Simvastatin induces osteogenic differentiation of murine embryonic stem cells (Q39861887)

15 September 2017

title

Simvastatin induces osteogenic differentiation of murine embryonic stem cells (English)

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15 September 2017

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Joseph Pagkalos

1

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15 September 2017

Jae Min Cha

2

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15 September 2017

Yunyi Kang

3

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15 September 2017

Manolis Heliotis

4

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15 September 2017

Eleftherios Tsiridis

5

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15 September 2017

Athanasios Mantalaris

6

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15 September 2017

publication date

1 November 2010

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Journal of Bone and Mineral Research

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published in

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volume

25

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issue

11

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15 September 2017

page(s)

2470-2478

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Regulation of the mevalonate pathway

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cites work

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Effects of statins on bone mineral density: a meta-analysis of clinical studies

21 January 2018

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Simvastatin locally applied from a biodegradable coating of osteosynthetic implants improves fracture healing comparable to BMP-2 application

21 January 2018

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Compactin and simvastatin, but not pravastatin, induce bone morphogenetic protein-2 in human osteosarcoma cells

21 January 2018

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Simvastatin and atorvastatin enhance gene expression of collagen type 1 and osteocalcin in primary human osteoblasts and MG-63 cultures

21 January 2018

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Simvastatin, an HMG-CoA reductase inhibitor, reduced the expression of matrix metalloproteinase-9 (Gelatinase B) in osteoblastic cells and HT1080 fibrosarcoma cells

21 January 2018

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Calcyclin, a Ca2+ ion-binding protein, contributes to the anabolic effects of simvastatin on bone.

21 January 2018

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Induction of osteoblast differentiation indices by statins in MC3T3-E1 cells

21 January 2018

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The effect of simvastatin on the proliferation and differentiation of human bone marrow stromal cells

21 January 2018

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Lovastatin inhibits adipogenic and stimulates osteogenic differentiation by suppressing PPARγ2 and increasing Cbfa1/Runx2 expression in bone marrow mesenchymal cell cultures

21 January 2018

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Simvastatin induces osteoblastic differentiation and inhibits adipocytic differentiation in mouse bone marrow stromal cells

21 January 2018

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Synthesis and characterization of a fluvastatin-releasing hydrogel delivery system to modulate hMSC differentiation and function for bone regeneration.

21 January 2018

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Compactin enhances osteogenesis in murine embryonic stem cells.

21 January 2018

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Stimulation of bone formation in vitro and in rodents by statins

21 January 2018

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Quantitative measures of femoral fracture repair in rats derived by micro-computed tomography

21 January 2018

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Locally applied Simvastatin improves fracture healing in mice

21 January 2018

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Simvastatin improves fracture healing in mice

21 January 2018

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Early healing pattern of statin-induced osteogenesis.

21 January 2018

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Effects of simvastatin on bone turnover and BMD: a 1-year randomized controlled trial in postmenopausal osteopenic women

21 January 2018

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Prospective, double blind, randomized, controlled trial of simvastatin in human fracture healing

21 January 2018

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ML-236A, ML-236B, and ML-236C, new inhibitors of cholesterogenesis produced by Penicillium citrinium

21 January 2018

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Relative Lipophilicities, Solubilities, and Structure–Pharmacological Considerations of 3-Hydroxy-3-Methylglutaryl-Coenzyme A (HMG-CoA) Reductase Inhibitors Pravastatin, Lovastatin, Mevastatin, and Simvastatin

21 January 2018

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Statins (HMG-coenzyme A reductase inhibitors)-biomimetic membrane binding mechanism investigated by molecular chromatography

21 January 2018

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In vitro direct chondrogenesis of murine embryonic stem cells by bypassing embryoid body formation

21 January 2018

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In vitro direct osteogenesis of murine embryonic stem cells without embryoid body formation

21 January 2018

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Differentiation of human embryonic stem cells to cardiomyocytes: role of coculture with visceral endoderm-like cells

21 January 2018

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Enhanced derivation of osteogenic cells from murine embryonic stem cells after treatment with HepG2-conditioned medium and modulation of the embryoid body formation period: application to skeletal tissue engineering

21 January 2018

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Integrated 3-dimensional expansion and osteogenic differentiation of murine embryonic stem cells

21 January 2018

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An Alizarin red-based assay of mineralization by adherent cells in culture: comparison with cetylpyridinium chloride extraction

21 January 2018

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Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

21 January 2018

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New insights into the pharmacodynamic and pharmacokinetic properties of statins.

21 January 2018

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Differentiation of osteoblasts and in vitro bone formation from murine embryonic stem cells

21 January 2018

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Hydrophilicity/lipophilicity: relevance for the pharmacology and clinical effects of HMG-CoA reductase inhibitors

21 January 2018

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Simvastatin promotes osteoblast differentiation and mineralization in MC3T3-E1 cells

21 January 2018

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Atorvastatin stimulates the production of osteoprotegerin by human osteoblasts.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/JBMR.163

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15 September 2017

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