An AlphaScreen®-based assay for high-throughput screening for specific inhibitors of nuclear import. (Q39786029)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21297106%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

title

An AlphaScreen®-based assay for high-throughput screening for specific inhibitors of nuclear import (English)

1 reference

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21 January 2020

1

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21 January 2020

Stephen M Rawlinson

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21297106%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

David A Jans

series ordinal

4

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21297106%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

author name string

Anna C Hearps

series ordinal

3

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21 January 2020

publication date

1 February 2011

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21297106%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biomolecular Screening

21 January 2020

published in

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21 January 2020

volume

16

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21 January 2020

page(s)

192-200

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21 January 2020

issue

2

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Nuclear localization of dengue virus nonstructural protein 5 through its importin alpha/beta-recognized nuclear localization sequences is integral to viral infection.

21 January 2020

cites work

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Nuclear import of the respiratory syncytial virus matrix protein is mediated by importin beta1 independent of importin alpha

21 January 2018

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Nucleocytoplasmic distribution of rabies virus P-protein is regulated by phosphorylation adjacent to C-terminal nuclear import and export signals

21 January 2018

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Dynein light chain association sequences can facilitate nuclear protein import

21 January 2018

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Mechanisms of Receptor-Mediated Nuclear Import and Nuclear Export

21 January 2018

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Regulation of nuclear transport: central role in development and transformation?

21 January 2018

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Nuclear import pathway of the telomere elongation suppressor TRF1: inhibition by importin alpha.

21 January 2018

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Nuclear Import of Creb and AP-1 Transcription Factors Requires Importin-β1 and Ran but Is Independent of Importin-α

21 January 2018

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Importin beta recognizes parathyroid hormone-related protein with high affinity and mediates its nuclear import in the absence of importin alpha

21 January 2018

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A chemical genetic screen identifies inhibitors of regulated nuclear export of a Forkhead transcription factor in PTEN-deficient tumor cells

21 January 2018

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Nuclear transport as a target for cell growth

21 January 2018

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Ratjadone and leptomycin B block CRM1-dependent nuclear export by identical mechanisms.

21 January 2018

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Identification of nuclear export inhibitors with potent anticancer activity in vivo

21 January 2018

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Association of integrase, matrix, and reverse transcriptase antigens of human immunodeficiency virus type 1 with viral nucleic acids following acute infection

21 January 2018

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Nuclear import of the pre-integration complex (PIC): the Achilles heel of HIV?

21 January 2018

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HIV-1 integrase is capable of targeting DNA to the nucleus via an importin alpha/beta-dependent mechanism.

21 January 2018

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Intramolecular masking of nuclear localization signals: analysis of importin binding using a novel AlphaScreen-based method.

21 January 2018

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Role of prodomain in importin-mediated nuclear localization and activation of caspase-2

21 January 2018

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Histone-mediated transduction as an efficient means for gene delivery.

21 January 2018

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Interacting residues in the extracellular region of the common beta subunit of the human granulocyte-macrophage colony-stimulating factor, interleukin (IL)-3, and IL-5 receptors involved in constitutive activation.

21 January 2018

1 reference

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The protein kinase CK2 site (Ser111/112) enhances recognition of the simian virus 40 large T-antigen nuclear localization sequence by importin

21 January 2018

1 reference

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The cAMP-dependent protein kinase site (Ser312) enhances dorsal nuclear import through facilitating nuclear localization sequence/importin interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110390360

The BRCA-1 binding protein BRAP2 is a novel, negative regulator of nuclear import of viral proteins, dependent on phosphorylation flanking the nuclear localization signal.

21 January 2018

1 reference

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Quantitative analysis of protein-protein interactions by native page/fluorimaging.

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057110390360

Efficient gene delivery using reconstituted chromatin enhanced for nuclear targeting.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110390360

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110390360

CRM1-mediated Nuclear Export of Dengue Virus RNA Polymerase NS5 Modulates Interleukin-8 Induction and Virus Production

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110390360

Apoptin nuclear accumulation is modulated by a CRM1-recognized nuclear export signal that is active in normal but not in tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110390360

A tumor cell-specific nuclear targeting signal within chicken anemia virus VP3/apoptin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110390360

In vitro genotoxic and cytotoxic effects of ivermectin and its formulation ivomec on Chinese hamster ovary (CHOK1) cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110390360

A comparative study examining the cytotoxicity of inducible gene expression system ligands in different cell types

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110390360

CRM1 is responsible for intracellular transport mediated by the nuclear export signal

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110390360

Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110390360

Structure-based design of a pathway-specific nuclear import inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110390360

The N-terminal basic domain of the HIV-1 matrix protein does not contain a conventional nuclear localization sequence but is required for DNA binding and protein self-association.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110390360

Productive human immunodeficiency virus type 1 (HIV-1) infection of nonproliferating human monocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110390360

Antiviral effects of mifepristone on human immunodeficiency virus type-1 (HIV-1): targeting Vpr and its cellular partner, the glucocorticoid receptor (GR).

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057110390360

HIV drug development: the next 25 years

21 January 2018

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https://api.crossref.org/works/10.1177%2F1087057110390360