UV-mediated regulation of the anti-senescence factor Tbx2. (Q40048508)

16 September 2017

title

UV-mediated regulation of the anti-senescence factor Tbx2. (English)

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16 September 2017

5

Sharon Prince

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Colin R. Goding

object named as

Colin R Goding

4

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author name string

Amaal Abrahams

1

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16 September 2017

Shaheen Mowla

2

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16 September 2017

M Iqbal Parker

3

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16 September 2017

Sharon Prince

5

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16 September 2017

language of work or name

English

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publication date

19 November 2007

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Journal of Biological Chemistry

16 September 2017

published in

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16 September 2017

volume

283

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16 September 2017

issue

4

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16 September 2017

page(s)

2223-2230

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An ancient family of embryonically expressed mouse genes sharing a conserved protein motif with the T locus

16 September 2017

cites work

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A dominant repression domain in Tbx3 mediates transcriptional repression and cell immortalization: relevance to mutations in Tbx3 that cause ulnar-mammary syndrome

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Differential DNA binding and transcription modulation by three T-box proteins, T, TBX1 and TBX2

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Senescence bypass screen identifies TBX2, which represses Cdkn2a (p19(ARF)) and is amplified in a subset of human breast cancers.

21 January 2018

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TBX-3, the gene mutated in Ulnar-Mammary Syndrome, is a negative regulator of p19ARF and inhibits senescence

21 January 2018

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The T-box repressors TBX2 and TBX3 specifically regulate the tumor suppressor gene p14ARF via a variant T-site in the initiator

21 January 2018

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Tbx2 directly represses the expression of the p21(WAF1) cyclin-dependent kinase inhibitor

21 January 2018

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Tbx2 is overexpressed and plays an important role in maintaining proliferation and suppression of senescence in melanomas

21 January 2018

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TBX3 and its isoform TBX3+2a are functionally distinctive in inhibition of senescence and are overexpressed in a subset of breast cancer cell lines

21 January 2018

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Met proto-oncogene and insulin-like growth factor binding protein 3 overexpression correlates with metastatic ability in well-differentiated pancreatic endocrine neoplasms

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Tbx3 expression is related to apoptosis and cell proliferation in rat bladder both hyperplastic epithelial cells and carcinoma cells

21 January 2018

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Tbx3 is a downstream target of the Wnt/beta-catenin pathway and a critical mediator of beta-catenin survival functions in liver cancer.

21 January 2018

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Increased expression of cSHMT, Tbx3 and utrophin in plasma of ovarian and breast cancer patients

21 January 2018

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Tbx3 impinges on the p53 pathway to suppress apoptosis, facilitate cell transformation and block myogenic differentiation

21 January 2018

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21 January 2018

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21 January 2018

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Mitogen-activated protein kinase p38 defines the common senescence-signalling pathway

21 January 2018

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Sequential activation of the MEK-extracellular signal-regulated kinase and MKK3/6-p38 mitogen-activated protein kinase pathways mediates oncogenic ras-induced premature senescence

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The stress-activated protein kinases p38 alpha and JNK1 stabilize p21(Cip1) by phosphorylation

21 January 2018

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The C-terminal domain of p21 inhibits nucleotide excision repair In vitro and In vivo

21 January 2018

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UV irradiation triggers ubiquitin-dependent degradation of p21(WAF1) to promote DNA repair

21 January 2018

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Ultraviolet radiation down-regulates expression of the cell-cycle inhibitor p21WAF1/CIP1 in human cancer cells independently of p53.

21 January 2018

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21 January 2018

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21 January 2018

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Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation

21 January 2018

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The Usf-1 transcription factor is a novel target for the stress-responsive p38 kinase and mediates UV-induced Tyrosinase expression.

21 January 2018

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The gene encoding the T-box factor Tbx2 is a target for the microphthalmia-associated transcription factor in melanocytes

21 January 2018

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TBX2/TBX3 transcriptional factor homologue controls olfactory adaptation in Caenorhabditis elegans

21 January 2018

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Identification of a novel nuclear localization signal in Tbx1 that is deleted in DiGeorge syndrome patients harboring the 1223delC mutation

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1074/JBC.M705651200

1 reference

16 September 2017

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