Opportunities in metabolic engineering to facilitate scalable alkaloid production (Q39859222)

15 September 2017

title

Opportunities in metabolic engineering to facilitate scalable alkaloid production (English)

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15 September 2017

3

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author name string

Effendi Leonard

series ordinal

1

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15 September 2017

Weerawat Runguphan

series ordinal

2

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15 September 2017

Kristala Jones Prather

series ordinal

4

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15 September 2017

publication date

1 May 2009

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15 September 2017

published in

Nature Chemical Biology

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15 September 2017

volume

5

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15 September 2017

issue

5

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15 September 2017

page(s)

292-300

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Natural compounds: leads or ideas? Bioinspired molecules for drug discovery

15 September 2017

cites work

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Alkaloid Biosynthesis[mdash]The Basis for Metabolic Engineering of Medicinal Plants

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12 December 2020

Quantification of metabolites in the indole alkaloid pathways of catharanthus roseus: implications for metabolic engineering

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Expression of a feedback-resistant anthranilate synthase in Catharanthus roseus hairy roots provides evidence for tight regulation of terpenoid indole alkaloid levels

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Opium alkaloid noscapine is an antitumor agent that arrests metaphase and induces apoptosis in dividing cells

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Metabolic engineering of the indole pathway in Catharanthus roseus hairy roots and increased accumulation of tryptamine and serpentine.

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12 December 2020

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Engineering Escherichia coli for production of functionalized terpenoids using plant P450s

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12 December 2020

Gene-to-metabolite networks for terpenoid indole alkaloid biosynthesis in Catharanthus roseus cells

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Quantitative 1H nuclear magnetic resonance metabolite profiling as a functional genomics platform to investigate alkaloid biosynthesis in opium poppy

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Environmental or developmental changes cause many enzyme activities of higher plants to rise or fall.

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Methyl jasmonate-induced overproduction of paclitaxel and baccatin III in Taxus cell suspension cultures

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Plant 'hairy root' culture

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Chemistry and biology of monoterpene indole alkaloid biosynthesis

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The evolving role of natural products in drug discovery

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Glossary of terms used in combinatorial chemistry (technical report).

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Structure-based engineering of strictosidine synthase: auxiliary for alkaloid libraries

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Understanding flux in plant metabolic networks

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RNAi-mediated replacement of morphine with the nonnarcotic alkaloid reticuline in opium poppy

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Unintended effects in genetically modified crops: revealed by metabolomics?

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The structure of Rauvolfia serpentina strictosidine synthase is a novel six-bladed beta-propeller fold in plant proteins

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Transcription factors: tools to engineer the production of pharmacologically active plant metabolites

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Transcriptional response of the terpenoid indole alkaloid pathway to the overexpression of ORCA3 along with jasmonic acid elicitation of Catharanthus roseus hairy roots over time.

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12 December 2020

Producing decaffeinated coffee plants

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Directed biosynthesis of alkaloid analogs in the medicinal plant Catharanthus roseus

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Stereocontrolled total synthesis of (+)-vinblastine

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Caffeine production in tobacco plants by simultaneous expression of three coffee N-methyltrasferases and its potential as a pest repellant

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The cell and developmental biology of alkaloid biosynthesis

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Engineering of artificial plant cytochrome P450 enzymes for synthesis of isoflavones by Escherichia coli

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Synthesis of (+)-vinblastine and its analogues

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Metabolic engineering of medicinal plants: transgenic Atropa belladonna with an improved alkaloid composition

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A novel jasmonate- and elicitor-responsive element in the periwinkle secondary metabolite biosynthetic gene Str interacts with a jasmonate- and elicitor-inducible AP2-domain transcription factor, ORCA2.

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Quantification of metabolic flux in plant secondary metabolism by a biogenetic organizational approach

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Effects of over-expression of strictosidine synthase and tryptophan decarboxylase on alkaloid production by cell cultures of Catharanthus roseus.

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Production of benzylisoquinoline alkaloids in Saccharomyces cerevisiae

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Opium poppy and Madagascar periwinkle: model non-model systems to investigate alkaloid biosynthesis in plants

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12 December 2020

Engineering of promoter replacement cassettes for fine-tuning of gene expression in Saccharomyces cerevisiae

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Metabolic reprogramming of periwinkle plant culture

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Engineering tropane biosynthetic pathway in Hyoscyamus niger hairy root cultures

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Production and engineering of terpenoids in plant cell culture

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Multicellular compartmentation of catharanthus roseus alkaloid biosynthesis predicts intercellular translocation of a pathway intermediate

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Effect of precursor feeding on alkaloid accumulation by a tryptophan decarboxylase over-expressing transgenic cell line T22 of Catharanthus roseus

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Stereocontrolled total synthesis of (+)-vincristine

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Substrate specificity of strictosidine synthase

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12 December 2020

Increasing morphinan alkaloid production by over-expressing codeinone reductase in transgenic Papaver somniferum

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12 December 2020

Flux quantification in central carbon metabolism of Catharanthus roseus hairy roots by 13C labeling and comprehensive bondomer balancing.

