Near complete rescue of experimental Parkinson's disease with intravenous, non-viral GDNF gene therapy (Q39902228)

15 September 2017

Near complete rescue of experimental Parkinson's disease with intravenous, non-viral GDNF gene therapy (English)

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15 September 2017

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15 September 2017

Yun Zhang

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15 September 2017

23 December 2008

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15 September 2017

Pharmaceutical Research

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15 September 2017

26

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5

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15 September 2017

1059-1063

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Repetitive vibrissae-elicited forelimb placing before and immediately after unilateral 6-hydroxydopamine improves outcome in a model of Parkinson's disease.

15 September 2017

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12 December 2020

Iron-independent neuronal expression of transferrin receptor mRNA in the rat

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12 December 2020

Absence of toxicity of chronic weekly intravenous gene therapy with pegylated immunoliposomes

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12 December 2020

Organ-specific expression of the lacZ gene controlled by the opsin promoter after intravenous gene administration in adult mice

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12 December 2020

Comparison of cDNA and genomic forms of tyrosine hydroxylase gene therapy of the brain with Trojan horse liposomes

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12 December 2020

Glial cell line-derived neurotrophic factor does not enter normal mouse brain

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12 December 2020

Intravenous glial-derived neurotrophic factor gene therapy of experimental Parkinson's disease with Trojan horse liposomes and a tyrosine hydroxylase promoter

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12 December 2020

Gene targeting in vivo with pegylated immunoliposomes

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12 December 2020

The human tyrosine hydroxylase gene promoter

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12 December 2020

5' upstream DNA sequence of the rat tyrosine hydroxylase gene directs high-level and tissue-specific expression to catecholaminergic neurons in the central nervous system of transgenic mice.

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12 December 2020

Intravenous nonviral gene therapy causes normalization of striatal tyrosine hydroxylase and reversal of motor impairment in experimental parkinsonism.

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12 December 2020

Tissue-specific and high-level expression of the human tyrosine hydroxylase gene in transgenic mice.

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12 December 2020

Glial cell line-derived neurotrophic factor attenuates behavioural deficits and regulates nigrostriatal dopaminergic and peptidergic markers in 6-hydroxydopamine-lesioned adult rats: comparison of intraventricular and intranigral delivery

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12 December 2020

Brain-specific expression of an exogenous gene after i.v. administration

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12 December 2020

Global non-viral gene transfer to the primate brain following intravenous administration.

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12 December 2020

Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease

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12 December 2020

Organ-specific gene expression in the rhesus monkey eye following intravenous non-viral gene transfer

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12 December 2020

Noninvasive gene targeting to the brain

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12 December 2020

Transport of [125I]transferrin through the rat blood-brain barrier

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12 December 2020

GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons

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12 December 2020

Glial cell line-derived neurotrophic factor reverses toxin-induced injury to midbrain dopaminergic neurons in vivo

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12 December 2020

Intraputamenal infusion of glial cell line-derived neurotrophic factor in PD: a two-year outcome study.

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12 December 2020

Aberrant sprouting and downregulation of tyrosine hydroxylase in lesioned nigrostriatal dopamine neurons induced by long-lasting overexpression of glial cell line derived neurotrophic factor in the striatum by lentiviral gene transfer

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12 December 2020

Examination of blood-brain barrier transferrin receptor by confocal fluorescent microscopy of unfixed isolated rat brain capillaries

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12 December 2020

Does neuronal expression of GDNF effectively protect dopaminergic neurons in a rat model of Parkinson's disease?

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12 December 2020

Continuous low-level glial cell line-derived neurotrophic factor delivery using recombinant adeno-associated viral vectors provides neuroprotection and induces behavioral recovery in a primate model of Parkinson's disease.

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12 December 2020

Functional reinnervation from remaining DA terminals induced by GDNF lentivirus in a rat model of early Parkinson's disease.

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12 December 2020

Cloning and cell type-specific regulation of the human tyrosine hydroxylase gene promoter

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12 December 2020

10.1007/S11095-008-9815-9

Identifiers

DOI

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15 September 2017

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PubMed ID

19104914