Role of glucagon in the pathogenesis of diabetes: The status of the controversy (Q39774783)

14 September 2017

1 reference

title

Role of glucagon in the pathogenesis of diabetes: The status of the controversy (English)

1 reference

https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

26 June 2022

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1 reference

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https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

26 June 2022

author name string

R. H. Unger

1

1 reference

PubMed ID

360007

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A360007

26 June 2022

language of work or name

1 reference

1 November 1978

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PubMed ID

360007

full work available at URL

14 September 2017

https://api.elsevier.com/content/article/PII:0026049578902913?httpAccept=text/xml

1 reference

https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

https://api.elsevier.com/content/article/PII:0026049578902913?httpAccept=text/plain

26 June 2022

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https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

26 June 2022

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14 September 2017

27

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14 September 2017

11

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14 September 2017

1691-1709

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The essential role of glucagon in the pathogenesis of diabetes mellitus

14 September 2017

1

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https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

Glucagon: Role in the Hyperglycemia of Diabetes Mellitus

7 April 2023

2

1 reference

https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

Increased "glucagon immunoreactivity" in plasma of totally depancreatized dogs

7 April 2023

5

1 reference

https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

Persistent Pancreatic Glucagon but not Insulin Response to Arginine in Pancreatectomized Dogs

7 April 2023

7

1 reference

https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

Gastric A-cell function in insulin-deprived depancreatized dogs

7 April 2023

8

1 reference

https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

Effect of interaction between insulin and glucagon on glucose turnover and FFA concentration in normal and depancreatized dogs

7 April 2023

9

1 reference

https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

Distribution and properties of glucagon immunoreactivity in the digestive tract of various mammals: An immunohistochemical and immunochemical study

7 April 2023

11

1 reference

https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

Identification of glucagon-producing cells (A cells) in dog gastric mucosa

7 April 2023

12

1 reference

https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

The role of glucagon in the pathogenesis of the endogenous hyperglycemia of diabetes mellitus

7 April 2023

13

1 reference

https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

Pancreatic Glucagon Secretion in Normal and Diabetic Subjects

7 April 2023

14

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https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

Studies of pancreatic alpha cell function in normal and diabetic subjects

7 April 2023

15

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https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

Abnormal alpha-cell function in diabetes. Response to carbohydrate and protein ingestion.

7 April 2023

16

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https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

Abnormalities of glucagon metabolism in untreated diabetes mellitus.

7 April 2023

17

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https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

The effect of experimental insulin deficiency on glucagon secretion

7 April 2023

18

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https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

The Banting Memorial Lecture 1971. Physiology of insulin in man.

7 April 2023

22

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https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

The Banting Memorial Lecture 1975. Diabetes and the alpha cell

7 April 2023

25

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https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

Abnormal alpha cell function in diabetics response to insulin.

7 April 2023

26

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https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

Glucagon and diabetes. II. Complete suppression of glucagon by insulin in human diabetes

7 April 2023

27

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https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

Measurements of endogenous glucagon in plasma and the influence of blood glucose concentration upon its secretion

7 April 2023

28

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https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

Control of Pancreatic Glucagon Secretion by Glucose

7 April 2023

29

1 reference

https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

Abnormal alpha cell function in human diabetes: the response to oral protein

7 April 2023

30

1 reference

https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

Lack of glucagon response to hypoglycemia in diabetes: evidence for an intrinsic pancreatic alpha cell defect.

7 April 2023

31

1 reference

https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

Comparison of the suppressive effects of elevated plasma glucose and free fatty acid levels on glucagon secretion in normal and insulin-dependent diabetic subjects. Evidence for selective alpha-cell insensitivity to glucose in diabetes mellitus

7 April 2023

32

1 reference

https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

Evaluation of Alpha-Cell Function by Infusion of Alanine in Normal, Diabetic and Obese Subjects

7 April 2023

33

1 reference

https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

Effect of insulin-glucose infusions on plasma glucagon levels in fasting diabetics and nondiabetics

7 April 2023

34

1 reference

https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

Normalization of fasting hyperglucagonemia and excessive glucagon responses to intravenous arginine in human diabetes mellitus by prolonged infusion of insulin

7 April 2023

35

1 reference

https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

Effect of Insulin on the Exaggerated Glucagon Response to Arginine Stimulation in Diabetes Mellitus

7 April 2023

36

1 reference

https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

The effects of acute and chronic insulin administration on plasma IRG levels in human diabetes

7 April 2023

37

1 reference

https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

Glucagon Secretion from the Perfused Pancreas of Streptozotocin-treated Rats

7 April 2023

40

1 reference

https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

Possible Roles of the Pancreatic D-cell in the Normal and Diabetic States

7 April 2023

41

1 reference

https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

Immunoreactive glucagon (IRG) responses to intravenous glucose in prediabetes and diabetes among Pima Indians and normal Caucasians

7 April 2023

43

1 reference

https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

Glucose Suppression of Glucagon: Relationship to Pancreatic Beta Cell Function?

