Intranasal delivery--modification of drug metabolism and brain disposition (Q39885234)

15 September 2017

Intranasal delivery--modification of drug metabolism and brain disposition (English)

1 reference

15 September 2017

Yin Cheong Wong

1

0 references

author name string

Zhong Zuo

series ordinal

2

1 reference

15 September 2017

6 April 2010

1 reference

15 September 2017

Pharmaceutical Research

1 reference

15 September 2017

27

1 reference

15 September 2017

7

1 reference

15 September 2017

1208-1223

1 reference

Drug transport into the mammalian brain: the nasal pathway and its specific metabolic barrier

15 September 2017

1 reference

https://api.crossref.org/works/10.1007%2FS11095-010-0127-5

Metabolic capacity of nasal tissue interspecies comparisons of xenobiotic-metabolizing enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-010-0127-5

Metabolism of ciclesonide in the upper and lower airways: review of available data

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-010-0127-5

Pharmacokinetics and pharmacodynamics of intranasal "snorted" heroin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-010-0127-5

Pharmacokinetics and pharmacodynamics of cocaine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-010-0127-5

Ketamine and norketamine plasma concentrations after i.v., nasal and rectal administration in children.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-010-0127-5

Pharmacokinetics of midazolam given as an intranasal spray to adult surgical patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-010-0127-5

Angiotensin-converting enzyme in the human nasal mucosa

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-010-0127-5

Specific aminopeptidases of excised human nasal epithelium and primary culture: a comparison of functional characteristics and gene transcripts expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-010-0127-5

Validation of excised bovine nasal mucosa as in vitro model to study drug transport and metabolic pathways in nasal epithelium

21 January 2018

1 reference

12 December 2020

Development of a human nasal epithelial cell culture model and its suitability for transport and metabolism studies under in vitro conditions

1 reference

12 December 2020

Nasal administration of opioids for pain management in adults

1 reference

12 December 2020

NASAL ADMINISTRATION OF MORPHINE-6-GLUCURONIDE IN SHEEP—A PHARMACOKINETIC STUDY

1 reference

12 December 2020

Intranasal drug delivery for brain targeting.

1 reference

12 December 2020

Morphine-3-glucuronide may functionally antagonize morphine-6-glucuronide induced antinociception and ventilatory depression in the rat

1 reference

12 December 2020

Beclomethasone dipropionate: absolute bioavailability, pharmacokinetics and metabolism following intravenous, oral, intranasal and inhaled administration in man

1 reference

12 December 2020

Species differences in diazepam metabolism—I. Metabolism of diazepam metabolites

1 reference

12 December 2020

Does Increasing the Lipophilicity of Peptides Enhance Their Nasal Absorption?

1 reference

12 December 2020

Can nasal drug delivery bypass the blood-brain barrier?: questioning the direct transport theory

1 reference

12 December 2020

Role of pharmacologically active metabolites in drug discovery and development

1 reference

12 December 2020

The clinical applications of intranasal opioids.

1 reference

12 December 2020

Functional evidence for P-glycoprotein at the nose-brain barrier.

1 reference

12 December 2020

Benzodiazepine concentrations in brain directly reflect receptor occupancy: studies of diazepam, lorazepam, and oxazepam

1 reference

12 December 2020

Systematic review of factors affecting the ratios of morphine and its major metabolites

1 reference

12 December 2020

Direct transport of cocaine from the nasal cavity to the brain following intranasal cocaine administration in rats.

1 reference

12 December 2020

Active metabolites of antidepressants: pharmacodynamics and relevant pharmacokinetics

1 reference

12 December 2020

Preliminary studies of the pharmacokinetics and tolerability of zolmitriptan nasal spray in healthy volunteers

1 reference

12 December 2020

Nasal mucociliary clearance as a factor in nasal drug delivery

1 reference

12 December 2020

Effects of intranasal corticosteroids on adrenal, bone, and blood markers of systemic activity in allergic rhinitis

1 reference

12 December 2020

Pharmacokinetics of ciclesonide and desisobutyryl ciclesonide after administration via aqueous nasal spray or hydrofluoroalkane nasal aerosol compared with orally inhaled ciclesonide: an open-label, single-dose, three-period crossover study in healt

1 reference

12 December 2020

Nasal mucoadhesive drug delivery: background, applications, trends and future perspectives

1 reference

12 December 2020

Pharmacokinetics of intranasal corticosteroids

1 reference

12 December 2020

Upper respiratory tract uptake of naphthalene

1 reference

12 December 2020

Intranasal delivery of morphine

1 reference

12 December 2020

Stability of PEGylated salmon calcitonin in nasal mucosa.

1 reference

12 December 2020

P-Glycoprotein attenuates brain uptake of substrates after nasal instillation.

