Role of Mdm4 in drug sensitivity of breast cancer cells (Q39742276)

14 September 2017

title

Role of Mdm4 in drug sensitivity of breast cancer cells (English)

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14 September 2017

S Lam

1

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14 September 2017

K Lodder

2

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14 September 2017

A F A S Teunisse

3

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14 September 2017

M J W E Rabelink

4

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14 September 2017

M Schutte

5

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14 September 2017

A G Jochemsen

6

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14 September 2017

language of work or name

English

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publication date

8 February 2010

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14 September 2017

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14 September 2017

volume

29

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14 September 2017

issue

16

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14 September 2017

page(s)

2415-2426

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MDM2 inhibition sensitizes neuroblastoma to chemotherapy-induced apoptotic cell death

14 September 2017

cites work

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Radiosensitization of lung cancer by nutlin, an inhibitor of murine double minute 2.

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Lentiviral vectors efficiently transduce quiescent mature 3T3-L1 adipocytes

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MDM2 antagonists activate p53 and synergize with genotoxic drugs in B-cell chronic lymphocytic leukemia cells.

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Amplification of Mdmx (or Mdm4) directly contributes to tumor formation by inhibiting p53 tumor suppressor activity

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Hdmx protein stability is regulated by the ubiquitin ligase activity of Mdm2.

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Classic and novel roles of p53: prospects for anticancer therapy

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Mdm2 promotes the rapid degradation of p53

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MDMX overexpression prevents p53 activation by the MDM2 inhibitor Nutlin.

21 January 2018

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Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors.

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E2F-1 transcriptional activity is a critical determinant of Mdm2 antagonist-induced apoptosis in human tumor cell lines

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Regulation of p53 stability by Mdm2

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Inactivation of the p53 pathway in retinoblastoma.

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ATM-mediated phosphorylations inhibit Mdmx/Mdm2 stabilization by HAUSP in favor of p53 activation

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The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

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Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

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Amplification of a gene encoding a p53-associated protein in human sarcomas

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Importance of poly(ADP-ribose) polymerase and its cleavage in apoptosis. Lesson from an uncleavable mutant

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P16INK4a is required for hSNF5 chromatin remodeler-induced cellular senescence in malignant rhabdoid tumor cells

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Differential roles of ATM- and Chk2-mediated phosphorylations of Hdmx in response to DNA damage.

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Phosphorylation of Hdmx mediates its Hdm2- and ATM-dependent degradation in response to DNA damage

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Refined mapping of 1q32 amplicons in malignant gliomas confirms MDM4 as the main amplification target

21 January 2018

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Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition

21 January 2018

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Side effects of adjuvant treatment of breast cancer

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Isolation and identification of the human homolog of a new p53-binding protein, Mdmx

21 January 2018

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Mdmx stabilizes p53 and Mdm2 via two distinct mechanisms

21 January 2018

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Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

21 January 2018

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Regulating the p53 pathway: in vitro hypotheses, in vivo veritas

21 January 2018

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Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy

21 January 2018

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Specific inhibition of gene expression using a stably integrated, inducible small-interfering-RNA vector

21 January 2018

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In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

21 January 2018

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BH3 activation blocks Hdmx suppression of apoptosis and cooperates with Nutlin to induce cell death

21 January 2018

1 reference

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Hdmx modulates the outcome of p53 activation in human tumor cells

21 January 2018

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Thirteen new p53 gene mutants identified among 41 human breast cancer cell lines

21 January 2018

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Levels of HdmX Expression Dictate the Sensitivity of Normal and Transformed Cells to Nutlin-3

21 January 2018

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21 January 2018

Identifiers

DOI

10.1038/ONC.2009.522

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Dimensions Publication ID

14 September 2017

1027801541

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