Selection against the dihydrofolate reductase-thymidylate synthase (DHFR-TS) locus as a probe of genetic alterations in Leishmania major. (Q40020029)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8816478%20AND%20SRC:MED&resulttype=core&format=json

19 October 2019

title

Selection against the dihydrofolate reductase-thymidylate synthase (DHFR-TS) locus as a probe of genetic alterations in Leishmania major (English)

1 reference

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19 October 2019

Leishmania major

1 reference

inferred from title

author

Frederico Gueiros Filho

series ordinal

1

1 reference

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19 October 2019

author name string

S M Beverley

series ordinal

2

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19 October 2019

language of work or name

English

0 references

publication date

1 October 1996

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Molecular and Cellular Biology

19 October 2019

published in

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19 October 2019

volume

16

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19 October 2019

issue

10

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19 October 2019

page(s)

5655-5663

1 reference

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IMPROVED METHOD FOR THE ISOLATION OF THYMINE-REQUIRING MUTANTS OF ESCHERICHIA COLI

19 October 2019

cites work

1 reference

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22 September 2017

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22 September 2017

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22 September 2017

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PTR1: a reductase mediating salvage of oxidized pteridines and methotrexate resistance in the protozoan parasite Leishmania major.

22 September 2017

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22 September 2017

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22 September 2017

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22 September 2017

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Overproduction of a bifunctional thymidylate synthetase-dihydrofolate reductase and DNA amplification in methotrexate-resistant Leishmania tropica

22 September 2017

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A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

22 September 2017

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22 September 2017

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The genetics of medically important fungi

22 September 2017

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Primary structure of the gene encoding the bifunctional dihydrofolate reductase-thymidylate synthase of Leishmania major

22 September 2017

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A clonal theory of parasitic protozoa: the population structures of Entamoeba, Giardia, Leishmania, Naegleria, Plasmodium, Trichomonas, and Trypanosoma and their medical and taxonomical consequences

22 September 2017

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Stable transfection of the human parasite Leishmania major delineates a 30-kilobase region sufficient for extrachromosomal replication and expression

22 September 2017

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Drug resistance and P-glycoprotein gene amplification in the protozoan parasite Leishmania

22 September 2017

1 reference

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Gene amplification in Leishmania

22 September 2017

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Double targeted gene replacement for creating null mutants

22 September 2017

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Production of homozygous mutant ES cells with a single targeting construct

22 September 2017

1 reference

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Molecular karyotype analysis in Leishmania.

22 September 2017

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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

22 September 2017

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On the nature of hereditable variation in cultured somatic cells

22 September 2017

1 reference

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New mechanisms of drug resistance in parasitic protozoa

22 September 2017

1 reference

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A test for genetic exchange in mixed infections of Leishmania major in the sand fly Phlebotomus papatasi

25 September 2017

1 reference

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Isolation and characterization of a mutant dihydrofolate reductase-thymidylate synthase from methotrexate-resistant Leishmania cells.

25 September 2017

1 reference

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Cloning and sequencing of the Leishmania major actin-encoding gene.

17 June 2018

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Selection of mammalian thymidine auxotrophic cell mutants defective in thymidylate synthase by their reduced sensitivity to methotrexate

17 June 2018

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Reductions in methotrexate and folate influx in methotrexate-resistant lines of Leishmania major are independent of R or H region amplification.

17 June 2018

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A ricin agglutinin-resistant clone of Leishmania donovani deficient in lipophosphoglycan.

17 June 2018

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Methotrexate-resistant Leishmania donovani genetically deficient in the folate-methotrexate transporter

17 June 2018

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Biochemistry and regulation of folate and methotrexate transport in Leishmania major

17 June 2018

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Multiple drug resistance and conservative amplification of the H region in Leishmania major

17 June 2018

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Lipophosphoglycan expression and virulence in ricin-resistant variants of Leishmania major

17 June 2018

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Consecutive inactivation of both alleles of the pim-1 proto-oncogene by homologous recombination in embryonic stem cells

17 June 2018

1 reference

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Rate and mechanism of generation of beta 2-microglobulin mutants from a heterozygous murine cell line

17 June 2018

1 reference

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Repeated use of GAL1 for gene disruption in Candida albicans

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231565

A DNA sequence (LD1) which occurs in several genomic organizations in Leishmania

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231565

A member of the aldoketo reductase family confers methotrexate resistance in Leishmania

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231565

Purification and characterization of the bifunctional thymidylate synthetase-dihydrofolate reductase from methotrexate-resistant Leishmania tropica.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231565

Recurrent polymorphisms in small chromosomes of Leishmania tarentolae after nutrient stress or subcloning

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231565

The origin of the bifunctional dihydrofolate reductase-thymidylate synthase isogenes of Arabidopsis thaliana.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231565

Rapid isolation of DNA from trypanosomatid protozoa using a simple 'mini-prep' procedure.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231565

Diploid yeast cells yield homozygous spontaneous mutations.

20 August 2018

1 reference

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On the introduction of genetically modified Leishmania outside the laboratory.

20 August 2018

1 reference

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Changes in folate and pterin metabolism after disruption of the Leishmania H locus short chain dehydrogenase gene.

20 August 2018

1 reference

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Structure of and kinetic channelling in bifunctional dihydrofolate reductase-thymidylate synthase

20 August 2018

1 reference

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A specialized pathway affecting virulence glycoconjugates of Leishmania.

20 August 2018

1 reference

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Genetic demonstration of mitotic recombination in cultured Chinese hamster cell hybrids.

20 August 2018

1 reference

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Saturation site-directed mutagenesis of thymidylate synthase.

20 August 2018

1 reference

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Isolation and characterization of mutants of Saccharomyces cerevisiae auxotrophic and conditionally auxotrophic for 5'-dTMP

20 August 2018

1 reference

12 December 2020

A rapid radiometric assay for dihydrofolate reductase

1 reference

12 December 2020

Genetic analysis of adenine metabolism in Leishmania donovani promastigotes. Evidence for diploidy at the adenine phosphoribosyltransferase locus

1 reference

12 December 2020

Variants with reduced virulence derived from Leishmania major after mutagen treatment

1 reference

12 December 2020

Gene replacement in parasitic protozoa

1 reference

12 December 2020

Introduction of a subtle mutation into the Hox-2.6 locus in embryonic stem cells

1 reference

12 December 2020

Thymidine kinase as a negative selectable marker in Leishmania major

1 reference

12 December 2020

Altering mice by homologous recombination using embryonic stem cells

1 reference

12 December 2020

An Isotopic Assay for Thymidylate Synthetase*

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12 December 2020

Identifiers

DOI

10.1128/MCB.16.10.5655

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8816478%20AND%20SRC:MED&resulttype=core&format=json

19 October 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8816478%20AND%20SRC:MED&resulttype=core&format=json

19 October 2019

1 reference