1 reference

12 December 2020

Intranasal diamorphine as an alternative to intramuscular morphine: pharmacokinetic and pharmacodynamic aspects

1 reference

12 December 2020

Species difference in diazepam metabolism and anticonvulsant effect

1 reference

12 December 2020

The pharmacokinetics of butorphanol and its metabolites at steady state following nasal administration in humans

1 reference

12 December 2020

Plasma concentration profiles of ketamine and norketamine after administration of various ketamine preparations to healthy Japanese volunteers

1 reference

12 December 2020

Cocaethylene: pharmacology, physiology and behavioral effects in humans.

1 reference

12 December 2020

Complicating factors in safety testing of drug metabolites: kinetic differences between generated and preformed metabolites

1 reference

12 December 2020

A metabolic explantation for differences between species of the anticonvulsant activity of diazepam

1 reference

12 December 2020

Hydrolysis of peptides in the nasal cavity of humans

1 reference

12 December 2020

Evaluation of the degradation of desamino1,D-arginine8-vasopressin by nasal mucosa

1 reference

12 December 2020

Study of nasal enzyme activity towards insulin. In vitro

1 reference

12 December 2020

Metabolism and absorption enhancement of methionine enkephalin in human nasal epithelium

1 reference

12 December 2020

Bioequivalence and rapid absorption of zolmitriptan nasal spray compared with oral tablets in healthy Japanese subjects

1 reference

12 December 2020

Transport of drugs from the nasal cavity to the central nervous system

1 reference

12 December 2020

Drug metabolism in the nasal cavity: relevance to toxicology

1 reference

12 December 2020

Nasal absorption and pharmacokinetic disposition of salmon calcitonin modified with low molecular weight polyethylene glycol

1 reference

12 December 2020

Measures for detecting systemic bioactivity with inhaled and intranasal corticosteroids

1 reference

12 December 2020

Strain differences in diazepam metabolism at its three metabolic sites in sprague-dawley, brown norway, dark agouti, and wistar strain rats

1 reference

12 December 2020

Kinetic and dynamic study of intravenous lorazepam: comparison with intravenous diazepam.

1 reference

12 December 2020

Comparative localization of carboxylesterase in F344 rat, beagle dog, and human nasal tissue

1 reference

12 December 2020

Pharmacokinetics and pharmacokinetic variability of heroin and its metabolites: review of the literature

1 reference

12 December 2020

Active metabolites of neuroleptic drugs: possible contribution to therapeutic and toxic effects

1 reference

12 December 2020

Enhancement of the systemic and CNS specific delivery of L-dopa by the nasal administration of its water soluble prodrugs

1 reference

12 December 2020

Intranasal delivery to the central nervous system: mechanisms and experimental considerations

1 reference

12 December 2020

Evaluation of the contribution of the nasal cavity and gastrointestinal tract to drug absorption following nasal application to rats

1 reference

12 December 2020

Human nasal mucosal carboxypeptidase: activity, location, and release

1 reference

12 December 2020

Morphine-3-glucuronide--a potent antagonist of morphine analgesia

1 reference

12 December 2020

Nipecotic acid: systemic availability and brain delivery after nasal administration of nipecotic acid and n-butyl nipecotate to rats

1 reference

12 December 2020

Mechanism of nasal absorption of drugs. III: Nasal absorption of leucine enkephalin

1 reference

12 December 2020

Pharmacokinetics and pharmacodynamics of midazolam administered as a concentrated intranasal spray. A study in healthy volunteers

1 reference

12 December 2020

Effects of concentration and volume on nasal bioavailability and biological response to desmopressin

1 reference

12 December 2020

Nasal Cavity Enzymes Involved in Xenobiotic Metabolism: Effects on the Toxicity of Inhalants

1 reference

12 December 2020

Direct nose-to-brain transfer of morphine after nasal administration to rats

1 reference

12 December 2020

Direct transport of 2',3'-didehydro-3'-deoxythymidine (D4T) and its ester derivatives to the cerebrospinal fluid via the nasal mucous membrane in rats

1 reference

12 December 2020

Nasal epithelial permeation of thymotrinan (TP3) versus thymocartin (TP4): competitive metabolism and self-enhancement

1 reference

12 December 2020

Targeted brain delivery of 17 beta-estradiol via nasally administered water soluble prodrugs

1 reference

12 December 2020

Accumulation and turnover of metabolites of toluene and xylene in nasal mucosa and olfactory bulb in the mouse.

