Phosphorylation of polynucleotide kinase/ phosphatase by DNA-dependent protein kinase and ataxia-telangiectasia mutated regulates its association with sites of DNA damage. (Q39888783)

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English	Phosphorylation of polynucleotide kinase/ phosphatase by DNA-dependent protein kinase and ataxia-telangiectasia mutated regulates its association with sites of DNA damage.	scientific article

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9 February 2020

Phosphorylation of polynucleotide kinase/ phosphatase by DNA-dependent protein kinase and ataxia-telangiectasia mutated regulates its association with sites of DNA damage (English)

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9 February 2020

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phosphorylation

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Michael J. Hendzel

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9 February 2020

author name string

Angela E Zolner

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9 February 2020

Ismail Abdou

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Ruiqiong Ye

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9 February 2020

Rajam S Mani

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9 February 2020

Mesfin Fanta

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Yaping Yu

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Pauline Douglas

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Nasser Tahbaz

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9 February 2020

Shujuan Fang

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Tracey Dobbs

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Chen Wang

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Nick Morrice

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Michael Weinfeld

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9 February 2020

Susan P Lees-Miller

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9 February 2020

publication date

8 August 2011

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9 February 2020

Nucleic Acids Research

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9 February 2020

39

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9 February 2020

9224-9237

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9 February 2020

21

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9 February 2020

copyright license

Creative Commons Attribution-NonCommercial 3.0 Unported

4 October 2016

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3241656/fullTextXML

based on heuristic

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ATM-mediated phosphorylation of polynucleotide kinase/phosphatase is required for effective DNA double-strand break repair

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241656

22 September 2017

Tidying up loose ends: the role of polynucleotide kinase/phosphatase in DNA strand break repair

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241656

22 September 2017

Substrate channeling in mammalian base excision repair pathways: passing the baton

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241656

22 September 2017

Dual modes of interaction between XRCC4 and polynucleotide kinase/phosphatase: implications for nonhomologous end joining

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241656

22 September 2017

DNA end-processing enzyme polynucleotide kinase as a potential target in the treatment of cancer

1 reference

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22 September 2017

Site-specific phosphorylation dynamics of the nuclear proteome during the DNA damage response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241656

22 September 2017

Mutations in PNKP cause microcephaly, seizures and defects in DNA repair

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241656

22 September 2017

Mechanism of DNA substrate recognition by the mammalian DNA repair enzyme, Polynucleotide Kinase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241656

22 September 2017

Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241656

22 September 2017

Polynucleotide kinase as a potential target for enhancing cytotoxicity by ionizing radiation and topoisomerase I inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241656

22 September 2017

Profiling of UV-induced ATM/ATR signaling pathways.

1 reference

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22 September 2017

APLF (C2orf13) facilitates nonhomologous end-joining and undergoes ATM-dependent hyperphosphorylation following ionizing radiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241656

22 September 2017

Human polynucleotide kinase participates in repair of DNA double-strand breaks by nonhomologous end joining but not homologous recombination

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241656

22 September 2017

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241656

22 September 2017

The DNA-dependent protein kinase catalytic subunit is phosphorylated in vivo on threonine 3950, a highly conserved amino acid in the protein kinase domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241656

22 September 2017

Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441.

1 reference

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22 September 2017

The molecular architecture of the mammalian DNA repair enzyme, polynucleotide kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241656

22 September 2017

Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241656

22 September 2017

Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IV

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241656

22 September 2017

Biochemical characterization of the ataxia-telangiectasia mutated (ATM) protein from human cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241656

22 September 2017

Stable down-regulation of human polynucleotide kinase enhances spontaneous mutation frequency and sensitizes cells to genotoxic agents

1 reference

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22 September 2017

Identification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase

1 reference

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22 September 2017

Involvement of human polynucleotide kinase in double-strand break repair by non-homologous end joining

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241656

22 September 2017

The plant isoflavenoid genistein activates p53 and Chk2 in an ATM-dependent manner

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241656

22 September 2017

Molecular characterization of a human DNA kinase

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241656

22 September 2017

Molecular cloning of the human gene, PNKP, encoding a polynucleotide kinase 3'-phosphatase and evidence for its role in repair of DNA strand breaks caused by oxidative damage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241656

22 September 2017

Requirement for the kinase activity of human DNA-dependent protein kinase catalytic subunit in DNA strand break rejoining

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241656

22 September 2017

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241656

22 September 2017

Lack of correlation between ATM protein expression and tumour cell radiosensitivity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241656

22 September 2017

Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241656

22 September 2017

gamma Ray induced deoxyribonucleic acid strand breaks. 3' Glycolate termini

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241656

22 September 2017

Absence of p350 subunit of DNA-activated protein kinase from a radiosensitive human cell line

1 reference

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25 September 2017

DNA-PK and ATM phosphorylation sites in XLF/Cernunnos are not required for repair of DNA double strand breaks

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3241656

15 June 2018

Oxygen--effect on strand breaks and specific end-groups in DNA of irradiated thymocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/21824916

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of nitrogen, oxygen, and nitroimidazole radiosensitizers on DNA damage induced by ionizing radiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21824916

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purification and characterization of the double-stranded DNA-activated protein kinase, DNA-PK, from human placenta

1 reference

https://pubmed.ncbi.nlm.nih.gov/21824916

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purification and substrate specificity of polydeoxyribonucleotide kinases isolated from calf thymus and rat liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/21824916

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1093/NAR/GKR647

1 reference

Europe PubMed Central

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9 February 2020

1 reference

Europe PubMed Central

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9 February 2020

1 reference

Europe PubMed Central

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9 February 2020

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