Target of γ-secretase modulators, presenilin marks the spot (Q39921478)

15 September 2017

Target of γ-secretase modulators, presenilin marks the spot (English)

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15 September 2017

Christina J Crump

1

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15 September 2017

Douglas S Johnson

series ordinal

2

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15 September 2017

Yue-Ming Li

series ordinal

3

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15 September 2017

language of work or name

English

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publication date

30 November 2011

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15 September 2017

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15 September 2017

30

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15 September 2017

23

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15 September 2017

4696-4698

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Piperidine acetic acid based γ-secretase modulators directly bind to Presenilin-1.

15 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242977

Phenylpiperidine-type γ-secretase modulators target the transmembrane domain 1 of presenilin 1

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242977

Novel γ-secretase enzyme modulators directly target presenilin protein

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242977

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242977

Substrate docking to γ-secretase allows access of γ-secretase modulators to an allosteric site

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242977

Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242977

Substrate-targeting gamma-secretase modulators

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242977

Selected non-steroidal anti-inflammatory drugs and their derivatives target gamma-secretase at a novel site. Evidence for an allosteric mechanism.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242977

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242977

NSAID-based γ-secretase modulators do not bind to the amyloid-β polypeptide

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242977

A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3242977

20 August 2018

Identifiers

DOI

10.1038/EMBOJ.2011.410

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15 September 2017

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15 September 2017

PubMed publication ID

22126818

1 reference