Novel antileukemic compound ingenol 3-angelate inhibits T cell apoptosis by activating protein kinase Ctheta (Q39703538)

14 September 2017

Novel antileukemic compound ingenol 3-angelate inhibits T cell apoptosis by activating protein kinase Ctheta (English)

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14 September 2017

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Wing-Yiu Lee

1

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Janet M Lord

object named as

Janet M Lord

6

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author name string

Peter Hampson

2

1 reference

14 September 2017

Lydia Coulthard

3

1 reference

14 September 2017

Farrah Ali

4

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14 September 2017

Mike Salmon

5

1 reference

14 September 2017

Dagmar Scheel-Toellner

7

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14 September 2017

language of work or name

English

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publication date

14 May 2010

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Journal of Biological Chemistry

14 September 2017

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14 September 2017

285

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14 September 2017

31

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14 September 2017

23889-23898

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Protein kinase C-theta-mediated signals enhance CD4+ T cell survival by up-regulating Bcl-xL

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911273

Critical role of novel Thr-219 autophosphorylation for the cellular function of PKCtheta in T lymphocytes.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911273

Central memory self/tumor-reactive CD8+ T cells confer superior antitumor immunity compared with effector memory T cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911273

Constitutive association of the proapoptotic protein Bim with Bcl-2-related proteins on mitochondria in T cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911273

Characterization of the interaction of ingenol 3-angelate with protein kinase C.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911273

Central memory and effector memory T cell subsets: function, generation, and maintenance

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911273

CD3/CD28 costimulation-induced NF-kappaB activation is mediated by recruitment of protein kinase C-theta, Bcl10, and IkappaB kinase beta to the immunological synapse through CARMA1

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911273

Molecular mechanisms of activated T cell death in vivo

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911273

Protein kinase C: structural and spatial regulation by phosphorylation, cofactors, and macromolecular interactions

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911273

Proliferation, cell cycle and apoptosis in cancer

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911273

NF-kappa B activation induced by T cell receptor/CD28 costimulation is mediated by protein kinase C-theta

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911273

Three-dimensional segregation of supramolecular activation clusters in T cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911273

Isoenzymes of protein kinase C: differential involvement in apoptosis and pathogenesis

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911273

Selective modulation of protein kinase C-theta during T-cell activation

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911273

Molecular cloning and characterization of PKC theta, a novel member of the protein kinase C (PKC) gene family expressed predominantly in hematopoietic cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911273

Biochemical and biological characterization of lymphocyte regulatory molecules. V. Identification of an interleukin 2-producing human leukemia T cell line

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911273

Differential regulation of nuclear and mitochondrial Bcl-2 in T cell apoptosis.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911273

Neutrophils are a key component of the antitumor efficacy of topical chemotherapy with ingenol-3-angelate

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911273

Protein kinase C-theta isoenzyme selective stimulation of the transcription factor complex AP-1 in T lymphocytes

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911273

Bim-mediated deletion of antigen-specific CD8 T cells in patients unable to control HBV infection

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911273

IL-2 addiction: withdrawal of growth factor activates a suicide program in dependent T cells.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911273

A new member of the protein kinase C family, nPKC theta, predominantly expressed in skeletal muscle

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911273

Home treatment of basal cell carcinoma

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911273

Targeting the protein kinase C family: are we there yet?

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911273

Protein kinase C-theta is an early survival factor required for differentiation of effector CD8+ T cells.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911273

PEP005, a selective small-molecule activator of protein kinase C, has potent antileukemic activity mediated via the delta isoform of PKC.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911273

PKC-δ is an apoptotic lamin kinase

20 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M109.041962

Apoptosis by IL-2 deprivation in human CD8+ T cell blasts predominates over death receptor ligation, requires Bim expression and is associated with Mcl-1 loss

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M109.041962

PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M109.041962

CD4+ and CD8+ T cell survival is regulated differentially by protein kinase Ctheta, c-Rel, and protein kinase B

21 January 2018

1 reference

12 December 2020

T cells remaining after intensive chemotherapy for acute myelogenous leukemia show a broad cytokine release profile including high levels of interferon-gamma that can be further increased by a novel protein kinase C agonist PEP005

1 reference

12 December 2020

T cell fitness determined by signal strength

1 reference

12 December 2020

Co-induction of lymphokine synthesis by the antineoplastic bryostatins

1 reference

12 December 2020

HOME TREATMENT OF SKIN CANCER AND SOLAR KERATOSES

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M109.041962

1 reference

14 September 2017

1 reference

14 September 2017

PubMed publication ID

20472553

1 reference