Biomechanical modulation of collagen fragment-induced anabolic and catabolic activities in chondrocyte/agarose constructs (Q39874097)

15 September 2017

Biomechanical modulation of collagen fragment-induced anabolic and catabolic activities in chondrocyte/agarose constructs (English)

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15 September 2017

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Tina T Chowdhury

1

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15 September 2017

Ronny M Schulz

2

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15 September 2017

Sonpreet S Rai

3

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15 September 2017

Christian B Thuemmler

4

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15 September 2017

Nico Wuestneck

5

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15 September 2017

Augustinus Bader

6

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15 September 2017

Gene A Homandberg

7

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15 September 2017

language of work or name

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12 May 2010

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Arthritis Research and Therapy

15 September 2017

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15 September 2017

12

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15 September 2017

3

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15 September 2017

R82

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https://scigraph.springernature.com/pub.10.1186/ar3009

15 September 2017

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cites work

Signalling cascades in mechanotransduction: cell-matrix interactions and mechanical loading.

1 reference

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The futility of current approaches to chondroprotection

22 September 2017

1 reference

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Mechanical regulation of matrix metalloproteinases.

22 September 2017

1 reference

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Cartilage destruction by matrix degradation products

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911866

The role of mechanical loading in the onset and progression of osteoarthritis

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911866

NF-kappa B mediates the stimulation of cytokine and chemokine expression by human articular chondrocytes in response to fibronectin fragments

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911866

Altered patterns and synthesis of extracellular matrix macromolecules in early osteoarthritis

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911866

Mechanical loading of chondrocytes embedded in 3D constructs: in vitro methods for assessment of morphological and metabolic response to compressive strain.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911866

The role of biomechanics and inflammation in cartilage injury and repair.

22 September 2017

1 reference

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Integrin-dependent signal cascades in chondrocyte mechanotransduction

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911866

Mechanical compression of cartilage explants induces multiple time-dependent gene expression patterns and involves intracellular calcium and cyclic AMP

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911866

The role of reactive oxygen species in homeostasis and degradation of cartilage

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911866

The effect of cyclical compressive loading on gene expression in articular cartilage.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911866

Relative expression software tool (REST©) for group-wise comparison and statistical analysis of relative expression results in real-time PCR

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911866

Potential regulation of cartilage metabolism in osteoarthritis by fibronectin fragments

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911866

Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911866

An immunohistochemical study of fibronectin in human osteoarthritic and disease free articular cartilage

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911866

Fibronectin-fragment-induced cartilage chondrolysis is associated with release of catabolic cytokines

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911866

Sites of stromelysin cleavage in collagen types II, IX, X, and XI of cartilage.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911866

Quantification of mRNA using real-time PCR and Western blot analysis of MAPK events in chondrocyte/agarose constructs.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911866

Catabolic responses of chondrocyte-seeded peptide hydrogel to dynamic compression

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911866

Fibronectin fragments mediate matrix metalloproteinase upregulation and cartilage damage through proline rich tyrosine kinase 2, c-src, NF-kappaB and protein kinase Cdelta.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911866

Telopeptides of type II collagen upregulate proteinases and damage cartilage but are less effective than highly active fibronectin fragments

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911866

Development and validation of a novel bioreactor system for load- and perfusion-controlled tissue engineering of chondrocyte-constructs

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911866

Dynamic compression inhibits fibronectin fragment induced iNOS and COX-2 expression in chondrocyte/agarose constructs

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911866

Cyclic compressive mechanical stimulation induces sequential catabolic and anabolic gene changes in chondrocytes resulting in increased extracellular matrix accumulation.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911866

Molecular mechanisms of cartilage destruction: mechanics, inflammatory mediators, and aging collide

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911866

A single application of cyclic loading can accelerate matrix deposition and enhance the properties of tissue-engineered cartilage.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911866

Fibronectin fragments elevate nitric oxide (NO) and inducible NO synthetase (iNOS) levels in bovine cartilage and iNOS inhibitors block fibronectin fragment mediated damage and promote repair

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911866

COOH-terminal heparin-binding fibronectin fragment induces nitric oxide production in rheumatoid cartilage through CD44.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911866

Effects of dynamic compressive loading on chondrocyte biosynthesis in self-assembling peptide scaffolds

