Reciprocal effects of alpha-synuclein overexpression and proteasome inhibition in neuronal cells and tissue (Q39817121)

14 September 2017

Reciprocal effects of alpha-synuclein overexpression and proteasome inhibition in neuronal cells and tissue (English)

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14 September 2017

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Peter-Michael Kloetzel

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object named as

Peter-Michael Kloetzel

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author name string

Melanie Dyllick-Brenzinger

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14 September 2017

Cheryl A D'Souza

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14 September 2017

Burkhardt Dahlmann

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14 September 2017

Anurag Tandon

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14 September 2017

4 August 2009

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14 September 2017

Neurotoxicity Research

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14 September 2017

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14 September 2017

215-227

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https://scigraph.springernature.com/pub.10.1007/s12640-009-9094-1

14 September 2017

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cites work

Redox imbalance in Parkinson's disease

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Crossref

https://api.crossref.org/works/10.1007%2FS12640-009-9094-1

Selective insolubility of alpha-synuclein in human Lewy body diseases is recapitulated in a transgenic mouse model

21 January 2018

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Crossref

https://api.crossref.org/works/10.1007%2FS12640-009-9094-1

Proteasome inhibition alters neural mitochondrial homeostasis and mitochondria turnover

21 January 2018

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12 December 2020

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

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12 December 2020

Failure of the ubiquitin-proteasome system in Parkinson's disease

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12 December 2020

Reproducible nigral cell loss after systemic proteasomal inhibitor administration to rats.

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12 December 2020

Rat alpha-synuclein interacts with Tat binding protein 1, a component of the 26S proteasomal complex

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12 December 2020

Subcellular localization of wild-type and Parkinson's disease-associated mutant alpha -synuclein in human and transgenic mouse brain

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12 December 2020

Depletion of 26S proteasomes in mouse brain neurons causes neurodegeneration and Lewy-like inclusions resembling human pale bodies.

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12 December 2020

The A53T alpha-synuclein mutation increases iron-dependent aggregation and toxicity

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12 December 2020

Dysfunction of mitochondrial complex I and the proteasome: interactions between two biochemical deficits in a cellular model of Parkinson's disease.

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12 December 2020

Proteasome inhibitor-induced model of Parkinson's disease

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12 December 2020

Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein

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12 December 2020

Systemic exposure to proteasome inhibitors causes a progressive model of Parkinson's disease

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12 December 2020

Novel covalent modifications of alpha-synuclein during the recovery from proteasomal dysfunction

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12 December 2020

Autophagy in yeast: mechanistic insights and physiological function

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12 December 2020

Proteasomal function is impaired in substantia nigra in Parkinson's disease

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12 December 2020

Stabilization of alpha-synuclein protein with aging and familial parkinson's disease-linked A53T mutation.

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12 December 2020

Oxidative dimer formation is the critical rate-limiting step for Parkinson's disease alpha-synuclein fibrillogenesis

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12 December 2020

Systemic administration of a proteasome inhibitor does not cause nigrostriatal dopamine degeneration.

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12 December 2020

Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis

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12 December 2020

Inhibition of proteasome activity induces concerted expression of proteasome genes and de novo formation of Mammalian proteasomes

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12 December 2020

alpha-Synuclein expression levels do not significantly affect proteasome function and expression in mice and stably transfected PC12 cell lines

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12 December 2020

Proteasome dysfunction in aged human alpha-synuclein transgenic mice.

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12 December 2020

Alpha-synuclein protects cerebellar granule neurons against 6-hydroxydopamine-induced death

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12 December 2020

Multiple forms of the 20 S multicatalytic and the 26 S ubiquitin/ATP-dependent proteases from rabbit reticulocyte lysate

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12 December 2020

Oxidative and nitrative protein modifications in Parkinson's disease

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12 December 2020

The precursor protein of non-A beta component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system

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12 December 2020

Lack of nigrostriatal pathology in a rat model of proteasome inhibition.

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12 December 2020

Synphilin-1 degradation by the ubiquitin-proteasome pathway and effects on cell survival

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12 December 2020

Proteasomal inhibition leads to formation of ubiquitin/alpha-synuclein-immunoreactive inclusions in PC12 cells

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12 December 2020

Proteasomal inhibition by alpha-synuclein filaments and oligomers.

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12 December 2020

Characterization of the precursor protein of the non-A beta component of senile plaques (NACP) in the human central nervous system.

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12 December 2020

Proteasome inhibition causes nigral degeneration with inclusion bodies in rats

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12 December 2020

alpha-Synuclein protofibrils inhibit 26 S proteasome-mediated protein degradation: understanding the cytotoxicity of protein protofibrils in neurodegenerative disease pathogenesis.

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12 December 2020

Proteasome inhibition and Parkinson's disease modeling

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12 December 2020

Understanding cell death in Parkinson's disease.

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12 December 2020

Proteasomal inhibition-induced inclusion formation and death in cortical neurons require transcription and ubiquitination

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12 December 2020

The biochemistry of Parkinson's disease

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12 December 2020

Molecular Pathways of Neurodegeneration in Parkinson's Disease

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12 December 2020

Alpha-synuclein in Lewy bodies

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12 December 2020

Failure of proteasome inhibitor administration to provide a model of Parkinson's disease in rats and monkeys.

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12 December 2020

alpha-Synuclein is phosphorylated in synucleinopathy lesions

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12 December 2020

Aggregated and monomeric alpha-synuclein bind to the S6' proteasomal protein and inhibit proteasomal function

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12 December 2020

Impairment of the ubiquitin-proteasome system causes dopaminergic cell death and inclusion body formation in ventral mesencephalic cultures

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12 December 2020

Autophagy in neuroprotection and neurodegeneration: A question of balance.

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12 December 2020

alpha-Synuclein protects SH-SY5Y cells from dopamine toxicity

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12 December 2020

Cytosolic proteins regulate alpha-synuclein dissociation from presynaptic membranes.

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12 December 2020

Ubiquitination of alpha-synuclein in Lewy bodies is a pathological event not associated with impairment of proteasome function

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12 December 2020

Mitochondrial dysfunction is involved in apoptosis induced by serum withdrawal and fatty acids in the beta-cell line INS-1.

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12 December 2020

Expression of A53T mutant but not wild-type alpha-synuclein in PC12 cells induces alterations of the ubiquitin-dependent degradation system, loss of dopamine release, and autophagic cell death.

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12 December 2020

Dityrosine cross-linking promotes formation of stable alpha -synuclein polymers. Implication of nitrative and oxidative stress in the pathogenesis of neurodegenerative synucleinopathies

1 reference

12 December 2020

10.1007/S12640-009-9094-1

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DOI

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14 September 2017

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