IKKalpha is a p63 transcriptional target involved in the pathogenesis of ectodermal dysplasias (Q39960410)

15 September 2017

title

IKKalpha is a p63 transcriptional target involved in the pathogenesis of ectodermal dysplasias (English)

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9

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12

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Michael Karin

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11

Dennis R Roop

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3

Maranke I Koster

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Barbara Marinari

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15 September 2017

Costanza Ballaro

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Maria Laura Giustizieri

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Francesca Moretti

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Francesca Crosti

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Marina Papoutsaki

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Sergio Chimenti

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language of work or name

English

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publication date

17 July 2008

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Journal of Investigative Dermatology

15 September 2017

published in

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volume

129

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issue

1

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page(s)

60-69

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P63 gene mutations and human developmental syndromes.

15 September 2017

cites work

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https://api.crossref.org/works/10.1038%2FJID.2008.202

7 January 2021

p63 is upstream of IKK alpha in epidermal development

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https://api.crossref.org/works/10.1038%2FJID.2008.202

7 January 2021

DNA damage-dependent acetylation of p73 dictates the selective activation of apoptotic target genes.

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https://api.crossref.org/works/10.1038%2FJID.2008.202

7 January 2021

IKKalpha is a critical coregulator of a Smad4-independent TGFbeta-Smad2/3 signaling pathway that controls keratinocyte differentiation

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https://api.crossref.org/works/10.1038%2FJID.2008.202

7 January 2021

Identification and characterization of the IKKalpha promoter: positive and negative regulation by ETS-1 and p53, respectively

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https://api.crossref.org/works/10.1038%2FJID.2008.202

7 January 2021

Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase

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https://api.crossref.org/works/10.1038%2FJID.2008.202

7 January 2021

p63 induces key target genes required for epidermal morphogenesis

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https://api.crossref.org/works/10.1038%2FJID.2008.202

7 January 2021

p63 is the molecular switch for initiation of an epithelial stratification program

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https://api.crossref.org/works/10.1038%2FJID.2008.202

7 January 2021

The role of p63 in development and differentiation of the epidermis

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https://api.crossref.org/works/10.1038%2FJID.2008.202

7 January 2021

p63 regulates multiple signalling pathways required for ectodermal organogenesis and differentiation

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https://api.crossref.org/works/10.1038%2FJID.2008.202

7 January 2021

IKK1-deficient mice exhibit abnormal development of skin and skeleton

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https://api.crossref.org/works/10.1038%2FJID.2008.202

7 January 2021

Hay-Wells syndrome is caused by heterozygous missense mutations in the SAM domain of p63

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https://api.crossref.org/works/10.1038%2FJID.2008.202

7 January 2021

p63 is a p53 homologue required for limb and epidermal morphogenesis

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https://api.crossref.org/works/10.1038%2FJID.2008.202

7 January 2021

Restoration of wild-type conformation and activity of a temperature-sensitive mutant of p53 (p53(V272M)) by the cytoprotective aminothiol WR1065 in the esophageal cancer cell line TE-1.

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https://api.crossref.org/works/10.1038%2FJID.2008.202

7 January 2021

p63-specific activation of the BPAG-1e promoter

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https://api.crossref.org/works/10.1038%2FJID.2008.202

7 January 2021

Differential recognition of response elements determines target gene specificity for p53 and p63

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https://api.crossref.org/works/10.1038%2FJID.2008.202

7 January 2021

Pattern of p63 mutations and their phenotypes--update

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https://api.crossref.org/works/10.1038%2FJID.2008.202

7 January 2021

IkappaB kinase-alpha acts in the epidermis to control skeletal and craniofacial morphogenesis

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https://api.crossref.org/works/10.1038%2FJID.2008.202

7 January 2021

p63 protects the female germ line during meiotic arrest

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https://api.crossref.org/works/10.1038%2FJID.2008.202

7 January 2021

Limb and skin abnormalities in mice lacking IKKalpha

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https://api.crossref.org/works/10.1038%2FJID.2008.202

7 January 2021

p63 regulates proliferation and differentiation of developmentally mature keratinocytes

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https://api.crossref.org/works/10.1038%2FJID.2008.202

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https://api.crossref.org/works/10.1038%2FJID.2008.202

1 reference

7 January 2021

p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities

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https://api.crossref.org/works/10.1038%2FJID.2008.202

7 January 2021

p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development

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https://api.crossref.org/works/10.1038%2FJID.2008.202

7 January 2021

Identifiers

DOI

10.1038/JID.2008.202

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15 September 2017

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