Convergent synthesis of alpha-ketoamide inhibitors of Pin1. (Q39764431)

14 September 2017

Convergent synthesis of alpha-ketoamide inhibitors of Pin1. (English)

1 reference

14 September 2017

Felicia A Etzkorn

2

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author name string

Guoyan G Xu

series ordinal

1

1 reference

PMC publication ID

2844255

14 September 2017

language of work or name

English

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publication date

1 February 2010

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14 September 2017

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14 September 2017

12

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14 September 2017

4

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14 September 2017

696-699

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Pin1 as an anticancer drug target

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844255

Phosphorylation-specific prolyl isomerase Pin1 as a new diagnostic and therapeutic target for cancer

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844255

A phosphorylated prodrug for the inhibition of Pin1.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844255

Structural Basis for High-Affinity Peptide Inhibition of Human Pin1

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844255

Nanomolar inhibitors of the peptidyl prolyl cis/trans isomerase Pin1 from combinatorial peptide libraries

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844255

Peptidyl-prolyl isomerase inhibitors

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844255

Development of alpha-keto-based inhibitors of cruzain, a cysteine protease implicated in Chagas disease

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844255

Conformationally locked isostere of phosphoSer-cis-Pro inhibits Pin1 23-fold better than phosphoSer-trans-Pro isostere

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844255

Prevalent overexpression of prolyl isomerase Pin1 in human cancers

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844255

Histone Deacetylase Inhibitors: The Abbott Experience

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844255

Prolyl isomerase Pin1 as a molecular target for cancer diagnostics and therapeutics

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844255

Alpha-keto amides as inhibitors of histone deacetylase

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844255

Synthetic routes and lipase-inhibiting activity of long-chain alpha-keto amides

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844255

Sequence-specific and phosphorylation-dependent proline isomerization: a potential mitotic regulatory mechanism

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844255

Structural and functional analysis of the mitotic rotamase Pin1 suggests substrate recognition is phosphorylation dependent

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844255

A human peptidyl-prolyl isomerase essential for regulation of mitosis

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844255

Molecular basis for the inhibition of human alpha-thrombin by the macrocyclic peptide cyclotheonamide A

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844255

.alpha.-Keto amide inhibitors of aminopeptidases

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844255

Peptidomimetic inhibitors of the human cytomegalovirus protease.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844255

Alpha-keto amide peptides: a synthetic strategy to resin-bound peptide isosteres for protease inhibitor screening on solid support

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844255

Novel peptidyl alpha-keto amide inhibitors of calpains and other cysteine proteases

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844255

Synthesis of a substrate of protein kinase C and its corresponding phosphopeptide.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844255

Inhibition of FKBP rotamase activity by immunosuppressant FK506: twisted amide surrogate.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844255

Theoretical and experimental investigation of the energetics of cis-trans proline isomerization in peptide models

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844255

Novel, potent P2-P3 pyrrolidine derivatives of ketoamide-based cathepsin K inhibitors

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844255

Investigation of glycine alpha-ketoamide HCV NS3 protease inhibitors: effect of carboxylic acid isosteres

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844255

Regioselective debenzylation of C-glycosyl compounds by boron trichloride.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844255

Serine-cis-proline and serine-trans-proline isosteres: stereoselective synthesis of (Z)- and (E)-alkene mimics by Still-Wittig and Ireland-Claisen rearrangements

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844255

Prolyl isomerase Pin1: a catalyst for oncogenesis and a potential therapeutic target in cancer

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844255

Synthesis and activity studies of conformationally restricted alpha-ketoamide factor Xa inhibitors

20 August 2018

1 reference

12 December 2020

Exploration of orally available calpain inhibitors. Part 3: Dipeptidyl alpha-ketoamide derivatives containing pyridine moiety

1 reference

12 December 2020

Activated ketone based inhibitors of human renin

1 reference

12 December 2020

A mechanism for rotamase catalysis by the FK506 binding protein (FKBP)

1 reference

12 December 2020

Stereospecific synthesis of peptidyl alpha-keto amides as inhibitors of calpain

1 reference

12 December 2020

Cyclotheonamide derivatives: Synthesis and thrombin inhibition. Exploration of specific structure-function issues

1 reference

12 December 2020

The methyl group as a source of structural diversity in heterocyclic chemistry: side chain functionalization of picolines and related heterocycles

1 reference

12 December 2020

Identifiers

DOI

10.1021/OL9027013

1 reference

14 September 2017

1 reference

PMC publication ID

2844255

14 September 2017

PubMed publication ID

20102178

1 reference

PMC publication ID

2844255