The PIM1 kinase is a critical component of a survival pathway activated by docetaxel and promotes survival of docetaxel-treated prostate cancer cells. (Q39989937)

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English	The PIM1 kinase is a critical component of a survival pathway activated by docetaxel and promotes survival of docetaxel-treated prostate cancer cells.	scientific article

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6 January 2020

The PIM1 kinase is a critical component of a survival pathway activated by docetaxel and promotes survival of docetaxel-treated prostate cancer cells (English)

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6 January 2020

prostate cancer

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based on heuristic

inferred from title

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based on heuristic

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2

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author name string

Marina Zemskova

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6 January 2020

Svetlana Bashkirova

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Michael Lilly

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21 April 2008

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Journal of Biological Chemistry

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283

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20635-20644

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6 January 2020

Apoptotic cell death induced by low-dose radiation in male germ cells: hormesis and adaptation

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Structural analysis identifies imidazo[1,2-b]pyridazines as PIM kinase inhibitors with in vitro antileukemic activity

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Molecular profiling of docetaxel cytotoxicity in breast cancer cells: uncoupling of aberrant mitosis and apoptosis.

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Small interfering RNA targeting epidermal growth factor receptor enhances chemosensitivity to cisplatin, 5-fluorouracil and docetaxel in head and neck squamous cell carcinoma

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The hypoxic inducible stress response as a target for cancer drug discovery

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Aspirin reduces the outcome of anticancer therapy in Meth A-bearing mice through activation of AKT-glycogen synthase kinase signaling

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22 September 2017

Novel role of Stat1 in the development of docetaxel resistance in prostate tumor cells

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Clinical pharmacokinetics of docetaxel : recent developments

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Cancer biology and hormesis: human tumor cell lines commonly display hormetic (biphasic) dose responses

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Epidermal growth factor receptor inhibitor (PD168393) potentiates cytotoxic effects of paclitaxel against androgen-independent prostate cancer cells

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Structural basis of inhibitor specificity of the human protooncogene proviral insertion site in moloney murine leukemia virus (PIM-1) kinase

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Docetaxel induces cell death through mitotic catastrophe in human breast cancer cells

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Pim-1 kinase stability is regulated by heat shock proteins and the ubiquitin-proteasome pathway

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Complementary functions of the antiapoptotic protein A1 and serine/threonine kinase pim-1 in the BCR/ABL-mediated leukemogenesis

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Interleukin 6, a nuclear factor-kappaB target, predicts resistance to docetaxel in hormone-independent prostate cancer and nuclear factor-kappaB inhibition by PS-1145 enhances docetaxel antitumor activity.

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Pim-1 kinase inhibits the activation of reporter gene expression in Elk-1 and c-Fos reporting systems but not the endogenous gene expression: an artifact of the reporter gene assay by transient co-transfection

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Overexpression of PIM-1 is a potential biomarker in prostate carcinoma

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IL-5 and granulocyte-macrophage colony-stimulating factor activate STAT3 and STAT5 and promote Pim-1 and cyclin D3 protein expression in human eosinophils

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20 August 2018

Pim-1 kinase promotes inactivation of the pro-apoptotic Bad protein by phosphorylating it on the Ser112 gatekeeper site

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20 August 2018

Pim-1 expression in prostatic intraepithelial neoplasia and human prostate cancer

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[Pim-1 induced by hypoxia is involved in drug resistance and tumorigenesis of solid tumor cells].

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Antioxidants relieve phosphatase inhibition and reduce PDGF signaling in cultured VSMCs and in restenosis

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12 December 2020

based on heuristic

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Clinical and pathologic significance of activation of signal transducer and activator of transcription 3 in prostate cancer

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12 December 2020

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The role of oxidative stress in hormesis induced by sodium arsenite in human embryo lung fibroblast (HELF) cellular proliferation model

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12 December 2020

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Heat shock protein expression in human tumours grown in severe combined immunodeficient mice

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12 December 2020

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Efficacy of cytotoxic agents against human tumor xenografts is markedly enhanced by coadministration of ZD1839 (Iressa), an inhibitor of EGFR tyrosine kinase

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12 December 2020

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Adenovirus-mediated inhibition of NF-kappaB confers chemo-sensitization and apoptosis in prostate cancer cells

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12 December 2020

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Quantification of cells cultured on 96-well plates

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12 December 2020

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Pulse treatment of interphasic HeLa cells with nanomolar doses of docetaxel affects centrosome organization and leads to catastrophic exit of mitosis

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Interferon-alpha activates multiple STAT proteins and upregulates proliferation-associated IL-2Ralpha, c-myc, and pim-1 genes in human T cells

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Identifiers

10.1074/JBC.M709479200

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Europe PubMed Central

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6 January 2020

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6 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18426800%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

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