Protein kinase C epsilon confers resistance of MCF-7 cells to TRAIL by Akt-dependent activation of Hdm2 and downregulation of p53. (Q40006116)

16 September 2017

title

Protein kinase C epsilon confers resistance of MCF-7 cells to TRAIL by Akt-dependent activation of Hdm2 and downregulation of p53. (English)

1 reference

16 September 2017

E Shankar

1

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16 September 2017

U Sivaprasad

series ordinal

2

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16 September 2017

A Basu

series ordinal

3

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16 September 2017

language of work or name

English

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publication date

3 March 2008

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16 September 2017

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16 September 2017

volume

27

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16 September 2017

issue

28

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16 September 2017

page(s)

3957-3966

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Mapping of the p53 and mdm-2 interaction domains

16 September 2017

cites work

1 reference

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Wild-type human p53 and a temperature-sensitive mutant induce Fas/APO-1 expression

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Regulation of caspase activation and cis-diamminedichloroplatinum(II)-induced cell death by protein kinase C

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Proteolytic activation of protein kinase C-epsilon by caspase-mediated processing and transduction of antiapoptotic signals

31 March 2020

1 reference

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Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

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Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

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Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

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Cytotoxic drug-induced, p53-mediated upregulation of caspase-8 in tumor cells

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Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane

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Stabilization of Mdm2 via decreased ubiquitination is mediated by protein kinase B/Akt-dependent phosphorylation

31 March 2020

1 reference

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Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death

31 March 2020

1 reference

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Mdm2 promotes the rapid degradation of p53

31 March 2020

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Targeting death receptors in cancer with Apo2L/TRAIL.

31 March 2020

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Regulation of p53 stability by Mdm2

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Selenium sensitizes MCF-7 breast cancer cells to doxorubicin-induced apoptosis through modulation of phospho-Akt and its downstream substrates

31 March 2020

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p53 upregulates death receptor 4 expression through an intronic p53 binding site

31 March 2020

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Protein kinase Cepsilon activates protein kinase B/Akt via DNA-PK to protect against tumor necrosis factor-alpha-induced cell death

31 March 2020

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A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

31 March 2020

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A novel form of Epstein-Barr virus latency in normal B cells in vivo

31 March 2020

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PUMA, a novel proapoptotic gene, is induced by p53

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Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

31 March 2020

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Akt enhances Mdm2-mediated ubiquitination and degradation of p53.

31 March 2020

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Regulation of the p53 tumor suppressor protein

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31 March 2020

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BID regulation by p53 contributes to chemosensitivity

31 March 2020

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p53 induces apoptosis by caspase activation through mitochondrial cytochrome c release.

31 March 2020

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Downregulation of Bid is associated with PKCepsilon-mediated TRAIL resistance

31 March 2020

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Regulating the p53 pathway: in vitro hypotheses, in vivo veritas

31 March 2020

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31 March 2020

Surfing the p53 network

1 reference

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Outcomes of p53 activation--spoilt for choice

31 March 2020

1 reference

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Live or let die: the cell's response to p53

31 March 2020

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TRAIL and apoptosis induction by TNF-family death receptors.

31 March 2020

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HDM2 phosphorylation by MAPKAP kinase 2.

31 March 2020

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KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene

31 March 2020

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PUMA induces the rapid apoptosis of colorectal cancer cells

31 March 2020

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Sequence-specific DNA binding by p53: identification of target sites and lack of binding to p53 - MDM2 complexes

31 March 2020

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HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/ONC.2008.39

1 reference

Dimensions Publication ID

16 September 2017

1049953305

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Fatcat ID

release_pnqi5fvdefbgvmkn7ppufnmqze

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/pnqi5fvdefbgvmkn7ppufnmqze

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference