Transactivation of a viral target gene by herpes simplex virus ICP27 is posttranscriptional and does not require the endogenous promoter or polyadenylation site (Q39996395)

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English	Transactivation of a viral target gene by herpes simplex virus ICP27 is posttranscriptional and does not require the endogenous promoter or polyadenylation site	scientific article

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scholarly article

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Europe PubMed Central

PMC publication ID

16 September 2017

Transactivation of a viral target gene by herpes simplex virus ICP27 is posttranscriptional and does not require the endogenous promoter or polyadenylation site (English)

1 reference

Europe PubMed Central

PMC publication ID

16 September 2017

author name string

Keith D Perkins

1

1 reference

Europe PubMed Central

PMC publication ID

16 September 2017

Jennifer Gregonis

2

1 reference

Europe PubMed Central

PMC publication ID

16 September 2017

Sarah Borge

3

1 reference

Europe PubMed Central

PMC publication ID

16 September 2017

Stephen A Rice

4

1 reference

Europe PubMed Central

PMC publication ID

16 September 2017

language of work or name

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publication date

1 September 2003

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Europe PubMed Central

PMC publication ID

16 September 2017

Journal of Virology

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Europe PubMed Central

PMC publication ID

16 September 2017

77

1 reference

Europe PubMed Central

PMC publication ID

16 September 2017

18

1 reference

Europe PubMed Central

PMC publication ID

16 September 2017

9872-9884

1 reference

Europe PubMed Central

PMC publication ID

16 September 2017

ICP27 interacts with the RNA export factor Aly/REF to direct herpes simplex virus type 1 intronless mRNAs to the TAP export pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=224566

22 September 2017

Association of herpes simplex virus type 1 ICP8 and ICP27 proteins with cellular RNA polymerase II holoenzyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=224566

22 September 2017

A conserved mRNA export machinery coupled to pre-mRNA splicing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=224566

22 September 2017

The initiator element in a herpes simplex virus type 1 late-gene promoter enhances activation by ICP4, resulting in abundant late-gene expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=224566

22 September 2017

Herpes simplex virus ICP27 protein provides viral mRNAs with access to the cellular mRNA export pathway.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=224566

22 September 2017

RNA polymerase II holoenzyme modifications accompany transcription reprogramming in herpes simplex virus type 1-infected cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=224566

22 September 2017

Regulation of herpes simplex virus gene expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=224566

22 September 2017

Herpes simplex virus type 1 ICP4 promotes transcription preinitiation complex formation by enhancing the binding of TFIID to DNA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=224566

22 September 2017

ICP0, a regulator of herpes simplex virus during lytic and latent infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=224566

22 September 2017

Functionally significant secondary structure of the simian virus 40 late polyadenylation signal

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=224566

22 September 2017

Herpes simplex virus ICP27 induces cytoplasmic accumulation of unspliced polyadenylated alpha-globin pre-mRNA in infected HeLa cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=224566

22 September 2017

Herpesvirus mRNAs are sorted for export via Crm1-dependent and -independent pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=224566

22 September 2017

The herpes simplex virus type 1 regulatory protein ICP27 is required for the prevention of apoptosis in infected human cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=224566

22 September 2017

ICP27 mediates HSV RNA export by shuttling through a leucine-rich nuclear export signal and binding viral intronless RNAs through an RGG motif

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=224566

22 September 2017

Shuttling of the herpes simplex virus type 1 regulatory protein ICP27 between the nucleus and cytoplasm mediates the expression of late proteins.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=224566

22 September 2017

Activation of gene expression by herpes simplex virus type 1 ICP0 occurs at the level of mRNA synthesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=224566

22 September 2017

Repression of host RNA polymerase II transcription by herpes simplex virus type 1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=224566

22 September 2017

Herpes simplex virus immediate-early proteins ICP0 and ICP4 activate the endogenous human alpha-globin gene in nonerythroid cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=224566

22 September 2017

Physical and functional interactions between herpes simplex virus immediate-early proteins ICP4 and ICP27.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=224566

22 September 2017

The RGG box motif of the herpes simplex virus ICP27 protein mediates an RNA-binding activity and determines in vivo methylation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=224566

22 September 2017

Overexpression of the herpes simplex virus type 1 immediate-early regulatory protein, ICP27, is responsible for the aberrant localization of ICP0 and mutant forms of ICP4 in ICP4 mutant virus-infected cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=224566

22 September 2017

Herpes simplex ICP27 mutant viruses exhibit reduced expression of specific DNA replication genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=224566

22 September 2017

Regulation of herpes simplex virus poly (A) site usage and the action of immediate-early protein IE63 in the early-late switch.

1 reference

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22 September 2017

The acidic amino-terminal region of herpes simplex virus type 1 alpha protein ICP27 is required for an essential lytic function.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=224566

22 September 2017

Amino acid substitution mutations in the herpes simplex virus ICP27 protein define an essential gene regulation function.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=224566

22 September 2017

The herpes simplex virus regulatory protein ICP27 contributes to the decrease in cellular mRNA levels during infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=224566

22 September 2017

Herpes simplex virus inhibits host cell splicing, and regulatory protein ICP27 is required for this effect

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=224566

22 September 2017

Functional interactions between herpes simplex virus immediate-early proteins during infection: gene expression as a consequence of ICP27 and different domains of ICP4

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=224566

22 September 2017

Herpes simplex virus trans-regulatory protein ICP27 stabilizes and binds to 3' ends of labile mRNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=224566

22 September 2017

Detailed analysis of the portion of the herpes simplex virus type 1 genome encoding glycoprotein C