7 April 2023

44

1 reference

https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

Decreased pancreatic somatostatin (SRIF) concentration in spontaneously diabetic mice

7 April 2023

45

1 reference

https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

Somatostatin: Widespread Abnormality in Tissues of Spontaneously Diabetic Mice

7 April 2023

46

1 reference

https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

Effect of glucagon on glucose production during insulin deficiency in the dog

7 April 2023

48

1 reference

https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

Effects of physiologic levels of glucagon and growth hormone on human carbohydrate and lipid metabolism. Studies involving administration of exogenous hormone during suppression of endogenous hormone secretion with somatostatin

7 April 2023

50

1 reference

https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

The roles of insulin, glucagon, and free fatty acids in the regulation of ketogenesis in dogs

7 April 2023

51

1 reference

https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

Role of glucagon and other hormones in development of diabetic ketoacidosis

7 April 2023

52

1 reference

https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

Hormonal control of ketogenesis. Rapid activation of hepatic ketogenic capacity in fed rats by anti-insulin serum and glucagon

7 April 2023

53

1 reference

https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

Role of carnitine in hepatic ketogenesis

7 April 2023

54

1 reference

https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

A possible role for malonyl-CoA in the regulation of hepatic fatty acid oxidation and ketogenesis

7 April 2023

55

1 reference

https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

Pancreatic somatostatinoma. Clinical features and physiological implications

7 April 2023

56

1 reference

https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

“Somatostatinoma”: A Somatostatin-Containing Tumor of the Endocrine Pancreas

7 April 2023

57

1 reference

https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

The role of glucagon deficiency in the Houssay phenomenon of dogs

7 April 2023

59

1 reference

https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

Is glucagon important in stable insulin-dependent diabetics?

7 April 2023

60

1 reference

https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

Antagonism Between the Effects of Insulin and Glucagon on the Isolated Liver

7 April 2023

62

1 reference

https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

Glucagon and the Insulin:Glucagon Ratio in Diabetes and Other Catabolic Illnesses

7 April 2023

63

1 reference

https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

Concentration of Cyclic AMP in Rat Liver as a Function of the Insulin/Glucagon Ratio in Blood under Standardized Physiological Conditions11

7 April 2023

64

1 reference

https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

Glucose homeostasis during prolonged suppression of glucagon and insulin secretion by somatostatin

7 April 2023

65

1 reference

https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

Metabolic effects of somatostatin in maturity-onset diabetes.

7 April 2023

66

1 reference

https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

Influence of glucagon replacement on the hyperglycemic and hyperketonemic response to prolonged somatostatin infusion in normal man

7 April 2023

67

1 reference

https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

Failure of somatostatin to correct manifest diabetic ketoacidosis

7 April 2023

68

1 reference

https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

Modulation of fatty acid metabolism by glucagon in man. IV. Effects of a physiologic hormone infusion in normal man

7 April 2023

69

1 reference

https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

Ketoacidosis in Pancreatectomized Man

7 April 2023

70

1 reference

https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

Studies of Glucagon Secretion in Pancreatectomized Patients

7 April 2023

71

1 reference

https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

Immunoreactive glucagon responses to arginine in three pancreatectomized humans

7 April 2023

72

1 reference

https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

Plasma glucagon after total resection of the pancreas in man

7 April 2023

73

1 reference

https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

Glucagon levels in normal and diabetic subjects: use of a specific immunoabsorbent for glucagon radioimmunoassay

7 April 2023

74

1 reference

https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

Hyperglucagonemia and Blood Glucose Regulation in Normal, Obese and Diabetic Subjects

7 April 2023

76

1 reference

https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

The role of insulin and glucagon in the regulation of basal glucose production in the postabsorptive dog

7 April 2023

77

1 reference

https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

Influence of physiologic hyperglucagonemia on basal and insulin-inhibited splanchnic glucose output in normal man

7 April 2023

78

1 reference

https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

Evidence for an important role of glucagon in the regulation of hepatic glucose production in normal man.

7 April 2023

79

1 reference

https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

Arginine infusion in dogs. Model for the roles of insulin and glucagon in regulating glucose turnover and free fatty acid levels

7 April 2023

80

1 reference

https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

Effect of interaction between insulin and glucagon on glucose turnover and FFA concentration in normal and depancreatized dogs

7 April 2023

81

1 reference

https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

Effects of Exogenous Hyperglucagonemia in Insulin-treated Diabetics

7 April 2023

82

1 reference

https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

The effects of glucagon administration to nondiabetics and diabetics

7 April 2023

83

1 reference

https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

Transient Stimulatory Effect of Sustained Hyperglucagonemia on Splanchnic Glucose Production in Normal and Diabetic Man

7 April 2023

84

1 reference

https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

The effect of intraportal and peripheral infusions of glucagon on insulin and glucose concentrations and glucose tolerance in normal man

7 April 2023

87

1 reference

https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

The effect of hyperglucagonemia on blood glucose concentrations and on insulin requirements in insulin-requiring diabetes mellitus

7 April 2023

89

1 reference

https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

Inhibition of insulin secretion by somatostatin

7 April 2023

90

1 reference

https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

Hypothalamic Polypeptide That Inhibits the Secretion of Immunoreactive Pituitary Growth Hormone

7 April 2023

91

1 reference

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Inhibition of gastrin and gastric-acid secretion by growth-hormone release-inhibiting hormone.

7 April 2023

92

1 reference

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Direct inhibition of gastric acid and pepsin secretion by growth-hormone release-inhibiting hormone in cats

7 April 2023

93

1 reference

https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

The effect of somatostatin on release and insulinotropic action of gastric inhibitory polypeptide

7 April 2023

94

1 reference

https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

Somatostatin suppresses secretin and pancreatic exocrine secretion

7 April 2023

95

1 reference

https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

Inhibition of cholecystokinin-pancreozymin release by somatostatin

7 April 2023

99

1 reference

https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

Metabolic effects of long-term somatostatin infusion in man

7 April 2023

101

1 reference

https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

Influence of somatostatin on carbohydrate disposal and absorption in diabetes mellitus

7 April 2023

103

1 reference

https://api.crossref.org/works/10.1016/0026-0495(78)90291-3

7 April 2023

Identifiers

1 reference

14 September 2017

1 reference

PubMed ID

360007