Reexpression of epigenetically silenced AML tumor suppressor genes by SUV39H1 inhibition (Q39780644)

14 September 2017

Reexpression of epigenetically silenced AML tumor suppressor genes by SUV39H1 inhibition (English)

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14 September 2017

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A Lakshmikuttyamma

1

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14 September 2017

S A Scott

series ordinal

2

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14 September 2017

J F DeCoteau

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3

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14 September 2017

C R Geyer

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4

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14 September 2017

language of work or name

English

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publication date

2 November 2009

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14 September 2017

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14 September 2017

29

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4

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14 September 2017

576-588

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https://scigraph.springernature.com/pub.10.1038/onc.2009.361

14 September 2017

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Gene silencing by DNA methylation in haematological malignancies

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Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer

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Recruitment of the histone methyltransferase SUV39H1 and its role in the oncogenic properties of the leukemia-associated PML-retinoic acid receptor fusion protein

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EVI1 recruits the histone methyltransferase SUV39H1 for transcription repression

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SUV39H1 interacts with AML1 and abrogates AML1 transactivity. AML1 is methylated in vivo

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Methylation of p15INK4B is common, is associated with deletion of genes on chromosome arm 7q and predicts a poor prognosis in therapy-related myelodysplasia and acute myeloid leukemia.

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Resetting the histone code at CDKN2A in HNSCC by inhibition of DNA methylation

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KG-1 and KG-1a model the p15 CpG island methylation observed in acute myeloid leukemia patients.

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Inhibition of histone deacetylation does not block resilencing of p16 after 5-aza-2'-deoxycytidine treatment

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Epigenetics in human disease and prospects for epigenetic therapy

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Methyl-CpG binding domain 1 (MBD1) interacts with the Suv39h1-HP1 heterochromatic complex for DNA methylation-based transcriptional repression

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The DNA methyltransferases associate with HP1 and the SUV39H1 histone methyltransferase

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The methyl-CpG-binding protein MeCP2 links DNA methylation to histone methylation

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The fundamental role of epigenetics in hematopoietic malignancies

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The clinical application of targeting cancer through histone acetylation and hypomethylation

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Combination therapy with DNA methyltransferase inhibitors in hematologic malignancies

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Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9.

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Profiling DNA methylation by melting analysis

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Gene silencing in cancer in association with promoter hypermethylation

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Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands

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Cabin1 represses MEF2 transcriptional activity by association with a methyltransferase, SUV39H1.

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p21(WAF1/CIP1) induction by 5-azacytosine nucleosides requires DNA damage.

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SUV39H1 interacts with HTLV-1 Tax and abrogates Tax transactivation of HTLV-1 LTR.

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The oncoprotein Evi-1 represses TGF-beta signalling by inhibiting Smad3

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Critical role of histone methylation in tumor suppressor gene silencing in colorectal cancer.

21 January 2018

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Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins

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Suv39h-mediated histone H3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatin

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Does heterochromatin protein 1 always follow code?

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Regulatory mechanisms controlling human E-cadherin gene expression

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pRb2/p130-E2F4/5-HDAC1-SUV39H1-p300 and pRb2/p130-E2F4/5-HDAC1-SUV39H1-DNMT1 multimolecular complexes mediate the transcription of estrogen receptor-alpha in breast cancer

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Histone methyltransferase Suv39h1 represses MyoD-stimulated myogenic differentiation

21 January 2018

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DNA methylation and complete transcriptional silencing of cancer genes persist after depletion of EZH2.

21 January 2018

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Silencing of transgene transcription precedes methylation of promoter DNA and histone H3 lysine 9.

21 January 2018

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Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence

21 January 2018

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Balance between acetylation and methylation of histone H3 lysine 9 on the E2F-responsive dihydrofolate reductase promoter

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2009.361

Heterochromatin formation in mammalian cells: interaction between histones and HP1 proteins

21 January 2018

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Rb targets histone H3 methylation and HP1 to promoters

21 January 2018

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RIZ1 repression is associated with insulin-like growth factor-1 signaling activation in chronic myeloid leukemia cell lines

21 January 2018

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Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability

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Polymerase chain reaction-aided genomic sequencing of an X chromosome-linked CpG island: methylation patterns suggest clonal inheritance, CpG site autonomy, and an explanation of activity state stability

21 January 2018

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Inhibition of SIRT1 reactivates silenced cancer genes without loss of promoter DNA hypermethylation

21 January 2018

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Regulation of chromatin structure by site-specific histone H3 methyltransferases

21 January 2018

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Histone methyltransferases direct different degrees of methylation to define distinct chromatin domains

21 January 2018

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5-Aza-2'-deoxycytidine (decitabine) can relieve p21WAF1 repression in human acute myeloid leukemia by a mechanism involving release of histone deacetylase 1 (HDAC1) without requiring p21WAF1 promoter demethylation.

21 January 2018

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Zebularine inhibits human acute myeloid leukemia cell growth in vitro in association with p15INK4B demethylation and reexpression.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2009.361

A novel interaction between the proto-oncogene Evi1 and histone methyltransferases, SUV39H1 and G9a

21 January 2018

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A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer

21 January 2018

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G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2009.361

Hypermethylation of GpG islands in the promoter region of p15(INK4b) in acute promyelocytic leukemia represses p15(INK4b) expression and correlates with poor prognosis.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2009.361

Transcriptional repression by the retinoblastoma protein through the recruitment of a histone methyltransferase

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2009.361

5-Aza-2'-deoxycytidine-mediated reductions in G9A histone methyltransferase and histone H3 K9 di-methylation levels are linked to tumor suppressor gene reactivation

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2009.361

Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2009.361

Transcriptional silencing of the TMS1/ASC tumour suppressor gene by an epigenetic mechanism in hepatocellular carcinoma cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2009.361

hTERT is expressed in cancer cell lines despite promoter DNA methylation by preservation of unmethylated DNA and active chromatin around the transcription start site

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2009.361

Combined DNA methyltransferase and histone deacetylase inhibition in the treatment of myeloid neoplasms

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2009.361

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2009.361

Analysis of histone modification around the CpG island region of the p15 gene in acute myeloblastic leukemia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.361

P15INK4B gene methylation and expression in normal, myelodysplastic, and acute myelogenous leukemia cells and in the marrow cells of cured lymphoma patients

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2009.361

Methylation of p15(INK4b) and E-cadherin genes is independently correlated with poor prognosis in acute myeloid leukemia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.361

DNA methylation analysis by pyrosequencing

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.361

31 March 2020

Identifiers

DOI

10.1038/ONC.2009.361

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Dimensions Publication ID

14 September 2017

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