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911866

Influence of tissue maturation and antioxidants on the apoptotic response of articular cartilage after injurious compression

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911866

N-telopeptide of type II collagen interacts with annexin V on human chondrocytes

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911866

Synergistic action of growth factors and dynamic loading for articular cartilage tissue engineering.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911866

Dynamic compression counteracts IL-1 beta-induced release of nitric oxide and PGE2 by superficial zone chondrocytes cultured in agarose constructs

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911866

Temporal regulation of chondrocyte metabolism in agarose constructs subjected to dynamic compression

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911866

Fibronectin fragments and blocking antibodies to alpha2beta1 and alpha5beta1 integrins stimulate mitogen-activated protein kinase signaling and increase collagenase 3 (matrix metalloproteinase 13) production by human articular chondrocytes

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911866

Antisense oligonucleotides to the integrin receptor subunit alpha(5) decrease fibronectin fragment mediated cartilage chondrolysis

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911866

Focal adhesion kinase and mitogen-activated protein kinases are involved in chondrocyte activation by the 29-kDa amino-terminal fibronectin fragment

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911866

Dynamic compression inhibits the synthesis of nitric oxide and PGE(2) by IL-1beta-stimulated chondrocytes cultured in agarose constructs

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911866

Disease modification in osteoarthritis: Are drugs the answer?

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2911866

Uncoupling of type II collagen synthesis and degradation predicts progression of joint damage in patients with knee osteoarthritis

2 December 2018

1 reference

12 December 2020

Time, stress, and location dependent chondrocyte death and collagen damage in cyclically loaded articular cartilage

1 reference

12 December 2020

Increased urinary concentration of collagen type II C-telopeptide fragments in patients with osteoarthritis

1 reference

12 December 2020

Down-regulation of chondrocyte aggrecan and type-II collagen gene expression correlates with increases in static compression magnitude and duration

1 reference

12 December 2020

Mechanical and physicochemical regulation of the action of insulin-like growth factor-I on articular cartilage

1 reference

12 December 2020

The effects of collagen fragments on the extracellular matrix metabolism of bovine and human chondrocytes

1 reference

12 December 2020

Characterization of synovial fluid fibronectin from patients with rheumatic inflammatory diseases and healthy subjects

1 reference

12 December 2020

Fibronectin fragments cause chondrolysis of bovine articular cartilage slices in culture

1 reference

12 December 2020

Fibronectin fragments in osteoarthritic synovial fluid

1 reference

12 December 2020

Fibronectin fragments alter matrix protein synthesis in cartilage tissue cultured in vitro.

1 reference

12 December 2020

Cartilage chondrolysis by fibronectin fragments is associated with release of several proteinases: stromelysin plays a major role in chondrolysis

1 reference

12 December 2020

Association of proteoglycan degradation with catabolic cytokine and stromelysin release from cartilage cultured with fibronectin fragments

1 reference

12 December 2020

Matrix loss and synthesis following a single impact load on articular cartilage in vitro

1 reference

12 December 2020

Compressive strains at physiological frequencies influence the metabolism of chondrocytes seeded in agarose

1 reference

12 December 2020

Load-controlled compression of articular cartilage induces a transient stimulation of aggrecan gene expression

1 reference

12 December 2020

Cartilage damaging activities of fibronectin fragments derived from cartilage and synovial fluid

1 reference

12 December 2020

The effect of continuously applied cyclic mechanical loading on the fibronectin metabolism of articular cartilage explants

1 reference

12 December 2020

Type II collagen peptide release from rabbit articular cartilage

1 reference

12 December 2020

Cyclic compression of articular cartilage explants is associated with progressive consolidation and altered expression pattern of extracellular matrix proteins

1 reference

12 December 2020

Collagen degradation products modulate matrix metalloproteinase expression in cultured articular chondrocytes

1 reference

12 December 2020

FGF-2 is bound to perlecan in the pericellular matrix of articular cartilage, where it acts as a chondrocyte mechanotransducer

1 reference

12 December 2020

A critical role for collagen II in cartilage matrix degradation: collagen II induces pro-inflammatory cytokines and MMPs in primary human chondrocytes

1 reference

12 December 2020

Identifiers

DOI

10.1186/AR3009

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Dimensions Publication ID

15 September 2017

0 references

1 reference

15 September 2017

PubMed publication ID

20462435

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