A selective inhibitor Gal-PUGNAc of human lysosomal beta-hexosaminidases modulates levels of the ganglioside GM2 in neuroblastoma cells. (Q39897669)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19130519%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

title

A selective inhibitor Gal-PUGNAc of human lysosomal beta-hexosaminidases modulates levels of the ganglioside GM2 in neuroblastoma cells (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19130519%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

1 reference

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19130519%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Keith A. Stubbs

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19130519%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

David J Vocadlo

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19130519%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

author name string

Keith A Stubbs

1

1 reference

15 September 2017

David J Vocadlo

3

1 reference

15 September 2017

language of work or name

English

0 references

publication date

1 January 2009

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19130519%20AND%20SRC:MED&resulttype=core&format=json

Angewandte Chemie International Edition

19 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19130519%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

volume

48

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19130519%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

issue

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19130519%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

page(s)

1300-1303

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19130519%20AND%20SRC:MED&resulttype=core&format=json

The beta-hexosaminidase story in Toronto: from enzyme structure to gene mutation.

19 January 2020

cites work

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200804583

Naturally occurring mutations in GM2 gangliosidosis: a compendium

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200804583

Lysosomal glycosphingolipid recognition by NKT cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200804583

Functional role of glycosphingolipids and gangliosides in control of cell adhesion, motility, and growth, through glycosynaptic microdomains

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200804583

Overexpression of Plasma Membrane-associated Sialidase Attenuates Insulin Signaling in Transgenic Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200804583

Cycling of O-linked beta-N-acetylglucosamine on nucleocytoplasmic proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200804583

NAG-thiazoline, An N -Acetyl-β-hexosaminidase Inhibitor That Implicates Acetamido Participation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200804583

Bacterial chitobiase structure provides insight into catalytic mechanism and the basis of Tay-Sachs disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200804583

O-GlcNAcase uses substrate-assisted catalysis: kinetic analysis and development of highly selective mechanism-inspired inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200804583

A divergent synthesis of 2-acyl derivatives of PUGNAc yields selective inhibitors of O-GlcNAcase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200804583

GlcNAcstatin: a picomolar, selective O-GlcNAcase inhibitor that modulates intracellular O-glcNAcylation levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200804583

A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200804583

Elevation of Global O-GlcNAc Levels in 3T3-L1 Adipocytes by Selective Inhibition of O-GlcNAcase Does Not Induce Insulin Resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200804583

N-acetylglucosaminono-1,5-lactone oxime and the corresponding (phenylcarbamoyl)oxime. Novel and potent inhibitors of beta-N-acetylglucosaminidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200804583

N-Acetylhexosaminidase inhibitory properties of C-1 homologated GlcNAc- and GalNAc-thiazolines

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200804583

Structural and mechanistic insight into the basis of mucopolysaccharidosis IIIB

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200804583

High-throughput screening for human lysosomal beta-N-Acetyl hexosaminidase inhibitors acting as pharmacological chaperones

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200804583