Effects of genetic variation in the novel organic cation transporter, OCTN1, on the renal clearance of gabapentin (Q39803558)

14 September 2017

Effects of genetic variation in the novel organic cation transporter, OCTN1, on the renal clearance of gabapentin (English)

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14 September 2017

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T J Urban

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14 September 2017

C Brown

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R A Castro

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N Shah

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R Mercer

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Y Huang

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C M Brett

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E G Burchard

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K M Giacomini

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language of work or name

English

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publication date

4 July 2007

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Clinical Pharmacology & Therapeutics

14 September 2017

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14 September 2017

83

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14 September 2017

416-421

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14 September 2017

3

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Gabapentin in the management of convulsive disorders

14 September 2017

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Gabapentin dosing for neuropathic pain: evidence from randomized, placebo-controlled clinical trials

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Use of antiepileptic drugs for nonepileptic conditions: psychiatric disorders and chronic pain

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Efficacy of gabapentin in migraine prophylaxis

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Population pharmacokinetics of gabapentin in infants and children

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Repeat administration of drugs as a means to assess the genetic component in pharmacological variability

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Transport of amino acid-related compounds mediated by L-type amino acid transporter 1 (LAT1): insights into the mechanisms of substrate recognition

21 January 2018

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Functional variants of OCTN cation transporter genes are associated with Crohn disease

21 January 2018

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Functional role of the 503F variant of the organic cation transporter OCTN1 in Crohn's disease

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Discovery of the ergothioneine transporter

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A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group

21 January 2018

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Genetic polymorphisms of drug transporters: pharmacokinetic and pharmacodynamic consequences in pharmacotherapy

21 January 2018

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Involvement of OCTN1 (SLC22A4) in pH-dependent transport of organic cations.

21 January 2018

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Natural variation in human membrane transporter genes reveals evolutionary and functional constraints

21 January 2018

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Functional genomics of membrane transporters in human populations

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Haplotype structure and ethnic-specific allele frequencies at the OCTN locus: implications for the genetics of Crohn's disease

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Effects of age and gender on single-dose pharmacokinetics of gabapentin

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7 January 2021

A saturable transport mechanism in the intestinal absorption of gabapentin is the underlying cause of the lack of proportionality between increasing dose and drug levels in plasma

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7 January 2021

Gabapentin bioavailability: effect of dose and frequency of administration in adult patients with epilepsy

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Inter- and intra-subject variability in gabapentin absorption and absolute bioavailability

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Hypothesis: comparisons of inter- and intra-individual variations can substitute for twin studies in drug research

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7 January 2021

Prediction of creatinine clearance from serum creatinine

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Molecular and physiological evidence for multifunctionality of carnitine/organic cation transporter OCTN2.

1 reference

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7 January 2021

Identifiers

DOI

10.1038/SJ.CLPT.6100271

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release_o4thwfqu4vhwjd4vpslnefuio4

14 September 2017

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