Resistance to FLT3 inhibition in an in vitro model of primary AML cells with a stem cell phenotype in a defined microenvironment. (Q39977455)

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8 January 2020

title

Resistance to FLT3 inhibition in an in vitro model of primary AML cells with a stem cell phenotype in a defined microenvironment (English)

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8 January 2020

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3

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8 January 2020

author name string

U Mony

1

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8 January 2020

M Jawad

2

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8 January 2020

N Russell

4

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8 January 2020

M Pallis

5

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8 January 2020

publication date

29 May 2008

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8 January 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18509353%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

volume

22

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8 January 2020

issue

7

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8 January 2020

page(s)

1395-1401

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https://scigraph.springernature.com/pub.10.1038/leu.2008.125

8 January 2020

exact match

0 references

cites work

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High stem cell frequency in acute myeloid leukemia at diagnosis predicts high minimal residual disease and poor survival

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The interleukin-3 receptor alpha chain is a unique marker for human acute myelogenous leukemia stem cells

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Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche

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Single-agent CEP-701, a novel FLT3 inhibitor, shows biologic and clinical activity in patients with relapsed or refractory acute myeloid leukemia

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Patients with acute myeloid leukemia and an activating mutation in FLT3 respond to a small-molecule FLT3 tyrosine kinase inhibitor, PKC412.

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Internal tandem duplications of the FLT3 gene are present in leukemia stem cells

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Inhibition of the transforming activity of FLT3 internal tandem duplication mutants from AML patients by a tyrosine kinase inhibitor

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The expression of P-glycoprotein in AML cells with FLT3 internal tandem duplications is associated with reduced apoptosis in response to FLT3 inhibitors

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DNA repair contributes to the drug-resistant phenotype of primary acute myeloid leukaemia cells with FLT3 internal tandem duplications and is reversed by the FLT3 inhibitor PKC412.

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Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region.

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Nuclear factor-kappaB is constitutively activated in primitive human acute myelogenous leukemia cells

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The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the Unite

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Proliferative status of primitive hematopoietic progenitors from patients with acute myelogenous leukemia (AML)

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7 January 2021

Detection and clinical significance of human acute myeloid leukaemia progenitors capable of long-term proliferation in vitro

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7 January 2021

Microvascular endothelial cells increase proliferation and inhibit apoptosis of native human acute myelogenous leukemia blasts

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7 January 2021

Regulation of constitutive STAT5 phosphorylation in acute myeloid leukemia blasts.

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7 January 2021

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Aberrant marker expression patterns on the CD34+CD38- stem cell compartment in acute myeloid leukemia allows to distinguish the malignant from the normal stem cell compartment both at diagnosis and in remission

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7 January 2021