TGF-beta-FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia (Q39744014)

14 September 2017

title

TGF-beta-FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia (English)

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14 September 2017

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9

Atsushi Hirao

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14 September 2017

Kazuhito Naka

1

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14 September 2017

Takayuki Hoshii

2

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14 September 2017

Teruyuki Muraguchi

3

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14 September 2017

Yuko Tadokoro

4

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14 September 2017

Takako Ooshio

5

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14 September 2017

Yukio Kondo

6

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14 September 2017

Shinji Nakao

7

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14 September 2017

Noboru Motoyama

8

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14 September 2017

language of work or name

English

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publication date

1 February 2010

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14 September 2017

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14 September 2017

volume

463

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14 September 2017

issue

7281

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14 September 2017

page(s)

676-680

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https://scigraph.springernature.com/pub.10.1038/nature08734

14 September 2017

exact match

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cites work

Leukemia stem cells in a genetically defined murine model of blast-crisis CML.

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12 December 2020

Upregulation of the TGFbeta signalling pathway by Bcr-Abl: implications for haemopoietic cell growth and chronic myeloid leukaemia

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12 December 2020

Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome

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12 December 2020

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12 December 2020

Cytokine signals modulated via lipid rafts mimic niche signals and induce hibernation in hematopoietic stem cells

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12 December 2020

Targeting multiple kinase pathways in leukemic progenitors and stem cells is essential for improved treatment of Ph+ leukemia in mice.

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12 December 2020

Foxo3a is essential for maintenance of the hematopoietic stem cell pool.

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12 December 2020

Nilotinib exerts equipotent antiproliferative effects to imatinib and does not induce apoptosis in CD34+ CML cells

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12 December 2020

Dynamic modeling of imatinib-treated chronic myeloid leukemia: functional insights and clinical implications.

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12 December 2020

Efficient and rapid induction of a chronic myelogenous leukemia-like myeloproliferative disease in mice receiving P210 bcr/abl-transduced bone marrow

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12 December 2020

FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress

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12 December 2020

Cytokines and BCR-ABL mediate suppression of TRAIL-induced apoptosis through inhibition of forkhead FOXO3a transcription factor

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12 December 2020

PML targeting eradicates quiescent leukaemia-initiating cells

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12 December 2020

FOXO transcription factor activity is partially retained in quiescent CML stem cells and induced by tyrosine kinase inhibitors in CML progenitor cells

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12 December 2020

Involvement of the c-kit receptor in the adhesion of hematopoietic stem cells to stromal cells

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12 December 2020

Dynamics of chronic myeloid leukaemia.

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12 December 2020

Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia

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12 December 2020

A murine model of CML blast crisis induced by cooperation between BCR/ABL and NUP98/HOXA9

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12 December 2020

Synthesis and activity of new aryl- and heteroaryl-substituted pyrazole inhibitors of the transforming growth factor-beta type I receptor kinase domain

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12 December 2020

Direct transcriptional regulation of Bim by FoxO3a mediates STI571-induced apoptosis in Bcr-Abl-expressing cells.

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12 December 2020

Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia

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12 December 2020

Adult mouse hematopoietic stem cells: purification and single-cell assays.

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12 December 2020

The two TORCs and Akt.

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12 December 2020

Foxo3 is essential for the regulation of ataxia telangiectasia mutated and oxidative stress-mediated homeostasis of hematopoietic stem cells.

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12 December 2020

FoxO transcription factors suppress Myc-driven lymphomagenesis via direct activation of Arf.

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12 December 2020

A member of Forkhead transcription factor FKHRL1 is a downstream effector of STI571-induced cell cycle arrest in BCR-ABL-expressing cells

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12 December 2020

Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro

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12 December 2020

TGF-beta as a candidate bone marrow niche signal to induce hematopoietic stem cell hibernation.

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12 December 2020

Identifiers

DOI

10.1038/NATURE08734

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Dimensions Publication ID

14 September 2017

1047968073

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