Discovery of BAF312 (Siponimod), a Potent and Selective S1P Receptor Modulator (Q39769027)

14 September 2017

Discovery of BAF312 (Siponimod), a Potent and Selective S1P Receptor Modulator (English)

1 reference

14 September 2017

Shifeng Pan

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24900670%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Wenqi Gao

3

1 reference

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7 June 2020

Yuan Mi

4

1 reference

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7 June 2020

Yi Fan

5

1 reference

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7 June 2020

Xing Wang

6

1 reference

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7 June 2020

Jianwei Che

8

1 reference

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7 June 2020

Sophie Lefebvre

9

1 reference

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7 June 2020

Yu Chen

10

1 reference

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7 June 2020

Alan Chu

11

1 reference

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7 June 2020

Klaus Hinterding

12

1 reference

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7 June 2020

Anne Gardin

13

1 reference

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7 June 2020

Peter End

14

1 reference

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7 June 2020

Peter Heining

15

1 reference

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7 June 2020

Christian Bruns

16

1 reference

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7 June 2020

Nigel G Cooke

17

1 reference

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7 June 2020

Barbara Nuesslein-Hildesheim

18

1 reference

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7 June 2020

publication date

4 January 2013

1 reference

ACS Medicinal Chemistry Letters

14 September 2017

1 reference

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7 June 2020

volume

4

1 reference

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7 June 2020

issue

3

1 reference

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7 June 2020

page(s)

333-337

1 reference

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Optimization of a Potent, Orally Active S1P1 Agonist Containing a Quinolinone Core.

7 June 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027137

The selective sphingosine 1-phosphate receptor modulator BAF312 redirects lymphocyte distribution and has species-specific effects on heart rate

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027137

Crystal structure of a lipid G protein-coupled receptor

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027137

Insights into the pharmacological relevance of lysophospholipid receptors

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027137

The outs and the ins of sphingosine-1-phosphate in immunity

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027137

Synthetic sphingosine 1-phosphate receptor modulators--opportunities and potential pitfalls

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027137

Sphingosine-1-phosphate and immune regulation: trafficking and beyond

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027137

Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027137

Sphingosine 1-phosphate receptor signaling

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027137

Sphingosine 1-phosphate receptors in health and disease: mechanistic insights from gene deletion studies and reverse pharmacology

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027137

Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027137

Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027137

Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027137

The immune modulator FTY720 targets sphingosine 1-phosphate receptors

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027137

Discovery of novel 1,2,4-thiadiazole derivatives as potent, orally active agonists of sphingosine 1-phosphate receptor subtype 1 (S1P(1)).

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027137

Sphingosine 1-phosphate (S1P) regulates vascular contraction via S1P3 receptor: investigation based on a new S1P3 receptor antagonist

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027137

A monoselective sphingosine-1-phosphate receptor-1 agonist prevents allograft rejection in a stringent rat heart transplantation model

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027137

Immune cell regulation and cardiovascular effects of sphingosine 1-phosphate receptor agonists in rodents are mediated via distinct receptor subtypes.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027137

Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027137

Fused tricyclic indoles as S1P₁ agonists with robust efficacy in animal models of autoimmune disease

20 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24900670

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

FTY720: placebo-controlled study of the effect on cardiac rate and rhythm in healthy subjects

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24900670

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/ML300396R

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24900670%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24900670%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

PubMed publication ID

24900670

1 reference