Synthesis and Pharmacological Characterization of Two Novel, Brain Penetrating P2X7 Antagonists (Q39776124)

14 September 2017

Synthesis and Pharmacological Characterization of Two Novel, Brain Penetrating P2X7 Antagonists (English)

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14 September 2017

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Michael A Letavic

1

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14 September 2017

Brian Lord

2

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14 September 2017

Francois Bischoff

3

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14 September 2017

Natalie A Hawryluk

4

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14 September 2017

Serge Pieters

5

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14 September 2017

Jason C Rech

6

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14 September 2017

Zachary Sales

7

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14 September 2017

Adriana I Velter

8

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14 September 2017

Hong Ao

9

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14 September 2017

Pascal Bonaventure

10

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14 September 2017

Victor Contreras

11

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14 September 2017

Xiaohui Jiang

12

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14 September 2017

Kirsten L Morton

13

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14 September 2017

Brian Scott

14

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14 September 2017

Qi Wang

15

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14 September 2017

Alan D Wickenden

16

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14 September 2017

Nicholas I Carruthers

17

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14 September 2017

Anindya Bhattacharya

18

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14 September 2017

language of work or name

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12 March 2013

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ACS Medicinal Chemistry Letters

14 September 2017

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14 September 2017

4

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14 September 2017

4

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14 September 2017

419-422

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The inflammasome: pathways linking psychological stress, depression, and systemic illnesses

14 September 2017

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The role of the innate immune system in psychiatric disorders

22 September 2017

1 reference

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The absence of P2X7 receptors (P2rx7) on non-haematopoietic cells leads to selective alteration in mood-related behaviour with dysregulated gene expression and stress reactivity in mice.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027403

Evidence for IL-1 receptor blockade as a therapeutic strategy for the treatment of depression

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027403

Antagonists of the P2X(7) receptor. From lead identification to drug development.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027403

IL-1beta is an essential mediator of the antineurogenic and anhedonic effects of stress

22 September 2017

1 reference

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Receptors for purines and pyrimidines

22 September 2017

1 reference

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Efficacy and safety of CE-224,535, an antagonist of P2X7 receptor, in treatment of patients with rheumatoid arthritis inadequately controlled by methotrexate

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027403

Optimization of the physicochemical and pharmacokinetic attributes in a 6-azauracil series of P2X7 receptor antagonists leading to the discovery of the clinical candidate CE-224,535.

17 June 2018

1 reference

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Identification of 2-oxo-N-(phenylmethyl)-4-imidazolidinecarboxamide antagonists of the P2X7 receptor

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027403

Discovery and structure-activity relationships of a series of pyroglutamic acid amide antagonists of the P2X7 receptor

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027403

Discovery of potent and selective adamantane-based small-molecule P2X(7) receptor antagonists/interleukin-1beta inhibitors

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027403

Minocycline attenuates mechanical allodynia and proinflammatory cytokine expression in rat models of pain facilitation

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027403

Hit-to-Lead studies: The discovery of potent adamantane amide P2X7 receptor antagonists

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027403

Brain interleukin-1 mediates chronic stress-induced depression in mice via adrenocortical activation and hippocampal neurogenesis suppression

20 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24900687

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The P2X7receptor as a therapeutic target

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24900687

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/ML400040V

1 reference

14 September 2017

1 reference

14 September 2017

PubMed publication ID

24900687

1 reference