1 reference

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22 September 2017

Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter

1 reference

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22 September 2017

Cloning of herpes simplex virus type 1 sequences representing the whole genome

1 reference

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22 September 2017

Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene

1 reference

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22 September 2017

Transcriptional Regulation of Hemoglobin Switching in Chicken Embryos

1 reference

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22 September 2017

A new technique for the assay of infectivity of human adenovirus 5 DNA

1 reference

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22 September 2017

Activities of herpes simplex virus type 1 (HSV-1) ICP4 genes specifying nonsense peptides

1 reference

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22 September 2017

Regulation of the herpes simplex virus type 1 late (gamma 2) glycoprotein C gene: sequences between base pairs -34 to +29 control transient expression and responsiveness to transactivation by the products of the immediate early (alpha) 4 and 0 genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=224566

22 September 2017

Transcriptional control signals of a herpes simplex virus type 1 late (gamma 2) gene lie within bases -34 to +124 relative to the 5' terminus of the mRNA

1 reference

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22 September 2017

The control of herpes simplex virus type-1 late gene transcription: a 'TATA-box'/cap site region is sufficient for fully efficient regulated activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=224566

22 September 2017

Transcriptional control of herpesvirus gene expression: gene functions required for positive and negative regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=224566

22 September 2017

Herpes simplex virus type 1 ICP27 is an essential regulatory protein.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=224566

22 September 2017

Stimulation of expression of a herpes simplex virus DNA-binding protein by two viral functions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=224566

22 September 2017

gamma 2-Thymidine kinase chimeras are identically transcribed but regulated a gamma 2 genes in herpes simplex virus genomes and as beta genes in cell genomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=224566

22 September 2017

The herpes simplex virus type 1 alpha protein ICP27 can act as a trans-repressor or a trans-activator in combination with ICP4 and ICP0.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=224566

22 September 2017

Gene-specific transactivation by herpes simplex virus type 1 alpha protein ICP27.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=224566

22 September 2017

The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1.

1 reference

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22 September 2017

Herpes simplex virus type 1 ICP27 deletion mutants exhibit altered patterns of transcription and are DNA deficient

1 reference

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22 September 2017

Novel induction by herpes simplex virus of hybrid interferon gene transcripts driven by the strong cytomegalovirus IE94 promoter

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=224566

22 September 2017

The repressing and enhancing functions of the herpes simplex virus regulatory protein ICP27 map to C-terminal regions and are required to modulate viral gene expression very early in infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=224566

22 September 2017

Genetic evidence for two distinct transactivation functions of the herpes simplex virus alpha protein ICP27.

1 reference

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22 September 2017

Herpes simplex virus IE63 acts at the posttranscriptional level to stimulate viral mRNA 3' processing

1 reference

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22 September 2017

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters

1 reference

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22 September 2017

Herpes simplex virus infection selectively stimulates accumulation of beta interferon reporter gene mRNA by a posttranscriptional mechanism

1 reference

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22 September 2017

Temperature-sensitive mutants of herpes simplex virus type 1 defective in lysis but not in transformation

1 reference

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22 September 2017

Herpes simplex virus 1 ICP27 is required for transcription of two viral late (gamma 2) genes in infected cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=224566

25 September 2017

The herpes simplex virus immediate-early protein ICP27 shuttles between nucleus and cytoplasm

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=224566

25 September 2017

Activation of cellular promoters during herpes virus infection of biochemically transformed cells

1 reference

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25 September 2017

A herpes simplex virus type 1 function continuously required for early and late virus RNA synthesis

1 reference

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15 June 2018

The products of herpes simplex virus type 1 (HSV-1) immediate early genes 1, 2 and 3 can activate HSV-1 gene expression in trans

1 reference

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15 June 2018

Regulation of herpes simplex virus 1 genes: alpha gene sequence requirements for transient induction of indicator genes regulated by beta or late (gamma 2) promoters

1 reference

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15 June 2018

Alternative mechanisms for activation of human immunodeficiency virus enhancer in T cells

1 reference

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15 June 2018

Activation of herpes simplex virus 1 gamma 2 genes by viral DNA replication

1 reference

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15 June 2018

Transcriptional and post-transcriptional controls establish the cascade of herpes simplex virus protein synthesis

1 reference

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15 June 2018

Herpes simplex virus alpha protein ICP27 can inhibit or augment viral gene transactivation

1 reference

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The block to transcription elongation is promoter dependent in normal and Burkitt's lymphoma c-myc alleles

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15 June 2018

Promoter-independent activation of heterologous virus gene expression by the herpes simplex virus immediate-early protein ICP27.

1 reference

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15 June 2018

A herpesvirus regulatory protein appears to act post-transcriptionally by affecting mRNA processing

1 reference

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15 June 2018

Evidence that the herpes simplex virus immediate early protein ICP27 acts post-transcriptionally during infection to regulate gene expression

1 reference

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15 June 2018

Splicing inhibition at the level of spliceosome assembly in the presence of herpes simplex virus protein ICP27.

1 reference

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20 August 2018

Immediate early protein IE63 of herpes simplex virus type 1 binds RNA directly

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20 August 2018

The HSV-1 UL45 18 kDa gene product is a true late protein and a component of the virion.

1 reference

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New versatile plasmid vectors for expression of hybrid proteins coded by a cloned gene fused to lacZ gene sequences encoding an enzymatically active carboxy-terminal portion of beta-galactosidase

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20 August 2018

Identifiers

10.1128/JVI.77.18.9872-9884.2003

1 reference

Europe PubMed Central

PMC publication ID

16 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

16 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

16 September 2017

ResearchGate publication ID

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