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12 December 2020

Biotransformation of tryptamine and secologanin into plant terpenoid indole alkaloids by transgenic yeast.

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12 December 2020

Ethylene induced shikonin biosynthesis in shoot culture of Lithospermum erythrorhizon

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12 December 2020

Methods for drug discovery: development of potent, selective, orally effective cholecystokinin antagonists

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Nicotine Biosynthetic Enzyme Activities in Nicotiana tabacum L. Genotypes with Different Alkaloid Levels

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Metabolic engineering with a morphine biosynthetic P450 in opium poppy surpasses breeding

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Plant-derived secondary metabolites as defensive chemicals in herbivorous insects: a case study in chemical ecology

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12 December 2020

Strictosidine synthase: mechanism of a Pictet-Spengler catalyzing enzyme

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Natural products as sources of new drugs over the last 25 years

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Analysis of yohimbine alkaloid from Pausinystalia yohimbe by non-aqueous capillary electrophoresis and gas chromatography-mass spectrometry

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12 December 2020

Rubisco without the Calvin cycle improves the carbon efficiency of developing green seeds.

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12 December 2020

Expression of deacetylvindoline-4-O-acetyltransferase in Catharanthus roseus hairy roots.

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12 December 2020

Evolutionary and cellular webs in benzylisoquinoline alkaloid biosynthesis.

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12 December 2020

Metabolic engineering of plant alkaloid biosynthesis

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12 December 2020

Determination of metabolic rate-limitations by precursor feeding in Catharanthus roseus hairy root cultures

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12 December 2020

Influence of Precursor Availability on Alkaloid Accumulation by Transgenic Cell Line of Catharanthus roseus

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12 December 2020

Taxus spp. needles contain amounts of taxol comparable to the bark of Taxus brevifolia: analysis and isolation

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Application of functional genomics to pathway optimization for increased isoprenoid production.

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12 December 2020

ORCA3, a jasmonate-responsive transcriptional regulator of plant primary and secondary metabolism

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12 December 2020

Light activation of vindoline biosynthesis does not require cytomorphogenesis in Catharanthus roseus seedlings

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12 December 2020

Production of indole alkaloids by selected hairy root lines ofCatharanthus roseus

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12 December 2020

Engineering the plant cell factory for secondary metabolite production

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12 December 2020

Redesign of a central enzyme in alkaloid biosynthesis.

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12 December 2020

Microbial production of plant benzylisoquinoline alkaloids

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12 December 2020

Rapid identification of enzyme variants for reengineered alkaloid biosynthesis in periwinkle

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12 December 2020

Why are secondary metabolites (natural products) biosynthesized?

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12 December 2020

Engineering yeast transcription machinery for improved ethanol tolerance and production.

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12 December 2020

Simultaneous determination of scopolamine, hyoscyamine and littorine in plants and different hairy root clones of Hyoscyamus muticus by micellar electrokinetic chromatography

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12 December 2020

Engineering central metabolic pathways for high-level flavonoid production in Escherichia coli

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12 December 2020

Privileged structures as leads in medicinal chemistry.

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12 December 2020

The combinatorial synthesis of bicyclic privileged structures or privileged substructures.

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12 December 2020

Expression of the Arabidopsis feedback-insensitive anthranilate synthase holoenzyme and tryptophan decarboxylase genes in Catharanthus roseus hairy roots.

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12 December 2020

Sol-gel chemistry in medicinal science.

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.160

7 January 2021

Alkaloid Studies. IX.1Rauwolfia Alkaloids. IV.2Isolation of Reserpine and Other Alkaloids from Rauwolfia sellowii Muell. Argov.3

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.160

7 January 2021

Genetic Control of the Caffeine Content of Coffee

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.160

7 January 2021

Quantitative analysis of alkaloids from Cinchona bark by high-performance liquid chromatography

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https://api.crossref.org/works/10.1038%2FNCHEMBIO.160

7 January 2021

Variation in vinblastine production by Catharanthus roseus, during in vivo and in vitro differentiation

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.160

7 January 2021

Identifiers

DOI

10.1038/NCHEMBIO.160

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Dimensions Publication ID

15 September 2017

1017938264

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