Metformin for chemoprevention of metachronous colorectal adenoma or polyps in post-polypectomy patients without diabetes: a multicentre double-blind, placebo-controlled, randomised phase 3 trial. (Q39944738)

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English	Metformin for chemoprevention of metachronous colorectal adenoma or polyps in post-polypectomy patients without diabetes: a multicentre double-blind, placebo-controlled, randomised phase 3 trial.	scientific article

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scholarly article

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10 March 2020

Metformin for chemoprevention of metachronous colorectal adenoma or polyps in post-polypectomy patients without diabetes: a multicentre double-blind, placebo-controlled, randomised phase 3 trial (English)

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10 March 2020

phase III clinical trial

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multicenter clinical trial

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inferred from title

colorectal adenoma

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Takaomi Kessoku

13

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10 March 2020

Atsushi Nakajima

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Atsushi Nakajima

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10 March 2020

Takashi Uchiyama

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Takashi Uchiyama

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10 March 2020

Hirokazu Takahashi

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Hirokazu Takahashi

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10 March 2020

Kunihiro Hosono

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Kunihiro Hosono

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10 March 2020

Takuma Higurashi

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Takuma Higurashi

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10 March 2020

8

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Leo Taniguchi

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10 March 2020

9

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Yasuo Hata

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10 March 2020

12

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Hajime Nagase

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10 March 2020

17

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Shoji Yamanaka

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10 March 2020

Yoshiaki Inayama

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Yoshiaki Inayama

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10 March 2020

Nobuyuki Matsuhashi

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object named as

Nobuyuki Matsuhashi

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10 March 2020

Yasuhiko Komiya

4

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Yasuhiko Komiya

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10 March 2020

Masataka Taguri

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Masataka Taguri

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10 March 2020

Shotaro Umezawa

5

object named as

Shotaro Umezawa

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10 March 2020

14

object named as

Jun Arimoto

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10 March 2020

author name string

Eiji Sakai

6

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10 March 2020

Shiori Uchiyama

10

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10 March 2020

Akiko Hattori

11

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10 March 2020

publication date

3 March 2016

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10 March 2020

Lancet Oncology Commission

1 reference

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10 March 2020

17

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10 March 2020

475-483

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10 March 2020

4

1 reference

Europe PubMed Central

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10 March 2020

Global cancer statistics, 2012

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2815%2900565-3

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Prevention of colorectal cancer by colonoscopic polypectomy. The National Polyp Study Workgroup

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2815%2900565-3

7 January 2021

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Five-year risk of colorectal neoplasia after negative screening colonoscopy

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2815%2900565-3

7 January 2021

based on heuristic

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Chemoprevention of colorectal cancer

1 reference

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7 January 2021

based on heuristic

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COX-2 inhibitors--a lesson in unexpected problems

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7 January 2021

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Risk of cardiovascular events in a randomized placebo-controlled, double-blind trial of difluoromethylornithine plus sulindac for the prevention of sporadic colorectal adenomas

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2815%2900565-3

7 January 2021

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Clinically confirmed type 2 diabetes mellitus and colorectal cancer risk: a population-based, retrospective cohort study.

1 reference

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7 January 2021

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Influence of obesity on the risk of developing colon cancer

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Glibenclamide, metformin, and insulin for the treatment of gestational diabetes: a systematic review and meta-analysis

1 reference

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Metformin activates a duodenal Ampk-dependent pathway to lower hepatic glucose production in rats.

1 reference

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The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin

1 reference

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7 January 2021

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Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activation

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

New users of metformin are at low risk of incident cancer: a cohort study among people with type 2 diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2815%2900565-3

7 January 2021

based on heuristic

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Metformin suppresses intestinal polyp growth in ApcMin/+ mice

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2815%2900565-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Metformin suppresses azoxymethane-induced colorectal aberrant crypt foci by activating AMP-activated protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2815%2900565-3

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Metformin suppresses colorectal aberrant crypt foci in a short-term clinical trial

1 reference

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7 January 2021

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Aberrant crypt foci of the colon as precursors of adenoma and cancer

1 reference

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Metformin efficacy and safety for colorectal polyps: a double-blind randomized controlled trial

1 reference

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Use and abuse of HOMA modeling

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7 January 2021

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Randomized double-blind trial of sulindac and etodolac to eradicate aberrant crypt foci and to prevent sporadic colorectal polyps

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2815%2900565-3

7 January 2021

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Metabolic factors accelerate colorectal adenoma recurrence

1 reference

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7 January 2021

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The preventive effects of low-dose enteric-coated aspirin tablets on the development of colorectal tumours in Asian patients: a randomised trial.

1 reference

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Targeting metabolism for cancer treatment and prevention: metformin, an old drug with multi-faceted effects

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2815%2900565-3

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inferred from DOI database lookup

Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2815%2900565-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Metformin blocks the stimulative effect of a high-energy diet on colon carcinoma growth in vivo and is associated with reduced expression of fatty acid synthase

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

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1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2815%2900565-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Metformin does not affect cancer risk: a cohort study in the U.K. Clinical Practice Research Datalink analyzed like an intention-to-treat trial.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2815%2900565-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Cancer outcomes and all-cause mortality in adults allocated to metformin: systematic review and collaborative meta-analysis of randomised clinical trials.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2815%2900565-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Metformin for primary colorectal cancer prevention in patients with diabetes: a case-control study in a US population

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2815%2900565-3

7 January 2021

based on heuristic

inferred from DOI database lookup

High and typical 18F-FDG bowel uptake in patients treated with metformin

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2815%2900565-3

7 January 2021

based on heuristic

inferred from DOI database lookup

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1 reference

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based on heuristic

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Identifiers

10.1016/S1470-2045(15)00565-3

1 reference

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10 March 2020

1 reference

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10 March 2020

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