Nuclear protein tyrosine phosphatase Shp-2 is one important negative regulator of nuclear export of telomerase reverse transcriptase. (Q39933637)

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15 January 2020

title

Nuclear protein tyrosine phosphatase Shp-2 is one important negative regulator of nuclear export of telomerase reverse transcriptase (English)

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15 January 2020

5

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15 January 2020

Judith Haendeler

7

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15 January 2020

author name string

Sascha Jakob

1

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15 January 2020

Peter Schroeder

2

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15 January 2020

Margarete Lukosz

3

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15 January 2020

Nicole Büchner

4

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15 January 2020

Joachim Altschmied

6

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15 January 2020

language of work or name

English

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publication date

1 October 2008

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Journal of Biological Chemistry

15 January 2020

published in

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15 January 2020

volume

283

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15 January 2020

issue

48

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15 January 2020

page(s)

33155-33161

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Novel roles for telomerase in aging

15 January 2020

cites work

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ERK1/2 associates with the c-Met-binding domain of growth factor receptor-bound protein 2 (Grb2)-associated binder-1 (Gab1): role in ERK1/2 and early growth response factor-1 (Egr-1) nuclear accumulation

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Hydrogen peroxide triggers nuclear export of telomerase reverse transcriptase via Src kinase family-dependent phosphorylation of tyrosine 707.

22 September 2017

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22 September 2017

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Role of the SHP-2 tyrosine phosphatase in cytokine-induced signaling and cellular response

22 September 2017

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Prolactin induces SHP-2 association with Stat5, nuclear translocation, and binding to the beta-casein gene promoter in mammary cells

22 September 2017

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Telomerase reverse transcriptase promotes cardiac muscle cell proliferation, hypertrophy, and survival

22 September 2017

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Telomere dysfunction triggers developmentally regulated germ cell apoptosis.

22 September 2017

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Emerging roles for telomerase in neuronal development and apoptosis

22 September 2017

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Modulation of protein kinase activity and gene expression by reactive oxygen species and their role in vascular physiology and pathophysiology

22 September 2017

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Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation

22 September 2017

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The catalytic subunit of telomerase protects neurons against amyloid beta-peptide-induced apoptosis

22 September 2017

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Studies of the molecular mechanisms in the regulation of telomerase activity

22 September 2017

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Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization

22 September 2017

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Telomerase is controlled by protein kinase Calpha in human breast cancer cells

22 September 2017

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Extension of life-span by introduction of telomerase into normal human cells

22 September 2017

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hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization

22 September 2017

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Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase Shp-2.

22 September 2017

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Multiple requirements for SHPTP2 in epidermal growth factor-mediated cell cycle progression

22 September 2017

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Protein-tyrosine-phosphatase SHPTP2 is a required positive effector for insulin downstream signaling.

22 September 2017

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The third cytoplasmic loop of the angiotensin II type 1 receptor exerts differential effects on extracellular signal-regulated kinase (ERK1/ERK2) and apoptosis via Ras- and Rap1-dependent pathways

22 September 2017

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Human endothelial cell life extension by telomerase expression

25 September 2017

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Expression of catalytically inactive Syp phosphatase in 3T3 cells blocks stimulation of mitogen-activated protein kinase by insulin.

15 June 2018

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Antioxidants inhibit nuclear export of telomerase reverse transcriptase and delay replicative senescence of endothelial cells.

15 June 2018

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The novel role of the C-terminal region of SHP-2. Involvement of Gab1 and SHP-2 phosphatase activity in Elk-1 activation

20 August 2018

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20 August 2018

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20 August 2018

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Ending up with the right partner

20 August 2018

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Crossref

https://api.crossref.org/works/10.1074%2FJBC.M805138200

Telomerase does not counteract telomere shortening but protects mitochondrial function under oxidative stress

21 January 2018

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12 December 2020

Shear stress inhibits apoptosis of human endothelial cells

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12 December 2020

Inhibition of experimental liver cirrhosis in mice by telomerase gene delivery

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12 December 2020

Regulation of the hTERT telomerase catalytic subunit by the c-Abl tyrosine kinase

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12 December 2020

Nitric oxide activates telomerase and delays endothelial cell senescence

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12 December 2020

Akt protein kinase enhances human telomerase activity through phosphorylation of telomerase reverse transcriptase subunit

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12 December 2020

Mitochondrial localization of telomerase as a determinant for hydrogen peroxide-induced mitochondrial DNA damage and apoptosis

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12 December 2020

Identifiers

DOI

10.1074/JBC.M805138200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18829466%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

1 reference

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15 January 2020

1 reference