Significant correction of pathology in brains of twitcher mice following injection of genetically modified mouse neural progenitor cells (Q39883889)

15 September 2017

Significant correction of pathology in brains of twitcher mice following injection of genetically modified mouse neural progenitor cells (English)

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15 September 2017

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Michelina Strazza

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15 September 2017

Alice Luddi

2

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15 September 2017

Marica Carbone

3

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15 September 2017

Mohammad A Rafi

4

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15 September 2017

Elvira Costantino-Ceccarini

5

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15 September 2017

David A Wenger

6

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15 September 2017

12 February 2009

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Molecular Genetics and Metabolism

15 September 2017

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15 September 2017

97

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1

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27-34

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An apoptotic depletion of oligodendrocytes in the twitcher, a murine model of globoid cell leukodystrophy.

15 September 2017

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https://api.crossref.org/works/10.1016%2FJ.YMGME.2009.01.005

Apoptotic positive cells in Krabbe brain and induction of apoptosis in rat C6 glial cells by psychosine

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMGME.2009.01.005

Psychosine is as potent an inducer of cell death as C6-ceramide in cultured fibroblasts and in MOCH-1 cells

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMGME.2009.01.005

Psychosine-induced apoptosis in a mouse oligodendrocyte progenitor cell line is mediated by caspase activation

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMGME.2009.01.005

Insulin-like growth factor-1 provides protection against psychosine-induced apoptosis in cultured mouse oligodendrocyte progenitor cells using primarily the PI3K/Akt pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2009.01.005

Hematopoietic stem-cell transplantation in globoid-cell leukodystrophy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2009.01.005

Transplantation of umbilical-cord blood in babies with infantile Krabbe's disease

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMGME.2009.01.005

The Twitcher mouse: an enzymatically authentic model of human globoid cell leukodystrophy (Krabbe disease)

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2009.01.005

Generation of a mouse with low galactocerebrosidase activity by gene targeting: a new model of globoid cell leukodystrophy (Krabbe disease).

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2009.01.005

Prolonged survival and remyelination after hematopoietic cell transplantation in the twitcher mouse.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMGME.2009.01.005

Hematopoietic cell transplantation in murine globoid cell leukodystrophy (the twitcher mouse): effects on levels of galactosylceramidase, psychosine, and galactocerebrosides

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2009.01.005

Effect of bone marrow transplantation on enzyme levels and clinical course in the neurologically affected twitcher mouse

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMGME.2009.01.005

Biochemical and pathological evaluation of long-lived mice with globoid cell leukodystrophy after bone marrow transplantation

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMGME.2009.01.005

Cloning and expression of cDNA encoding human galactocerebrosidase, the enzyme deficient in globoid cell leukodystrophy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2009.01.005

Retroviral vector-mediated transfer of the galactocerebrosidase (GALC) cDNA leads to overexpression and transfer of GALC activity to neighboring cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2009.01.005

Correction of the galactocerebrosidase deficiency in globoid cell leukodystrophy-cultured cells by SL3-3 retroviral-mediated gene transfer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2009.01.005

Retroviral-mediated transfer of the galactocerebrosidase gene in neural progenitor cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2009.01.005

Transduction of cultured oligodendrocytes from normal and twitcher mice by a retroviral vector containing human galactocerebrosidase (GALC) cDNA.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2009.01.005

Retrovirus-mediated gene transfer and galactocerebrosidase uptake into twitcher glial cells results in appropriate localization and phenotype correction

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2009.01.005

Intraventricular administration of recombinant adenovirus to neonatal twitcher mouse leads to clinicopathological improvements

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMGME.2009.01.005

GALC transduction leads to morphological improvement of the twitcher oligodendrocytes in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2009.01.005

Transgenic rescue of Krabbe disease in the twitcher mouse

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2009.01.005

AAV-mediated expression of galactocerebrosidase in brain results in attenuated symptoms and extended life span in murine models of globoid cell leukodystrophy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2009.01.005

AAV2/5 vector expressing galactocerebrosidase ameliorates CNS disease in the murine model of globoid-cell leukodystrophy more efficiently than AAV2.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2009.01.005

Design and optimization of lentiviral vectors for transfer of GALC expression in Twitcher brain.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2009.01.005

Central nervous system-directed AAV2/5-mediated gene therapy synergizes with bone marrow transplantation in the murine model of globoid-cell leukodystrophy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2009.01.005

Widespread engraftment of neural progenitor and stem-like cells throughout the mouse brain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2009.01.005

Galactocerebrosidase-deficient oligodendrocytes maintain stable central myelin by exogenous replacement of the missing enzyme in mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2009.01.005

Enzyme replacement therapy results in substantial improvements in early clinical phenotype in a mouse model of globoid cell leukodystrophy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2009.01.005

Safe and efficient generation of recombinant retroviruses with amphotropic and ecotropic host ranges

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2009.01.005

A Stable Bovine Papillomavirus Hybrid Plasmid That Expresses a Dominant Selective Trait

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2009.01.005

Analysis of galactocerebrosidase activity in the mouse brain by a new histological staining method.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2009.01.005

Glial progenitors in the CNS and possible lineage relationships among them

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMGME.2009.01.005

Mapping spatio-temporal activation of Notch signaling during neurogenesis and gliogenesis in the developing mouse brain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2009.01.005

Stem cells for the treatment of neurological disorders

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMGME.2009.01.005

10.1016/J.YMGME.2009.01.005

7 January 2021

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15 September 2017

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