A chicken-or-egg conundrum in apoptosis: which comes first? Ceramide or PKCdelta? (Q39737705)

14 September 2017

A chicken-or-egg conundrum in apoptosis: which comes first? Ceramide or PKCdelta? (English)

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14 September 2017

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2

Sarah Spiegel

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14 September 2017

Steven Grant

1

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PMCID

150920

14 September 2017

language of work or name

English

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publication date

1 March 2002

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14 September 2017

3

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Journal of Clinical Investigation

inferred from page(s)

published in

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14 September 2017

109

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14 September 2017

6

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14 September 2017

717-719

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Protein kinase Cdelta amplifies ceramide formation via mitochondrial signaling in prostate cancer cells

14 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150920

Smac is required for cytochrome c-induced apoptosis in prostate cancer LNCaP cells.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150920

BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150920

Subtype-specific translocation of the delta subtype of protein kinase C and its activation by tyrosine phosphorylation induced by ceramide in HeLa cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150920

Structural basis of IAP recognition by Smac/DIABLO

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150920

Serine palmitoyltransferase regulates de novo ceramide generation during etoposide-induced apoptosis

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150920

Ceramide in the eukaryotic stress response

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150920

Protein kinase Cdelta targets mitochondria, alters mitochondrial membrane potential, and induces apoptosis in normal and neoplastic keratinocytes when overexpressed by an adenoviral vector

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150920

Molecular characterization of mitochondrial apoptosis-inducing factor

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150920

Ceramide synthase mediates daunorubicin-induced apoptosis: an alternative mechanism for generating death signals

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150920

PKCdelta is required for mitochondrial-dependent apoptosis in salivary epithelial cells.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150920

Increased activity of the protein kinase C-delta holoenzyme in the cytoplasmic particulate fraction precedes the activation of caspases in polyomavirus-transformed pyF111 rat fibroblasts exposed to calphostin C or topoisomerase-II inhibitors.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150920

Ordering of ceramide formation, caspase activation, and mitochondrial changes during CD95- and DNA damage-induced apoptosis

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150920

Ceramide in apoptosis--does it really matter?

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150920

Ceramide enables fas to cap and kill.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150920

Involvement of protein kinase C-delta in DNA damage-induced apoptosis

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150920

Distinct caspase cascades are initiated in receptor-mediated and chemical-induced apoptosis.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150920

12-O-tetradecanoylphorbol-13-acetate-induced apoptosis in LNCaP cells is mediated through ceramide synthase.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=150920

20 August 2018

Ceramide and apoptosis

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12 December 2020

Involvement of sphingosine in mitochondria-dependent Fas-induced apoptosis of type II Jurkat T cells

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12 December 2020

Mitochondrial translocation of protein kinase C delta in phorbol ester-induced cytochrome c release and apoptosis

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12 December 2020

Ceramide-induced translocation of protein kinase C-delta and -epsilon to the cytosol. Implications in apoptosis

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12 December 2020

Selective ceramide binding to protein kinase C-alpha and -delta isoenzymes in renal mesangial cells

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12 December 2020

Identifiers

DOI

10.1172/JCI0215302

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14 September 2017

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14 September 2017

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PMCID

150920