The HIF1alpha-inducible pro-cell death gene BNIP3 is a novel target of SIM2s repression through cross-talk on the hypoxia response element (Q39814313)

14 September 2017

The HIF1alpha-inducible pro-cell death gene BNIP3 is a novel target of SIM2s repression through cross-talk on the hypoxia response element (English)

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14 September 2017

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hypoxia response element

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A L Farrall

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PubMed ID

19668230

14 September 2017

M L Whitelaw

series ordinal

2

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PubMed ID

19668230

14 September 2017

language of work or name

English

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publication date

10 August 2009

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14 September 2017

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14 September 2017

28

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14 September 2017

41

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14 September 2017

3671-3680

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https://scigraph.springernature.com/pub.10.1038/onc.2009.228

14 September 2017

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Two new members of the murine Sim gene family are transcriptional repressors and show different expression patterns during mouse embryogenesis

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How to interpret LC3 immunoblotting

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The murine Sim-2 gene product inhibits transcription by active repression and functional interference

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Upregulation of BNIP3 by 5-aza-2'-deoxycytidine sensitizes pancreatic cancer cells to hypoxia-mediated cell death.

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Inhibition of Single Minded 2 gene expression mediates tumor-selective apoptosis and differentiation in human colon cancer cells

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Selective silencing of the hypoxia-inducible factor 1 target gene BNIP3 by histone deacetylation and methylation in colorectal cancer

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Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia

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The role of Bcl-2 family member BNIP3 in cell death and disease: NIPping at the heels of cell death.

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Differences in gene expression in prostate cancer, normal appearing prostate tissue adjacent to cancer and prostate tissue from cancer free organ donors

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Cloning of two human homologs of the Drosophila single-minded gene SIM1 on chromosome 6q and SIM2 on 21q within the Down syndrome chromosomal region

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Pivotal role of the cell death factor BNIP3 in ceramide-induced autophagic cell death in malignant glioma cells.

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Identification of Down's syndrome critical locus gene SIM2-s as a drug therapy target for solid tumors

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Loss of BNIP3 expression is a late event in pancreatic cancer contributing to chemoresistance and worsened prognosis

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Sim2 mutants have developmental defects not overlapping with those of Sim1 mutants

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Reevaluation of the PPAR-β/δ Ligand Binding Domain Model Reveals Why It Exhibits the Activated Form

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S100A4 contributes to the suppression of BNIP3 expression, chemoresistance, and inhibition of apoptosis in pancreatic cancer

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BNIP3 is an RB/E2F target gene required for hypoxia-induced autophagy

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Integrative genomic and proteomic analysis of prostate cancer reveals signatures of metastatic progression

31 March 2020

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The bHLH/Per-Arnt-Sim transcription factor SIM2 regulates muscle transcript myomesin2 via a novel, non-canonical E-box sequence

31 March 2020

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Differential activities of murine single minded 1 (SIM1) and SIM2 on a hypoxic response element. Cross-talk between basic helix-loop-helix/per-Arnt-Sim homology transcription factors

31 March 2020

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Gene expression alterations in prostate cancer predicting tumor aggression and preceding development of malignancy.

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Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/ONC.2009.228

1 reference

14 September 2017

1 reference

PubMed ID

19668230