The lysosome among targets of metformin: new anti-inflammatory uses for an old drug? (Q39882878)

15 September 2017

The lysosome among targets of metformin: new anti-inflammatory uses for an old drug? (English)

1 reference

15 September 2017

0 references

1 reference

Thomas D Lockwood

1

1 reference

PubMed ID

20392164

15 September 2017

language of work or name

English

0 references

publication date

1 May 2010

1 reference

Expert Opinion on Therapeutic Targets

15 September 2017

1 reference

15 September 2017

14

1 reference

15 September 2017

5

1 reference

15 September 2017

467-478

1 reference

Gamma-IFN-inducible-lysosomal thiol reductase modulates acidic proteases and HLA class II antigen processing in melanoma

15 September 2017

1 reference

https://api.crossref.org/works/10.1517%2F14728221003774135

New concepts in antimalarial use and mode of action in dermatology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003774135

Clinical efficacy and side effects of antimalarials in systemic lupus erythematosus: a systematic review

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003774135

Protein degradation in cultured cells. II. The uptake of chloroquine by rat fibroblasts and the inhibition of cellular protein degradation and cathepsin B1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003774135

Chloroquine blood concentrations and molecular markers of chloroquine-resistant Plasmodium falciparum in febrile children in northern Ghana

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003774135

Hydroxychloroquine for the prevention of acute graft-versus-host disease after unrelated donor transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003774135

The known unknowns of antigen processing and presentation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003774135

Hypoglycaemia induced by hydroxychloroquine in a non-diabetic patient treated for RA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003774135

The effectiveness of hydroxychloroquine in patients with type 2 diabetes mellitus who are refractory to sulfonylureas--a randomized trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003774135

Biochemical characterization of ADP-ribose polymer metabolism in SLE.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003774135

Effects of chloroquine on the dyslipidemia of non-insulin-dependent diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003774135

Diabetes and rheumatic diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003774135

Cardiovascular risk in rheumatoid arthritis: effects of anti-TNF drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003774135

The implication of proinflammatory cytokines in type 2 diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003774135

Adipose tissue macrophages, low grade inflammation and insulin resistance in human obesity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003774135

Autophagy and acute pancreatitis: a novel autophagy theory for trypsinogen activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003774135

Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003774135

Hydroxychloroquine and risk of diabetes in patients with rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003774135

Potential role of TNF-alpha in the pathogenesis of insulin resistance and type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003774135

The role of TNF-alpha in chronic inflammatory conditions, intermediary metabolism, and cardiovascular risk

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003774135

Cathepsin B knockout mice are resistant to tumor necrosis factor-alpha-mediated hepatocyte apoptosis and liver injury: implications for therapeutic applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003774135

Metformin therapy and clinical uses

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003774135

Oral antidiabetic agents: anti-atherosclerotic properties beyond glucose lowering?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003774135

Colloidal metallic gold is not bio-inert

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003774135

Metal compounds for the treatment of parasitic diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003774135

Inhibition of cathepsin B by Au(I) complexes: a kinetic and computational study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003774135

Antidiabetic and antimalarial biguanide drugs are metal-interactive antiproteolytic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003774135

Cys-His proteases are among the wired proteins of the cell

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003774135

Acute Metformin Overdose: Examining Serum pH, Lactate Level, and Metformin Concentrations in Survivors Versus Nonsurvivors: A Systematic Review of the Literature

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003774135

Albumin as a zinc carrier: properties of its high-affinity zinc-binding site.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003774135

Inhibitors of cathepsin B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003774135

Signaling pathways involved in human vascular smooth muscle cell proliferation and matrix metalloproteinase-2 expression induced by leptin: inhibitory effect of metformin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003774135

Cathepsin B is involved in the trafficking of TNF-alpha-containing vesicles to the plasma membrane in macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003774135

Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003774135

Cathepsin L is essential for onset of autoimmune diabetes in NOD mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003774135

Autophagy in human type 2 diabetes pancreatic beta cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003774135

Death receptor 5 internalization is required for lysosomal permeabilization by TRAIL in malignant liver cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003774135

The cathepsin B death pathway contributes to TNF plus IFN-gamma-mediated human endothelial injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003774135

Lipopolysaccharide can trigger a cathepsin B-dependent programmed death response in human endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003774135

Direct measurement of cathepsin B activity in the cytosol of apoptotic cells by an activity-based probe

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003774135

Tumor necrosis factor induces the loss of sphingosine kinase-1 by a cathepsin B-dependent mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003774135

Role of cathepsin B-mediated apoptosis in fulminant hepatic failure in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003774135

Cystatins: biochemical and structural properties, and medical relevance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003774135

Molecular background of EPM1-Unverricht-Lundborg disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003774135

Seizures, ataxia, and neuronal loss in cystatin B heterozygous mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003774135

Analysis of metal-binding proteins separated by non-denaturating gel electrophoresis using matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) and laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003774135

Autocatalytic processing of procathepsin B is triggered by proenzyme activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003774135

Displacement of the occluding loop by the parasite protein, chagasin, results in efficient inhibition of human cathepsin B

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003774135

Mammalian zinc transport, trafficking, and signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003774135

Zinc fluxes and zinc transporter genes in chronic diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003774135

Intracellular zinc homeostasis and zinc signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003774135

The ligand environment of zinc stored in vesicles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003774135

The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003774135

Chloroquine extends the lifetime of the activated insulin receptor complex in endosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003774135

In Vivo Chloroquine-induced Inhibition of Insulin Degradation in a Diabetic Patient with Severe Insulin Resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003774135

The pharmacology of the insulinomimetic effect of zinc complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003774135

Insulin-sparing effect of hydroxychloroquine in diabetic rats is concentration dependent

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003774135

An expedient and facile one-step synthesis of a biguanide library by microwave irradiation coupled with simple product filtration. Inhibitors of dihydrofolate reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003774135

Cathepsin B inhibition prevents trypsinogen activation and reduces pancreatitis severity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728221003774135

10.1517/14728221003774135

21 January 2018

Identifiers

DOI

1 reference

15 September 2017

1 reference

PubMed ID

20392164