Reduced glutathione biosynthesis in Drosophila melanogaster causes neuronal defects linked to copper deficiency (Q40018327)

16 September 2017

title

Reduced glutathione biosynthesis in Drosophila melanogaster causes neuronal defects linked to copper deficiency (English)

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Glutamate-cysteine ligase catalytic subunit Dmel_CG2259

16 September 2017

main subject

Drosophila melanogaster

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GOA release 2020-03-11

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Coral G Warr

3

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Sharon La Fontaine

object named as

Sharon La Fontaine

series ordinal

2

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Richard Burke

object named as

Richard Burke

series ordinal

4

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author name string

Stephen W Mercer

series ordinal

1

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16 September 2017

language of work or name

English

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publication date

6 February 2016

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Journal of Neurochemistry

16 September 2017

published in

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16 September 2017

volume

137

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16 September 2017

issue

3

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16 September 2017

page(s)

360-370

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16 September 2017

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Affinity gradients drive copper to cellular destinations

21 January 2018

1 reference

Alzheimer's disease and oxidative stress: implications for novel therapeutic approaches

21 January 2018

1 reference

Tissue-specific interplay between copper uptake and efflux in Drosophila.

21 January 2018

1 reference

Redox sulfur chemistry of the copper chaperone Atox1 is regulated by the enzyme glutaredoxin 1, the reduction potential of the glutathione couple GSSG/2GSH and the availability of Cu(I).

21 January 2018

1 reference

Mechanisms for activating Cu- and Zn-containing superoxide dismutase in the absence of the CCS Cu chaperone

21 January 2018

1 reference

Isolation of a candidate gene for Menkes disease that encodes a potential heavy metal binding protein

21 January 2018

1 reference

Copper at synapse: Release, binding and modulation of neurotransmission

21 January 2018

1 reference

A neuropeptide hormone cascade controls the precise onset of post-eclosion cuticular tanning in Drosophila melanogaster

21 January 2018

1 reference

Knockdown of glutamate-cysteine ligase by small hairpin RNA reveals that both catalytic and modulatory subunits are essential for the survival of primary neurons

21 January 2018

1 reference

ATP7A (Menkes protein) functions in axonal targeting and synaptogenesis

21 January 2018

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Copper(I) transfer into metallothionein mediated by glutathione

21 January 2018

1 reference

Intracellular copper transport in cultured hepatoma cells.

21 January 2018

1 reference

Antioxidant defence mechanisms: from the beginning to the end (of the beginning).

21 January 2018

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Functional partnership of the copper export machinery and glutathione balance in human cells

21 January 2018

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X-linked spinal muscular atrophy in mice caused by autonomous loss of ATP7A in the motor neuron

21 January 2018

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Copper overload and deficiency both adversely affect the central nervous system of Drosophila

21 January 2018

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Glutathione deficiency leads to mitochondrial damage in brain

21 January 2018

1 reference

PHM is required for normal developmental transitions and for biosynthesis of secretory peptides in Drosophila

21 January 2018

1 reference

21 January 2018

1 reference

The copper-enzyme family of dopamine beta-monooxygenase and peptidylglycine alpha-hydroxylating monooxygenase: resolving the chemical pathway for substrate hydroxylation

21 January 2018

1 reference

Inherited copper transport disorders: biochemical mechanisms, diagnosis, and treatment

21 January 2018

1 reference

NMDA receptor channels: subunit-specific potentiation by reducing agents

21 January 2018

1 reference

Glutaredoxins in thiol/disulfide exchange.

21 January 2018

1 reference

Copper-dependent interaction of glutaredoxin with the N termini of the copper-ATPases (ATP7A and ATP7B) defective in Menkes and Wilson diseases

21 January 2018

1 reference

Brain metal accumulation in Wilson's disease.

21 January 2018

1 reference

Age-associated decline in gamma-glutamylcysteine synthetase gene expression in rats.

21 January 2018

1 reference

Copper, iron and zinc in Alzheimer's disease senile plaques

21 January 2018

1 reference

Functional dissection of a neuronal network required for cuticle tanning and wing expansion in Drosophila

21 January 2018

1 reference

Detection of genetically altered copper levels in Drosophila tissues by synchrotron x-ray fluorescence microscopy

21 January 2018

1 reference

Cellular glutathione plays a key role in copper uptake mediated by human copper transporter 1.

21 January 2018

1 reference

Isolation of a partial candidate gene for Menkes disease by positional cloning

21 January 2018

1 reference

Posttranslational modification of cysteine in redox signaling and oxidative stress: Focus on s-glutathionylation

21 January 2018

1 reference

Essential roles in development and pigmentation for the Drosophila copper transporter DmATP7.

21 January 2018

1 reference

Overexpression of glutamate-cysteine ligase extends life span in Drosophila melanogaster

21 January 2018

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Involvement of redox state in the aging of Drosophila melanogaster

21 January 2018

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Targeted ablation of CCAP neuropeptide-containing neurons of Drosophila causes specific defects in execution and circadian timing of ecdysis behavior.

21 January 2018

1 reference

Toxicity of cysteine and cysteine sulphinic acid to human neuronal cell-lines.

21 January 2018

1 reference

Bursicon functions within the Drosophila CNS to modulate wing expansion behavior, hormone secretion, and cell death

21 January 2018

1 reference

γ-Glutamylcysteine detoxifies reactive oxygen species by acting as glutathione peroxidase-1 cofactor

21 January 2018

1 reference

Appraising the brain's energy budget

21 January 2018

1 reference

FlyBase: introduction of the Drosophila melanogaster Release 6 reference genome assembly and large-scale migration of genome annotations

21 January 2018

1 reference

NMDA receptor activation mediates copper homeostasis in hippocampal neurons

21 January 2018

1 reference

Role of the Menkes copper-transporting ATPase in NMDA receptor-mediated neuronal toxicity

21 January 2018

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Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia

21 January 2018

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Role of reactive oxygen species in biological processes

21 January 2018

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Role of glutaredoxin1 and glutathione in regulating the activity of the copper-transporting P-type ATPases, ATP7A and ATP7B.

21 January 2018

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Reduced and oxidized glutathione in the substantia nigra of patients with Parkinson's disease

21 January 2018

1 reference

Identification of two cysteine residues that are required for redox modulation of the NMDA subtype of glutamate receptor

21 January 2018

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Drosophila Ctr1A functions as a copper transporter essential for development

21 January 2018

1 reference

Isolation of a candidate gene for Menkes disease and evidence that it encodes a copper-transporting ATPase

21 January 2018

1 reference

Diminishing glutathione availability and age-associated decline in neuronal excitability

21 January 2018

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Neurotoxicity from glutathione depletion is dependent on extracellular trace copper

21 January 2018

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The reaction of superoxide with reduced glutathione.

21 January 2018

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Unification of the copper(I) binding affinities of the metallo-chaperones Atx1, Atox1, and related proteins: detection probes and affinity standards.

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1111/JNC.13567

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16 September 2017

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