparum Erythrocyte Membrane Protein 1 expressed by CSA-binding parasites

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Full-length recombinant Plasmodium falciparum VAR2CSA binds specifically to CSPG and induces potent parasite adhesion-blocking antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Full-length extracellular region of the var2CSA variant of PfEMP1 is required for specific, high-affinity binding to CSA

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

A single member of the Plasmodium falciparum var multigene family determines cytoadhesion to the placental receptor chondroitin sulphate A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

VAR2CSA is the principal ligand for chondroitin sulfate A in two allogeneic isolates of Plasmodium falciparum.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Disruption of var2csa gene impairs placental malaria associated adhesion phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Human pregnancy-associated malaria-specific B cells target polymorphic, conformational epitopes in VAR2CSA

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

The NTS-DBL2X region of VAR2CSA induces cross-reactive antibodies that inhibit adhesion of several Plasmodium falciparum isolates to chondroitin sulfate A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

The chondroitin sulfate A-binding site of the VAR2CSA protein involves multiple N-terminal domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Var2CSA minimal CSA binding region is located within the N-terminal region

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

The Structure of a Chondroitin Sulfate-binding Domain Important in Placental Malaria

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Structure of the DBL3x domain of pregnancy-associated malaria protein VAR2CSA complexed with chondroitin sulfate A

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Subdomain 3 of Plasmodium falciparum VAR2CSA DBL3x is identified as a minimal chondroitin sulfate A-binding region

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Structural basis for the adherence of Plasmodium falciparum-infected erythrocytes to chondroitin 4-sulfate and design of novel photoactivable reagents for the identification of parasite adhesive proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Mass spectrometric analysis of Plasmodium falciparum erythrocyte membrane protein-1 variants expressed by placental malaria parasites

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

The distinct proteome of placental malaria parasites

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Analysis of the Plasmodium falciparum proteome by high-accuracy mass spectrometry.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Plasmodium falciparum transcriptome analysis reveals pregnancy malaria associated gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Dynamics of anti-VAR2CSA immunoglobulin G response in a cohort of senegalese pregnant women.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Cytoadhesion of Plasmodium falciparum ring-stage-infected erythrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Effect of pregnancy on exposure to malaria mosquitoes

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Short-range attractiveness of pregnant women to Anopheles gambiae mosquitoes

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

There is a bias against type 1 (inflammatory) cytokine expression and function in pregnancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Influence of the timing of malaria infection during pregnancy on birth weight and on maternal anemia in Benin

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

The sick placenta-the role of malaria.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Late recrudescence of Plasmodium falciparum malaria in a pregnant woman: a case report

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

[Pregnancy associated Plasmodium falciparum malaria discovered fortuitously: report of two cases].

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Development of vaccines to prevent malaria in pregnant women: WHO MALVAC meeting report

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Rapid spontaneous postpartum clearance of Plasmodium falciparum parasitaemia in African women

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Expression of variant surface antigens by Plasmodium falciparum parasites in the peripheral blood of clinically immune pregnant women indicates ongoing placental infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Spontaneous postpartum clearance of Plasmodium falciparum parasitemia in pregnant women, Benin

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Plasmodium falciparum: PCR detection and genotyping of isolates from peripheral, placental, and cord blood of pregnant Malawian women and their infants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Variable adhesion abilities and overlapping antigenic properties in placental Plasmodium falciparum isolates

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Maternal vitamin A supplementation and immunity to malaria in pregnancy in Ghanaian primigravids

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Using an improved phagocytosis assay to evaluate the effect of HIV on specific antibodies to pregnancy-associated malaria

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

The effect of intermittent preventive treatment during pregnancy on malarial antibodies depends on HIV status and is not associated with poor delivery outcomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Rapid acquisition of isolate-specific antibodies to chondroitin sulfate A-adherent plasmodium falciparum isolates in Ghanaian primigravidae

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Induction of adhesion-inhibitory antibodies against placental Plasmodium falciparum parasites by using single domains of VAR2CSA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

High efficacy of anti DBL4ɛ-VAR2CSA antibodies in inhibition of CSA-binding Plasmodium falciparum-infected erythrocytes from pregnant women

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Evasion of immunity to Plasmodium falciparum malaria by IgM masking of protective IgG epitopes in infected erythrocyte surface-exposed PfEMP1

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Gravidity-dependent production of antibodies that inhibit binding of Plasmodium falciparum-infected erythrocytes to placental chondroitin sulfate proteoglycan during pregnancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Simultaneous transcription of duplicated var2csa gene copies in individual Plasmodium falciparum parasites

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Multiple var2csa-type PfEMP1 genes located at different chromosomal loci occur in many Plasmodium falciparum isolates

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Positive selection of Plasmodium falciparum parasites with multiple var2csa-type PfEMP1 genes during the course of infection in pregnant women

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Plasmodium falciparum erythrocyte membrane protein 1 diversity in seven genomes--divide and conquer

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Global genetic diversity and evolution of var genes associated with placental and severe childhood malaria

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Epitope mapping and topographic analysis of VAR2CSA DBL3X involved in P. falciparum placental sequestration

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Evaluation of the antigenic diversity of placenta-binding Plasmodium falciparum variants and the antibody repertoire among pregnant women

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Cross-reactive surface epitopes on chondroitin sulfate A-adherent Plasmodium falciparum-infected erythrocytes are associated with transcription of var2csa

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Structural insight into epitopes in the pregnancy-associated malaria protein VAR2CSA

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Human monoclonal IgG selection of Plasmodium falciparum for the expression of placental malaria-specific variant surface antigens

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Immunization with VAR2CSA-DBL5 recombinant protein elicits broadly cross-reactive antibodies to placental Plasmodium falciparum-infected erythrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Strain-transcendent immune response to recombinant Var2CSA DBL5-ε domain block P. falciparum adhesion to placenta-derived BeWo cells under flow conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Insight into antigenic diversity of VAR2CSA-DBL5ε domain from multiple Plasmodium falciparum placental isolates

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Antibodies to a full-length VAR2CSA immunogen are broadly strain-transcendent but do not cross-inhibit different placental-type parasite isolates

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

Malaria in pregnancy: pathogenesis and immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2FERV.11.113

21 January 2018

Identifiers

DOI

10.1586/ERV.11.113

1 reference

14 September 2017

1 reference

PubMed ID

21988306