N152G, -S, and -T substitutions in CMY-2 β-lactamase increase catalytic efficiency for cefoxitin and inactivation rates for tazobactam (Q39767332)

14 September 2017

N152G, -S, and -T substitutions in CMY-2 β-lactamase increase catalytic efficiency for cefoxitin and inactivation rates for tazobactam (English)

1 reference

14 September 2017

Marion J Skalweit

1

1 reference

14 September 2017

Mei Li

2

1 reference

14 September 2017

Benjamin C Conklin

3

1 reference

14 September 2017

Magdalena A Taracila

4

1 reference

14 September 2017

Rebecca A Hutton

5

1 reference

14 September 2017

language of work or name

English

0 references

publication date

14 January 2013

1 reference

Antimicrobial Agents and Chemotherapy

14 September 2017

1 reference

14 September 2017

57

1 reference

14 September 2017

4

1 reference

14 September 2017

1596-1602

1 reference

describes a project that uses

14 September 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3623365/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

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Hydrolysis spectrum extension of CMY-2-like β-lactamases resulting from structural alteration in the Y-X-N loop

22 September 2017

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22 September 2017

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Substrate selectivity and a novel role in inhibitor discrimination by residue 237 in the KPC-2 beta-lactamase

22 September 2017

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Three decades of beta-lactamase inhibitors

22 September 2017

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Enhancing resistance to cephalosporins in class C beta-lactamases: impact of Gly214Glu in CMY-2.

22 September 2017

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Reduced susceptibility to cefepime among Escherichia coli clinical isolates producing novel variants of CMY-2 beta-lactamase

22 September 2017

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The role of a second-shell residue in modifying substrate and inhibitor interactions in the SHV beta-lactamase: a study of ambler position Asn276.

22 September 2017

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Different intermediate populations formed by tazobactam, sulbactam, and clavulanate reacting with SHV-1 beta-lactamases: Raman crystallographic evidence

22 September 2017

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22 September 2017

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Strategic Design of an Effective -Lactamase Inhibitor: LN-1-255, A 6-ALKYLIDENE-2'-SUBSTITUTED PENICILLIN SULFONE

22 September 2017

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Saturation mutagenesis of Asn152 reveals a substrate selectivity switch in P99 cephalosporinase

22 September 2017

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Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa isolates from Spanish hospitals

22 September 2017

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Effect of the inhibitor-resistant M69V substitution on the structures and populations of trans-enamine beta-lactamase intermediates

22 September 2017

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Interplay of efflux system, ampC, and oprD expression in carbapenem resistance of Pseudomonas aeruginosa clinical isolates

22 September 2017

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Structural consequences of the inhibitor-resistant Ser130Gly substitution in TEM beta-lactamase

22 September 2017

1 reference

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Antibody mapping of the linear epitopes of CMY-2 and SHV-1 beta-lactamases

22 September 2017

1 reference

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Inhibitor-sensitive AmpC beta-lactamase variant produced by an Escherichia coli clinical isolate resistant to oxyiminocephalosporins and cephamycins

22 September 2017

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Following the Reactions of Mechanism-Based Inhibitors with β-Lactamase by Raman Crystallography

22 September 2017

1 reference

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Development of a sensitive and specific enzyme-linked immunosorbent assay for detecting and quantifying CMY-2 and SHV beta-lactamases

22 September 2017

1 reference

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Inhibition of AmpC beta-lactamase through a destabilizing interaction in the active site

22 September 2017

1 reference

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Inactivation of CMY-2 beta-lactamase by tazobactam: initial mass spectroscopic characterization

22 September 2017

1 reference

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Carbapenem activities against Pseudomonas aeruginosa: respective contributions of OprD and efflux systems.

22 September 2017

1 reference

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Kinetic interactions of tazobactam with beta-lactamases from all major structural classes

22 September 2017

1 reference

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Interplay of impermeability and chromosomal beta-lactamase activity in imipenem-resistant Pseudomonas aeruginosa

22 September 2017

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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

22 September 2017

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Substitutions at position 105 in SHV family β-lactamases decrease catalytic efficiency and cause inhibitor resistance

22 September 2017

1 reference

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Mechanistic studies of the inactivation of TEM-1 and P99 by NXL104, a novel non-beta-lactam beta-lactamase inhibitor

15 June 2018

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Extended-spectrum cephalosporinase in Acinetobacter baumannii

15 June 2018

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Extended-spectrum properties of CMY-30, a Val211Gly mutant of CMY-2 cephalosporinase

15 June 2018

1 reference

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Kinetic properties of four plasmid-mediated AmpC beta-lactamases

15 June 2018

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Inhibitor-resistant class A beta-lactamases: consequences of the Ser130-to-Gly mutation seen in Apo and tazobactam structures of the SHV-1 variant

15 June 2018

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Emergence of a cefepime- and cefpirome-resistant Citrobacter freundii clinical isolate harbouring a novel chromosomally encoded AmpC beta-lactamase, CMY-37.

15 June 2018

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Probing active site chemistry in SHV beta-lactamase variants at Ambler position 244. Understanding unique properties of inhibitor resistance

20 August 2018

1 reference

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Understanding resistance to beta-lactams and beta-lactamase inhibitors in the SHV beta-lactamase: lessons from the mutagenesis of SER-130.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3623365

A clinical strain of Escherichia coli possessing CMY-2 plasmid-mediated amp C beta-lactamase: an emerging concern in pediatrics?

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3623365

Unexpected advanced generation cephalosporinase activity of the M69F variant of SHV beta-lactamase

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3623365

Role of asparagine 152 in catalysis of beta-lactam hydrolysis by Escherichia coli AmpC beta-lactamase studied by site-directed mutagenesis.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3623365

Effects of the Val211Gly substitution on molecular dynamics of the CMY-2 cephalosporinase: implications on hydrolysis of expanded-spectrum cephalosporins

20 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23318801

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Mutagenesis of amino acid residues in the SHV-1 beta-lactamase: the premier role of Gly238Ser in penicillin and cephalosporin resistance

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23318801

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1128/AAC.01334-12

1 reference

14 September 2017

1 reference

14 September 2017

1 reference