Benzoxaboroles: a new class of potential drugs for human African trypanosomiasis (Q39715299)

14 September 2017

title

Benzoxaboroles: a new class of potential drugs for human African trypanosomiasis (English)

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14 September 2017

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African trypanosomiasis

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author name string

Robert T Jacobs

1

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Jacob J Plattner

2

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Bakela Nare

3

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Stephen A Wring

4

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Daitao Chen

5

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Yvonne Freund

6

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Eric G Gaukel

7

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Matthew D Orr

8

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Joe B Perales

9

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Matthew Jenks

10

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Robert A Noe

11

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Jessica M Sligar

12

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Yong-Kang Zhang

13

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Cyrus J Bacchi

14

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Nigel Yarlett

15

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Robert Don

16

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publication date

1 August 2011

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Future Medicinal Chemistry

14 September 2017

published in

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volume

3

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issue

10

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14 September 2017

page(s)

1259-1278

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Eliminating human African trypanosomiasis: where do we stand and what comes next?

14 September 2017

cites work

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21 January 2018

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21 January 2018

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Nifurtimox-eflornithine combination therapy for second-stage African Trypanosoma brucei gambiense trypanosomiasis: a multicentre, randomised, phase III, non-inferiority trial

21 January 2018

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NECT is next: implementing the new drug combination therapy for Trypanosoma brucei gambiense sleeping sickness

21 January 2018

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Inhibition of serine proteases by arylboronic acids

21 January 2018

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Boron therapeutics on the horizon

21 January 2018

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Discovery of a new boron-containing antifungal agent, 5-fluoro-1,3-dihydro-1-hydroxy-2,1- benzoxaborole (AN2690), for the potential treatment of onychomycosis

21 January 2018

1 reference

An antifungal agent inhibits an aminoacyl-tRNA synthetase by trapping tRNA in the editing site

21 January 2018

1 reference

Discovery and structure-activity study of a novel benzoxaborole anti-inflammatory agent (AN2728) for the potential topical treatment of psoriasis and atopic dermatitis

21 January 2018

1 reference

Synthesis and structure-activity relationships of novel benzoxaboroles as a new class of antimalarial agents

21 January 2018

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Synthesis of new acylsulfamoyl benzoxaboroles as potent inhibitors of HCV NS3 protease

21 January 2018

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Synthesis and biological evaluations of P4-benzoxaborole-substituted macrocyclic inhibitors of HCV NS3 protease

21 January 2018

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Discovery of novel orally bioavailable oxaborole 6-carboxamides that demonstrate cure in a murine model of late-stage central nervous system african trypanosomiasis

21 January 2018

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Discovery of novel benzoxaborole-based potent antitrypanosomal agents

21 January 2018

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Drug-like properties and the causes of poor solubility and poor permeability

21 January 2018

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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

21 January 2018

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Steady-state brain concentrations of antihistamines in rats: interplay of membrane permeability, P-glycoprotein efflux and plasma protein binding

21 January 2018

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In vitro absorption and secretory quotients: practical criteria derived from a study of 331 compounds to assess for the impact of P-glycoprotein-mediated efflux on drug candidates.

21 January 2018

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In vitro drug sensitivity of Trypanosoma gambiense isolates

21 January 2018

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Comparison of the in vitro drug sensitivity of Trypanosoma brucei gambiense strains from West and Central Africa isolated in the periods 1960-1995 and 1999-2004.

21 January 2018

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SCYX-7158, an orally-active benzoxaborole for the treatment of stage 2 human African trypanosomiasis

21 January 2018

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Boronic acids in medicinal chemistry: anticancer, antibacterial and antiviral applications

21 January 2018

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21 January 2018

Identifiers

DOI

10.4155/FMC.11.80

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14 September 2017

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