1 reference

12 December 2020

Plasma concentrations of heroin and morphine-related metabolites after intranasal and intramuscular administration

1 reference

12 December 2020

Role of active metabolites in the use of opioids

1 reference

12 December 2020

Pharmacokinetics of substrate uptake and distribution in murine brain after nasal instillation

1 reference

12 December 2020

Enkephalin hydrolysis in homogenates of various absorptive mucosae of the albino rabbit: similarities in rates and involvement of aminopeptidases

1 reference

12 December 2020

Use of biomarkers and surrogate endpoints in drug development and regulatory decision making: criteria, validation, strategies

1 reference

12 December 2020

Recent patents review on intranasal administration for CNS drug delivery

1 reference

12 December 2020

Human nasal mucosal neutral endopeptidase (NEP): location, quantitation, and secretion

1 reference

12 December 2020

Prodrugs for nasal drug delivery

1 reference

12 December 2020

Nasal mucosal versus gastrointestinal absorption of nasally administered cocaine

1 reference

12 December 2020

Xenobiotic-metabolizing enzymes in human respiratory nasal mucosa

1 reference

12 December 2020

Nasal drug delivery--possibilities, problems and solutions

1 reference

12 December 2020

Diazepam metabolism in the kidneys of male and female rats of various strains

1 reference

12 December 2020

Progress in drug delivery to the central nervous system by the prodrug approach.

1 reference

12 December 2020

Intranasal administration of peptides: nasal deposition, biological response, and absorption of desmopressin

1 reference

12 December 2020

Regional differences in bioavailability of an opioid tetrapeptide in vivo in rats after administration to the respiratory tract

1 reference

12 December 2020

Pharmacokinetic comparison of intravenous and intranasal administration of oxycodone.

1 reference

12 December 2020

Characterization of human nasal primary culture systems to investigate peptide metabolism

1 reference

12 December 2020

[Kinetics of Semax penetration into the brain and blood of rats after its intranasal administration]

1 reference

12 December 2020

Active drug metabolites in drug development

1 reference

12 December 2020

Aminopeptidase activity in human nasal mucosa.

1 reference

12 December 2020

Mechanistic appraisal of the effects of some protease inhibitors on ciliary beat frequency in a sequential cell culture system of human nasal epithelium

1 reference

12 December 2020

Metabolism of diethylnitrosamine by microsomes of human respiratory nasal mucosa and liver

1 reference

12 December 2020

The pharmacology of PEGylation: balancing PD with PK to generate novel therapeutics

1 reference

12 December 2020

Nasal mucosal metabolism and absorption of pentapeptide enkephalin analogs having varying N-terminal amino acids

1 reference

12 December 2020

Nasal absorption enhancement strategies for therapeutic peptides: an in vitro study using cultured human nasal epithelium

1 reference

12 December 2020

Discovering drugs through biological transformation: role of pharmacologically active metabolites in drug discovery

1 reference

12 December 2020

Morphine-6-glucuronide: actions and mechanisms

1 reference

12 December 2020

Disposition of parenteral butorphanol in man

1 reference

12 December 2020

A review of the preclinical and clinical data of newer intranasal steroids used in the treatment of allergic rhinitis

1 reference

12 December 2020

Characterization of microsomal cytochrome P450-dependent monooxygenases in the rat olfactory mucosa.

1 reference

12 December 2020

Nasal delivery of peptides: an in vitro cell culture model for the investigation of transport and metabolism in human nasal epithelium

1 reference

12 December 2020

Hydrolysis of leucine enkephalin in the nasal cavity of the rat--a possible factor in the low bioavailability of nasally administered peptides

1 reference

12 December 2020

Mechanism of nasal absorption of drugs. II: Absorption of L-tyrosine and the effect of structural modification on its absorption

1 reference

12 December 2020

In vitro metabolism of ciclesonide in human nasal epithelial cells

1 reference

12 December 2020

Pharmacokinetic evaluation and modeling of formulated levodopa intranasal delivery systems

1 reference

12 December 2020

Formed and preformed metabolites: facts and comparisons.

1 reference

12 December 2020

High-affinity nasal extraction of vinyl acetate vapor is carboxylesterase dependent.

1 reference

12 December 2020

Degradation of [mercaptopropionic acid1, D-arginine8]-vasopressin (dDAVP) in pancreatic juice and intestinal mucosa homogenate

1 reference

12 December 2020

Characterization of the pharmacodynamic interaction between parent drug and active metabolite in vivo: midazolam and alpha-OH-midazolam.

1 reference

12 December 2020

Pharmacokinetics and brain uptake of diazepam after intravenous and intranasal administration in rats and rabbits

1 reference

12 December 2020

Metabolites and safety: What are the concerns, and how should we address them?

1 reference

12 December 2020

Disposition of nasal, intravenous, and oral methadone in healthy volunteers

1 reference

12 December 2020

Direct nose-brain transport of benzoylecgonine following intranasal administration in rats

1 reference

12 December 2020

Recovery of rat nasal mucosa from the effects of aminopeptidase inhibitors

1 reference

12 December 2020

10.1007/S11095-010-0127-5

Identifiers

DOI

1 reference

15 September 2017

1 reference

PubMed ID

20372990